Now showing items 27654-27673 of 56448

    • Islet Oxygen Consumption Rate (OCR) Dose Predicts Insulin Independence in Clinical Islet Autotransplantation 

      Papas, Klearchos K.; Bellin, Melena D.; Sutherland, David E. R.; Suszynski, Thomas M.; Kitzmann, Jennifer P.; Avgoustiniatos, Efstathios S.; Gruessner, Angelika C.; Mueller, Kathryn R.; Beilman, Gregory J.; Balamurugan, Appakalai N.; Loganathan, Gopalakrishnan; Colton, Clark K.; Koulmanda, Maria; Weir, Gordon C.; Wilhelm, Josh J.; Qian, Dajun; Niland, Joyce C.; Hering, Bernhard J. (Public Library of Science, 2015)
      Background: Reliable in vitro islet quality assessment assays that can be performed routinely, prospectively, and are able to predict clinical transplant outcomes are needed. In this paper we present data on the utility ...
    • Islet β cell mass in diabetes and how it relates to function, birth, and death 

      Weir, Gordon C; Bonner-Weir, Susan (Blackwell Publishing Ltd, 2013)
      In type 1 diabetes (T1D) β cell mass is markedly reduced by autoimmunity. Type 2 diabetes (T2D) results from inadequate β cell mass and function that can no longer compensate for insulin resistance. The reduction of β cell ...
    • Islets in Type 2 Diabetes: In Honor of Dr. Robert C. Turner 

      Bonner-Weir, Susan; O'Brien, Timothy D. (American Diabetes Association, 2008)
    • Ismat Chughtai, Progressive Literature and Formations of the Indo-Muslim Secular, 1911-1991 

      Jaffer, Sadaf (2015-09-08)
      This dissertation examines the life, work, and contexts of noted Urdu writer and Indian cultural critic Ismat Chughtai (1911-1991). By engaging in readings of Chughtai’s texts and contexts, this dissertation presents the ...
    • ISMB 2008 Toronto 

      Linial, Michal; Mesirov, Jill; Morrison McKay, B. J.; Rost, Burkhard (Public Library of Science, 2008)
      The International Society for Computational Biology (ISCB) presents the Sixteenth International Conference on Intelligent Systems for Molecular Biology (ISMB 2008), to be held in Toronto, Canada, July 19–23, 2008. Now ...
    • The ISO view of Palomar-Green quasars 

      Haas, M.; Klaas, U.; Müller, S. A. H.; Bertoldi, F.; Camenzind, M.; Chini, R.; Krause, O.; Lemke, D.; Meisenheimer, K.; Richards, P. J.; Wilkes, Belinda Jane (EDP Sciences, 2003)
      Mining the ISO data archive we provide the complete ISO view of PG quasars containing 64 infrared spectral energy distributions between 5 and 200 $\mu $m. About half of the sample was supplemented by MAMBO and SCUBA ...
    • The ISO-2MASS AGN survey: on the type-1 sources 

      Leipski, C.; Haas, M.; Meusinger, H.; Siebenmorgen, R.; Chini, R.; Scheyda, C. M.; Albrecht, M.; Wilkes, Belinda Jane; Huchra, J. P.; Ott, S.; Cesarsky, C.; Cutri, R. (EDP Sciences, 2005)
      We combined the ISOCAM Parallel Mode Survey at 6.7 micron (LW2 filter) with the Two Micron All Sky Survey in order to obtain a powerful tool to search for AGN independent of dust extinction. Using moderate colour criteria ...
    • Isoflurane-Induced Apoptosis: A Potential Pathogenic Link Between Delirium and Dementia 

      Xie, Zhongcong; Dong, Y.; Maeda, U.; Moir, Robert D.; Inouye, Sharon; Culley, Deborah Jean; Crosby, Gregory; Tanzi, Rudolph Emile (Oxford University Press (OUP), 2006)
      Background. Dementia and delirium have been postulated to share common pathophysiologic mechanisms; however, identification of these unifying mechanisms has remained elusive. The inhalation anesthetic isoflurane has been ...
    • Isogenic Human Pluripotent Stem Cell Models of Cardiovascular Disease-Associated Genetic Variation 

      Peters, Derek Tilghman (2016-03-30)
      A complex interplay of genetic and environmental factors underlies the development of common human diseases such as cardiovascular disease. Despite widespread use of existing medications, coronary heart disease (CHD), ...
    • Isolated branches in the phylogeny of Platyhelminthes 

      Laumer, Christopher E. (2015-03-06)
      This dissertation examines the early phylogenetic divergences of the phylum Platyhelminthes using molecular sequence data, with an emphasis on the placement and evolutionary significance of several enigmatic and largely ...
    • Isolated Capital Cities, Accountability and Corruption: Evidence from US States 

      Campante, Filipe Robin; Do, Quoc-Anh (American Economic Association, 2014)
      We show that isolated capital cities are robustly associated with greater levels of corruption across US states, in line with the view that this isolation reduces accountability. We then provide direct evidence that the ...
    • Isolated cell behavior drives the evolution of antibiotic resistance 

      Artemova, Tatiana; Gerardin, Ylaine; Dudley, Carmel; Vega, Nicole M; Gore, Jeff (John Wiley & Sons, Ltd, 2015)
      Bacterial antibiotic resistance is typically quantified by the minimum inhibitory concentration (MIC), which is defined as the minimal concentration of antibiotic that inhibits bacterial growth starting from a standard ...
    • Isolating Live Cells After High-Throughput, Long-Term, Time-Lapse Microscopy 

      Luro, Scott; Potvin-Trottier, Laurent; Okumus, Burak; Paulsson, Johan (Springer Science and Business Media LLC, 2019-11-25)
      Single-cell genetic screens can be incredibly powerful, but current high-throughput platforms do not track dynamics, and even for non-dynamic properties they struggle to separate mutants of interest from phenotypic outliers ...
    • Isolation and Analysis of Rare Norovirus Recombinants from Coinfected Mice Using Drop-Based Microfluidics 

      Zhang, Huidan; Cockrell, Shelley K.; Kolawole, Abimbola O.; Rotem, Assaf; Serohijos, Adrian; Chang, Connie B.; Tao, Ye; Mehoke, Thomas S.; Han, Yulong; Lin, Jeffrey S.; Giacobbi, Nicholas S.; Feldman, Andrew B.; Shakhnovich, Eugene Isaacovitch; Weitz, David A.; Wobus, Christiane E.; Pipas, James M. (American Society for Microbiology, 2015)
      Human noroviruses (HuNoVs) are positive-sense RNA viruses that can cause severe, highly infectious gastroenteritis. HuNoV outbreaks are frequently associated with recombination between circulating strains. Strain genotyping ...
    • Isolation and Characterization of Distal Lung Progenitor Cells 

      Driscoll, Barbara; Kikuchi, Alex; Lau, Allison N.; Lee, Jooeun; Reddy, Raghava; Jesudason, Edwin; Kim, Carla; Warburton, David (Humana Press, 2012-04-14)
      The majority of epithelial cells in the distal lung of rodents and humans are quiescent in vivo, yet certain cell populations retain an intrinsic capacity to proliferate and differentiate in response to lung injury or in ...
    • Isolation and characterization of novel RECK tumor suppressor gene splice variants 

      Trombetta-Lima, Marina; Winnischofer, Sheila Maria Brochado; Demasi, Marcos Angelo Almeida; Filho, Renato Astorino; Carreira, Ana Claudia Oliveira; Wei, Beiyang; de Assis Ribas, Thais; Konig, Michelle Silberspitz; Bowman-Colin, Christian; Oba-Shinjo, Sueli Mieko; Marie, Suely Kazue Nagahashi; Stetler-Stevenson, William; Sogayar, Mari Cleide (Impact Journals LLC, 2015)
      Glioblastoma multiforme is the most common and lethal of the central nervous system glial-derived tumors. RECK suppresses tumor invasion by negatively regulating at least three members of the matrix metalloproteinase family: ...
    • Isolation and co-culture of rat parenchymal and non-parenchymal liver cells to evaluate cellular interactions and response 

      Bale, Shyam Sundhar; Geerts, Sharon; Jindal, Rohit; Yarmush, Martin L. (Nature Publishing Group, 2016)
      The liver is a central organ in the human body, and first line of defense between host and external environment. Liver response to any external perturbation is a collective reaction of resident liver cells. Most of the ...
    • Isolation and Culture of Post-Natal Mouse Cerebellar Granule Neuron Progenitor Cells and Neurons 

      Lee, Hae Young; Greene, Lloyd A.; Mason, Carol A.; Manzini, Maria Chiara (Journal of Visualized Experiments, 2009)
      The cerebellar cortex is a well described structure that provides unique opportunities for studying neuronal properties and development. Of the cerebellar neuronal types (granule cells, Purkinje cells and inhibitory ...
    • Isolation and Economic Life in Eighteenth-Century France 

      Rothschild, Emma (Oxford University Press (OUP), 2014)