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The 15kDa Selenoprotein and Thioredoxin Reductase 1 Promote Colon Cancer by Different Pathways
(Public Library of Science, 2015)Selenoproteins mediate much of the cancer-preventive properties of the essential nutrient selenium, but some of these proteins have been shown to also have cancer-promoting effects. We examined the contributions of the ... -
1695-1995: Some tercentenary thoughts on the freedoms of the press
(Harvard Library, 1997) -
The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity
(Nature Publishing Group, 2015)Anatomical structures and mechanisms linking genes to neuropsychiatric disorders are not deciphered. Reciprocal copy number variants at the 16p11.2 BP4-BP5 locus offer a unique opportunity to study the intermediate phenotypes ... -
16S rRNA Phylogenetic Investigation of the Candidate Division "Korarchaeota"
(American Society for Microbiology, 2006)The environmental distribution and phylogeny of “Korarchaeota,” a proposed ancient archaeal division, was investigated by using the 16S rRNA gene framework. Korarchaeota-specific primers were designed based on previously ... -
17-beta-Estradiol in relation to age at menarche and adult obesity in premenopausal women
(Oxford University Press, 2007)BACKGROUND: We hypothesize that premenopausal endogenous estradiol may be associated with age at menarche and adult overweight and obesity, potentially contributing to breast cancer risk. METHODS: We assessed age at menarche ... -
17β-Estradiol Levels During An Entire Menstrual Cycle In Response To Adult Stature and Insulin, Of Possible Importance For Breast Cancer Risk: The EBBA-I study.
(American Association for Cancer Research, 2009)Background: The normal breast cells develop into malignant cells as a result of a complex interplay between genetic, environmental, nutritional and hormonal factors. Attained adult stature and insulin levels, risk factors ... -
18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Management of Aggressive Non-Hodgkin's B-Cell Lymphoma
(International Scholarly Research Network, 2012)18-Fluorodeoxyglucose (FDG-PET/CT) is an established imaging modality that has been proven to be of benefit in the management of aggressive B-cell non-Hodgkin's lymphoma, such as diffuse large B-cell lymphoma and advanced ... -
18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload–induced maladaptive cardiac remodeling
(The Rockefeller University Press, 2014)N-3 polyunsaturated fatty acids (PUFAs) have potential cardiovascular benefit, although the mechanisms underlying this effect remain poorly understood. Fat-1 transgenic mice expressing Caenorhabditis elegans n-3 fatty acid ... -
The 1824 Confederation of the Equator and Cultural Production in Brazil
(2015-05-17)During the 1824 Confederation of the Equator revolt in northeastern Brazil, a middle-class junta rose to power and waged a war against the monarchy in Rio, journalists participating in creating pedagogical ideological ... -
The 1850 Harvard Medical School dispute and the admission of African American students
(Harvard Library, 1992) -
[18F]-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography of LAPC4-CR Castration-Resistant Prostate Cancer Xenograft Model in Soft Tissue Compartments1
(Neoplasia Press, 2015)Preclinical xenograft models have contributed to advancing our understanding of the molecular basis of prostate cancer and to the development of targeted therapy. However, traditional preclinical in vivo techniques using ... -
18q Loss of Heterozygosity in Microsatellite Stable Colorectal Cancer is Correlated with CpG Island Methylator Phenotype-negative (CIMP-0) and Inversely with CIMP-low and CIMP-high
(BioMed Central, 2007)Background: The CpG island methylator phenotype (CIMP) with widespread promoter methylation is a distinct epigenetic phenotype in colorectal cancer, associated with microsatellite instability-high (MSI-high) and BRAF ... -
A 19-year-old at 37 weeks gestation with an acute acetylsalicylic acid overdose
(Oxford University Press, 2011)Acute salicylate overdose in pregnancy is potentially fatal for both the mother and fetus and presents a unique challenge in intensive care management. While suggested thresholds exist for hemodialysis in adults with toxic ... -
The 2-oxoglutarate analog 3-oxoglutarate decreases normoxic hypoxia-inducible factor-1α in cancer cells, induces cell death, and reduces tumor xenograft growth
(Dove Medical Press, 2016)The cellular response to hypoxia is primarily regulated by the hypoxia-inducible factors (HIFs). HIF-1α is also a major mediator of tumor physiology, and its abundance is correlated with therapeutic resistance in a broad ... -
2-Selmer groups and Heegner points on elliptic curves
(2015-05-07)This thesis studies several aspects of the arithmetic of elliptic curves. In particular, we explore the prediction of the Birch and Swinnerton-Dyer conjecture when the 2-Selmer group has rank one. For certain elliptic ... -
2-Year BMI Changes of Children Referred for Multidisciplinary Weight Management
(Hindawi Publishing Corporation, 2014)Objective. To examine body mass index (BMI) changes among pediatric multidisciplinary weight management participants and nonparticipants. Design. In this retrospective database analysis, we used multivariable mixed effect ... -
The 2.1-D Sketch
(IEEE Computer Society Press, 1990)A model is described for image segmentation that tries to capture the low-level depth reconstruction exhibited in early human vision, giving an important role to edge terminations. The problem is to find a decomposition ... -
20-HETE Mediates Ozone-Induced, Neutrophil-Independent Airway Hyper-Responsiveness in Mice
(Public Library of Science, 2010)Background Ozone, a pollutant known to induce airway hyper-responsiveness (AHR), increases morbidity and mortality in patients with obstructive airway diseases and asthma. We postulate oxidized lipids mediate in vivo ... -
A >200 meV Uphill Thermodynamic Landscape for Radical Transport in Escherichia coli Ribonucleotide Reductase Determined Using Fluorotyrosine-Substituted Enzymes
(American Chemical Society, 2016)Escherichia coli class Ia ribonucleotide reductase (RNR) converts ribonucleotides to deoxynucleotides. A diferric-tyrosyl radical (Y122•) in one subunit (β2) generates a transient thiyl radical in another subunit (α2) via ...