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Now showing items 28587-28606 of 56863
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Large Retroperitoneal Liposarcoma Diagnosed upon Radiological Evaluation of Mild Right-Sided Inguinal Hernia
(Hindawi Publishing Corporation, 2013)While inguinal hernia is common in the primary care office, the differential diagnosis is extensive and includes infectious, inflammatory and neoplastic processes. Varicocele is another frequent, generally benign condition ... -
Large Scale Association Analysis Identifies Three Susceptibility Loci for Coronary Artery Disease
(Public Library of Science, 2011)Genome wide association studies (GWAS) and their replications that have associated DNA variants with myocardial infarction (MI) and/or coronary artery disease (CAD) are predominantly based on populations of European or ... -
A Large Scale Gene-Centric Association Study of Lung Function in Newly-Hired Female Cotton Textile Workers with Endotoxin Exposure
(Public Library of Science, 2013)Background: Occupational exposure to endotoxin is associated with decrements in pulmonary function, but how much variation in this association is explained by genetic variants is not well understood. Objective: We aimed ... -
Large Scale Inference with Theoretical Guarantees under Various Distributed Settings
(2023-05-15)Large-scale inference under distributed settings is an essential problem in machine learning and statistical inference. In many applications, the amount of data is too large to be processed by a single machine, requiring ... -
Large Shareholders and Corporate Control
(University of Chicago Press, 1986)In a corporation with many small owners, it may not pay any one of them to monitor the performance of the management. We explore a model in which the presence of a large minority shareholder provides a partial solution to ... -
Large Spin Relaxation Rates in Trapped Submerged-Shell Atoms
(American Physical Society, 2010)Spin relaxation due to atom–atom collisions is measured for magnetically trapped erbium and thulium atoms at a temperature near 500 mK. The rate constants for Er–Er and Tm–Tm collisions are 3.0×10\(^{-10}\) and 1.1×10\(^{-10}\) ... -
Large Spinose Microfossils in Ediacaran Rocks as Resting Stages of Early Animals
(National Academy of Sciences, 2009)Large (> 100 mu m), profusely ornamented microfossils comprise a distinctive paleontological component of sedimentary rocks deposited during the Ediacaran Period (635-542 million years ago). Smaller spinose fossils in ... -
Large spontaneous emission enhancement in plasmonic nanocavities
(Nature Publishing Group, 2012)Cavity–emitter coupling can enable a host of potential appli- cations in quantum optics, from low-threshold lasers to brighter single-photon sources for quantum cryptography1. Although some of the first demonstrations of ... -
Large, Uni-directional Actuation in Dielectric Elastomers Achieved By Fiber Stiffening
(American Institute of Physics, 2012)Cylindrical actuators are made with dielectric elastomer sheets stiffened with fibers in the hoop direction. When a voltage is applied through the thickness of the sheets, large actuation strains are achievable in the axial ... -
Large-Effect Beneficial Synonymous Mutations Mediate Rapid and Parallel Adaptation in a Bacterium
(Oxford University Press, 2016)Contrary to previous understanding, recent evidence indicates that synonymous codon changes may sometimes face strong selection. However, it remains difficult to generalize the nature, strength, and mechanism(s) of such ... -
Large-N and vacuum alignment in top-color models
(American Physical Society (APS), 1998)Topcolor and topcolor-assisted technicolor provide examples of dynamical electroweak symmetry breaking which include top-condensation, thereby naturally incorporating a heavy top quark. In this note we discuss the roles ... -
Large-Scale Analysis of B-Cell Epitopes on Influenza Virus Hemagglutinin – Implications for Cross-Reactivity of Neutralizing Antibodies
(Frontiers Media S.A., 2014)Influenza viruses continue to cause substantial morbidity and mortality worldwide. Fast gene mutation on surface proteins of influenza virus result in increasing resistance to current vaccines and available antiviral drugs. ... -
Large-Scale Analysis of Microtubule Pharmacology via Phosphoproteomics and High-Content Imaging
(2018-08-17)The dynamic instability of microtubules is a critical phenomenon that regulates several biological processes. Chemical perturbation of microtubules disrupts these processes and is known to stimulate phosphorylation of ... -
Large-Scale Assessment of the Effect of Popularity on the Reliability of Research
(Public Library of Science, 2009)Based on theoretical reasoning it has been suggested that the reliability of findings published in the scientific literature decreases with the popularity of a research field. Here we provide empirical support for this ... -
Large-scale association analyses identify host factors influencing human gut microbiome composition
(SpringerNature, 2012-02-18) -
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
(2012)Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have raised the number of confirmed loci ... -
Large-Scale Association Analysis Provides Insights into the Genetic Architecture and Pathophysiology of Type 2 Diabetes
(Nature Publishing Group, 2012)To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip involving 34,840 cases and 114,981 controls, overwhelmingly ... -
Large-scale atomistic simulation at near-quantum accuracy with equivariant machine learning
(2023-11-21)Since the first digital computers were built, scientists have programmed them to make concrete predictions about real-world systems by numerically solving the relevant physical laws that govern the behavior of those systems. ... -
Large-Scale Chemical–genetics Yields New M. Tuberculosis Inhibitor Classes
(Springer Science and Business Media LLC, 2019-06-19)New antibiotics are needed to combat rising resistance, with new Mycobacterium tuberculosis (Mtb) drugs of highest priority. Conventional whole-cell and biochemical antibiotic screens have failed. We developed a novel ...