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Now showing items 27582-27601 of 56286
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Isoflurane-Induced Apoptosis: A Potential Pathogenic Link Between Delirium and Dementia
(Oxford University Press (OUP), 2006)Background. Dementia and delirium have been postulated to share common pathophysiologic mechanisms; however, identification of these unifying mechanisms has remained elusive. The inhalation anesthetic isoflurane has been ... -
Isogenic Human Pluripotent Stem Cell Models of Cardiovascular Disease-Associated Genetic Variation
(2016-03-30)A complex interplay of genetic and environmental factors underlies the development of common human diseases such as cardiovascular disease. Despite widespread use of existing medications, coronary heart disease (CHD), ... -
Isolated branches in the phylogeny of Platyhelminthes
(2015-03-06)This dissertation examines the early phylogenetic divergences of the phylum Platyhelminthes using molecular sequence data, with an emphasis on the placement and evolutionary significance of several enigmatic and largely ... -
Isolated Capital Cities, Accountability and Corruption: Evidence from US States
(American Economic Association, 2014)We show that isolated capital cities are robustly associated with greater levels of corruption across US states, in line with the view that this isolation reduces accountability. We then provide direct evidence that the ... -
Isolated cell behavior drives the evolution of antibiotic resistance
(John Wiley & Sons, Ltd, 2015)Bacterial antibiotic resistance is typically quantified by the minimum inhibitory concentration (MIC), which is defined as the minimal concentration of antibiotic that inhibits bacterial growth starting from a standard ... -
Isolating Live Cells After High-Throughput, Long-Term, Time-Lapse Microscopy
(Springer Science and Business Media LLC, 2019-11-25)Single-cell genetic screens can be incredibly powerful, but current high-throughput platforms do not track dynamics, and even for non-dynamic properties they struggle to separate mutants of interest from phenotypic outliers ... -
Isolating Spatial Autocorrelation, Aggregation Bias, and Distributional Violations in Ecological Inference: Comment on Anselin and Cho
(Oxford University Press, 2002) -
Isolation and Analysis of Rare Norovirus Recombinants from Coinfected Mice Using Drop-Based Microfluidics
(American Society for Microbiology, 2015)Human noroviruses (HuNoVs) are positive-sense RNA viruses that can cause severe, highly infectious gastroenteritis. HuNoV outbreaks are frequently associated with recombination between circulating strains. Strain genotyping ... -
Isolation and Characterization of Distal Lung Progenitor Cells
(Humana Press, 2012-04-14)The majority of epithelial cells in the distal lung of rodents and humans are quiescent in vivo, yet certain cell populations retain an intrinsic capacity to proliferate and differentiate in response to lung injury or in ... -
Isolation and characterization of novel RECK tumor suppressor gene splice variants
(Impact Journals LLC, 2015)Glioblastoma multiforme is the most common and lethal of the central nervous system glial-derived tumors. RECK suppresses tumor invasion by negatively regulating at least three members of the matrix metalloproteinase family: ... -
Isolation and co-culture of rat parenchymal and non-parenchymal liver cells to evaluate cellular interactions and response
(Nature Publishing Group, 2016)The liver is a central organ in the human body, and first line of defense between host and external environment. Liver response to any external perturbation is a collective reaction of resident liver cells. Most of the ... -
Isolation and Culture of Post-Natal Mouse Cerebellar Granule Neuron Progenitor Cells and Neurons
(Journal of Visualized Experiments, 2009)The cerebellar cortex is a well described structure that provides unique opportunities for studying neuronal properties and development. Of the cerebellar neuronal types (granule cells, Purkinje cells and inhibitory ... -
Isolation and Economic Life in Eighteenth-Century France
(Oxford University Press (OUP), 2014) -
Isolation and Synthesis of a Bacterially Produced Inhibitor of Rosette Development in Choanoflagellates
(American Chemical Society, 2016)The choanoflagellate Salpingoeca rosetta is a microbial marine eukaryote that can switch between unicellular and multicellular states. As one of the closest living relatives of animals, this organism has become a model for ... -
Isolation of a novel basic FGF-binding peptide with potent antiangiogenetic activity
(Blackwell Publishing Ltd, 2008)Abstract Basic fibroblast growth factor (bFGF), which plays an important role in tumour angiogenesis and progression, provides a potential target for cancer therapy. Here we screened a phage display heptapeptide library ... -
Isolation of Monoclonal Antibodies with Predetermined Conformational Epitope Specificity
(Public Library of Science, 2012)Existing technologies allow isolating antigen-specific monoclonal antibodies (mAbs) from B cells. We devised a direct approach to isolate mAbs with predetermined conformational epitope specificity, using epitope mimetics ... -
Isolation of peptide aptamers that inhibit intracellular processes
(National Academy of Sciences, 2000) -
Isolation of Progenitors that Exhibit Myogenic/Osteogenic Bipotency In Vitro by Fluorescence-Activated Cell Sorting from Human Fetal Muscle
(Elsevier, 2014)Summary Fluorescence-activated cell sorting (FACS) strategies to purify distinct cell types from the pool of fetal human myofiber-associated (hMFA) cells were developed. We demonstrate that cells expressing the satellite ... -
Isolation of Progenitors that Exhibit Myogenic/Osteogenic Bipotency In Vitro by Fluorescence-Activated Cell Sorting from Human Fetal Muscle
(Elsevier BV, 2014)Fluorescence-activated cell sorting (FACS) strategies to purify distinct cell types from the pool of fetal human myofiber-associated (hMFA) cells were developed. We demonstrate that cells expressing the satellite cell ... -
Isolation, Characterization, and Aggregation of a Structured Bacterial Matrix Precursor
(American Society for Biochemistry and Molecular Biology, 2013)Biofilms are surface-associated groups of microbial cells that are embedded in an extracellular matrix (ECM). The ECM is a network of biopolymers, mainly polysaccharides, proteins, and nucleic acids. ECM proteins serve a ...