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Now showing items 21101-21120 of 58461
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Functional regulation of an arenavirus polymerase complex
(2021-07-12)Emerging RNA viruses present recurring challenges to human, livestock, and plant healthcare efforts worldwide. With compact genomes copied by an inherently error-prone RNA-dependent RNA polymerase (RdRP), RNA viruses are ... -
Functional Relationship between Merlin and the ERM Proteins
(2012-11-15)The ability to spatially restrict specific activities across the cell cortex functionally defines individual cells and tissues. This is achieved, in part, via the assembly of protein complexes that link the plasma membrane ... -
Functional RNA Interference (RNAi) Screen Identifies System a Neutral Amino Acid Transporter 2 (SNAT2) as a Mediator of Arsenic-induced Endoplasmic Reticulum Stress
(American Society for Biochemistry and Molecular Biology, 2012)Exposure to the toxic metalloid arsenic is associated with diabetes and cancer and causes proteotoxicity and endoplasmic reticulum (ER) stress at the cellular level. Adaptive responses to ER stress are implicated in cancer ... -
Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration
(Public Library of Science, 2015)ERp57 (also known as grp58 and PDIA3) is a protein disulfide isomerase that catalyzes disulfide bonds formation of glycoproteins as part of the calnexin and calreticulin cycle. ERp57 is markedly upregulated in most common ... -
Functional role of the soluble guanylyl cyclase α1 subunit in vascular smooth muscle relaxation
(Oxford University Press (OUP), 2007)Objective: Soluble guanylyl cyclase (sGC), the predominant receptor for nitric oxide (NO), exists in 2 active isoforms (α2β1 and α1β1). In vascular tissue sGCα1β1 is believed to be the most important. The aim of our study ... -
Functional Roles of 10 Hz Alpha-Band Power Modulating Engagement and Disengagement of Cortical Networks in a Complex Visual Motion Task
(Public Library of Science, 2014)Alpha band power, particularly at the 10 Hz frequency, is significantly involved in sensory inhibition, attention modulation, and working memory. However, the interactions between cortical areas and their relationship to ... -
Functional screening identifies miR-315 as a potent activator of Wingless signaling
(Proceedings of the National Academy of Sciences, 2007-11-07)The existence of vast regulatory networks mediated by microRNAs (miRNAs) suggests broad potential for miRNA dysfunction to contrib- ute to disease. However, relatively few miRNA–target interactions are likely to make ... -
Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms
(Oxford University Press, 2014)Using a Drosophila model of Alzheimers disease (AD), we systematically evaluated 67 candidate genes based on AD-associated genomic loci (P 10(4)) from published human genome-wide association studies (GWAS). Genetic ... -
A Functional Selection Model Explains Evolutionary Robustness Despite Plasticity in Regulatory Networks
(Nature Publishing Group, 2012)Evolutionary rewiring of regulatory networks is an important source of diversity among species. Previous evidence suggested substantial divergence of regulatory networks across species. However, systematically assessing ... -
Functional SNPs in HSPA1A Gene Predict Risk of Coronary Heart Disease
(Public Library of Science, 2009)Background: HSP70 plays crucial roles in endothelial cell apoptosis, which is involved in the early phase and progress of coronary heart disease (CHD). However, the association between polymorphisms of HSP70 genes and the ... -
Functional specializations in Drosophila primary mechanosensory neurons: experimental methods, physiology, and models
(2021-11-16)Primary mechanosensors encode the detailed features of mechanical stimuli, with different neurons extracting different stimulus features. How this occurs is not fully understood. This is due partially to the difficulty of ... -
Functional Status Predicts Acute Care Readmissions from Inpatient Rehabilitation in the Stroke Population
(Public Library of Science, 2015)Objective: Acute care readmission risk is an increasingly recognized problem that has garnered significant attention, yet the reasons for acute care readmission in the inpatient rehabilitation population are complex and ... -
Functional Studies of Candidate Oncogenes in Non-Small Cell Lung Cancer
(2013-10-17)Cancer is a set of complex genetic diseases driven by diverse genomic alterations. The genomic study of cancer has enabled the discovery of novel, targetable events in almost all cancer types and in turn, has led to the ... -
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
(National Academy of Sciences, 2002)Mammalian polo-like kinase (Pik) acts at various stages in early and late mitosis. Pik is phosphorylated and activated in mitosis, and the proper subcellular localization of Pik is essential for mitotic regulation. We have ... -
Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing
(Public Library of Science, 2016)Genetic testing in the clinic and research lab is becoming more routinely used to identify rare genetic variants. However, attributing these rare variants as the cause of disease in an individual patient remains challenging. ... -
Functional Vascular Endothelium Derived from Human Induced Pluripotent Stem Cells
(Elsevier, 2013)Summary Vascular endothelium is a dynamic cellular interface that displays a unique phenotypic plasticity. This plasticity is critical for vascular function and when dysregulated is pathogenic in several diseases. Human ... -
Functional, Developmental and Morphological Integration: The Case of the Head and Forelimb in Bipedal Hominins
(John Wiley & Sons, 2008)Integration, a fundamental property of organisms, occurs via multiple mechanisms and for diverse reasons. Although there has been substantial work on the genetic and epigenetic mechanisms by which developmental integration ... -
Functionality through multistability: from deployable structures to soft robots
(2021-12-14)Inflating a rubber balloon leads to a dramatic shape change: a property that is exploited in the design of deployable structures and soft robots. On the one hand, inflation can be used to transform seemingly flat shapes ... -
Functionalizing Aromatic Compounds with Optical Cycling Centers
(Nature, 2022-07-25) -
Functionally distinct patterns of nucleosome remodeling at enhancers in glucocorticoid-treated acute lymphoblastic leukemia
(BioMed Central, 2015)Background: Precise nucleosome positioning is an increasingly recognized feature of promoters and enhancers, reflecting complex contributions of DNA sequence, nucleosome positioning, histone modification and transcription ...