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Now showing items 24535-24554 of 56863
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Identification of novel myeloma-specific XBP1 peptides able to generate cytotoxic T lymphocytes: A potential therapeutic application in multiple myeloma
(2012)The purpose of these studies was to identify HLA-A2+ immunogenic peptides derived from XBP1 antigens to induce a multiple myeloma (MM)-specific immune response. Six native peptides from non-spliced XBP1 antigen and three ... -
Identification of Novel Non-Coding Small RNAs from Streptococcus Pneumoniae TIGR4 Using High-Resolution Genome Tiling Arrays
(BioMed Central, 2010)Background: The identification of non-coding transcripts in human, mouse, and Escherichia coli has revealed their widespread occurrence and functional importance in both eukaryotic and prokaryotic life. In prokaryotes, ... -
Identification of Novel Pro-Migratory, Cancer-Associated Genes Using Quantitative, Microscopy-Based Screening
(Public Library of Science, 2008)Background: Cell migration is a highly complex process, regulated by multiple genes, signaling pathways and external stimuli. To discover genes or pharmacological agents that can modulate the migratory activity of cells, ... -
Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase
(Public Library of Science, 2015)Oncogenic mutation of the RET receptor tyrosine kinase is observed in several human malignancies. Here, we describe three novel type II RET tyrosine kinase inhibitors (TKI), ALW-II-41-27, XMD15-44 and HG-6-63-01, that ... -
Identification of Novel sRNAs in Mycobacterial Species
(Public Library of Science, 2013)Bacterial small RNAs (sRNAs) are short transcripts that typically do not encode proteins and often act as regulators of gene expression through a variety of mechanisms. Regulatory sRNAs have been identified in many species, ... -
Identification of Novel Type 2 Diabetes Candidate Genes Involved in the Crosstalk between the Mitochondrial and the Insulin Signaling Systems
(Public Library of Science, 2012)Type 2 Diabetes (T2D) is a highly prevalent chronic metabolic disease with strong co-morbidity with obesity and cardiovascular diseases. There is growing evidence supporting the notion that a crosstalk between mitochondria ... -
Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis
(2014)Summary Insulin resistance is a sine qua non of Type 2 diabetes (T2D) and a frequent complication of multiple clinical conditions, including obesity, aging, and steroid use, among others. How such a panoply of insults can ... -
Identification of Orch3, a Locus Controlling Dominant Resistance to Autoimmune Orchitis, as Kinesin Family Member 1C
(Public Library of Science, 2012)Experimental autoimmune orchitis (EAO), the principal model of non-infectious testicular inflammatory disease, can be induced in susceptible mouse strains by immunization with autologous testicular homogenate and appropriate ... -
Identification of Panel Data Models with Endogenous Censoring
(2015)We study inference on parameters in censored panel data models, where the censoring can depend on both observable and unobservable variables in arbitrary ways. Under some general conditions, we characterize the information ... -
Identification of pathogen genomic variants through an integrated pipeline
(BioMed Central, 2014)Background: Whole-genome sequencing represents a powerful experimental tool for pathogen research. We present methods for the analysis of small eukaryotic genomes, including a streamlined system (called Platypus) for finding ... -
Identification of Phthalates in Medications and Dietary Supplement Formulations in the United States and Canada
(National Institute of Environmental Health Sciences, 2011)Background: In animal studies, some :ortho-phthalates, including di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP), have been shown to be reproductive and developmental toxicants. Human studies show widespread ... -
Identification of pneumococcal colonization determinants in the stringent response pathway facilitated by genomic diversity
(BioMed Central, 2015)Background: Understanding genetic determinants of a microbial phenotype generally involves creating and comparing isogenic strains differing at the locus of interest, but the naturally existing genomic and phenotypic ... -
Identification of Podocalyxin as a Candidate Gene in Focal Segmental Glomerulosclerosis
(2015-06-08)Studies of rare monogenetic forms of the glomerular kidney disease focal segmental glomerulosclerosis (FSGS) have highlighted the importance of the podocyte in glomerular filtration. Recent reports have also demonstrated ... -
Identification of Potent Ebola Virus Entry Inhibitors with Suitable Properties for in Vivo Studies
(American Chemical Society (ACS), 2018-06-19)Previous studies identified an adamantane dipeptide piperazine 3.47 that inhibits Ebola virus (EBOV) infection by targeting the essential receptor Niemann–Pick C1 (NPC1). The physicochemical properties of 3.47 limit its ... -
Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
(American Association for the Advancement of Science, 2015)The tuberous sclerosis complex (TSC) family of tumor suppressors, TSC1 and TSC2, function together in an evolutionarily conserved protein complex that is a point of convergence for major cell signaling pathways that regulate ... -
Identification of Preferences in Network Formation Games
(2015)This paper provides a framework for identifying preferences in a large network under the assumption of pairwise stability of network links. Network data present difficulties for identification, especially when links between ... -
Identification of priorities for improvement of medication safety in primary care: a PRIORITIZE study
(BioMed Central, 2016)Background: Medication error is a frequent, harmful and costly patient safety incident. Research to date has mostly focused on medication errors in hospitals. In this study, we aimed to identify the main causes of, and ... -
The Identification of Prognostic Factors and Survival Statistics of Conventional Central Chondrosarcoma
(Hindawi Publishing Corporation, 2015)Introduction:. Chondrosarcomas are malignant bone tumors that are characterized by the production of chondroid tissue. Since radiation therapy and chemotherapy have limited effect on chondrosarcoma, treatment of most ... -
Identification of Protective Pneumococcal \(T_{H}17\) Antigens from the Soluble Fraction of a Killed Whole Cell Vaccine
(Public Library of Science, 2012)Mucosal or parenteral immunization with a killed unencapsulated pneumococcal whole cell antigen (WCA) with an adjuvant protects mice from colonization by a \(T_{H}17\) CD4+ cell-mediated mechanism. Using preparative SDS ...