Now showing items 41858-41877 of 57357

    • PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities 

      Wolf, Gert; Trüb, Thomas; Ottinger, Elizabeth; Groninga, Lori; Lynch, Ann; White, Morris F.; Miyazaki, Masaya; Lee, Jongsoon; Shoelson, Steven E. (American Society for Biochemistry and Molecular Biology, 1995)
    • PTEN Negatively Regulates Engulfment of Apoptotic Cells by Modulating Activation of Rac GTPase 

      Mondal, Subhanjan; Ghosh-Roy, Saurabh; Loison, Fabien; Li, Yitang; Jia, Yonghui; Harris, Chad; Williams, David Allan; Luo, Hongbo (American Association of Immunologists, 2011)
      Efficient clearance of apoptotic cells by phagocytes (efferocytosis) is critical for normal tissue homeostasis and regulation of the immune system. Apoptotic cells are recognized by a vast repertoire of receptors on ...
    • The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment 

      Sharma, Madhav D.; Shinde, Rahul; McGaha, Tracy L.; Huang, Lei; Holmgaard, Rikke B.; Wolchok, Jedd D.; Mautino, Mario R.; Celis, Esteban; Sharpe, Arlene H.; Francisco, Loise M.; Powell, Jonathan D.; Yagita, Hideo; Mellor, Andrew L.; Blazar, Bruce R.; Munn, David H. (American Association for the Advancement of Science, 2015)
      The tumor microenvironment is profoundly immunosuppressive. We show that multiple tumor types create intratumoral immune suppression driven by a specialized form of regulatory T cell (Treg) activation dependent on the PTEN ...
    • PTFOS: Flexible and Absorbable Intracranial Electrodes for Magnetic Resonance Imaging 

      Bonmassar, Giorgio; Fujimoto, Kyoko; Golby, Alexandra Jacqueline (Public Library of Science, 2012)
      Intracranial electrocortical recording and stimulation can provide unique knowledge about functional brain anatomy in patients undergoing brain surgery. This approach is commonly used in the treatment of medically refractory ...
    • PTGER4 Expression-Modulating Polymorphisms in the 5p13.1 Region Predispose to Crohn's Disease and Affect NF-κB and XBP1 Binding Sites 

      Glas, Jürgen; Seiderer, Julia; Czamara, Darina; Pasciuto, Giulia; Diegelmann, Julia; Wetzke, Martin; Olszak, Torsten; Wolf, Christiane; Müller-Myhsok, Bertram; Balschun, Tobias; Achkar, Jean-Paul; Kamboh, M. Ilyas; Franke, Andre; Duerr, Richard H.; Brand, Stephan (Public Library of Science, 2012)
      Background: Genome-wide association studies identified a PTGER4 expression-modulating region on chromosome 5p13.1 as Crohn's disease (CD) susceptibility region. The study aim was to test this association in a large cohort ...
    • PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3) 

      Dossus, Laure; Kaaks, Rudolf; Canzian, Federico; Albanes, Demetrius; Berndt, Sonja I.; Boeing, Heiner; Buring, Julie; Chanock, Stephen J.; Clavel-Chapelon, Francoise; Feigelson, Heather Spencer; Gaziano, John M.; Giovannucci, Edward; Gonzalez, Carlos; Haiman, Christopher A.; Hallmans, Göran; Hankinson, Susan E.; Hayes, Richard B.; Henderson, Brian E.; Hoover, Robert N.; Hunter, David J.; Khaw, Kay-Tee; Kolonel, Laurence N.; Kraft, Peter; Ma, Jing; Marchand, Loic Le; Lund, Eiliv; Peeters, Petra H. M.; Stampfer, Meir; Stram, Dan O.; Thomas, Gilles; Thun, Michael J.; Tjonneland, Anne; Trichopoulos, Dimitrios; Tumino, Rosario; Riboli, Elio; Virtamo, Jarmo; Weinstein, Stephanie J.; Yeager, Meredith; Ziegler, Regina G.; Cox, David G. (Oxford University Press, 2010)
      Genes involved in the inflammation pathway have been associated with cancer risk. Genetic variants in the interleukin-6 (IL6) and prostaglandin-endoperoxide synthase-2 (PTGS2, encoding for the COX-2 enzyme) genes, in ...
    • PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival 

      Iida, Naoko; Zou, Lihua; Yao, Jun; Lu, Yiling; Epstein, Charles B.; Natesan, Sridaran; Mills, Gordon B.; Irie, Hanna Yoko; Shrestha, Yashaswi; Selfors, Laura Marie; Frye, Fabianne; Wang, Zhigang C.; Richardson, Andrea Lynn; Polyak, Kornelia; Hahn, William C.; Brugge, Joan S. (Public Library of Science, 2010)
      Background: Proteins that are required for anchorage-independent survival of tumor cells represent attractive targets for therapeutic intervention since this property is believed to be critical for survival of tumor cells ...
    • PTK7+Mononuclear Cells Express VEGFR2 and Contribute to Vascular Stabilization by Upregulating Angiopoietin-1Significance 

      Chauhan, Sunil Kumar; Lee, Hyung Keun; Lee, Hyun Soo; Park, Eun Young; Jeong, Eunae; Dana, Reza (Ovid Technologies (Wolters Kluwer Health), 2015)
      Objective In angiogenesis, circulating mononuclear cells are recruited to vascular lesions; however, the underlying mechanisms are poorly understood. Approach and Results Here, we characterize the functional role ...
    • PTP1B regulates non-mitochondrial oxygen consumption via RNF213 to promote tumour survival during hypoxia 

      Banh, Robert S.; Iorio, Caterina; Marcotte, Richard; Xu, Yang; Cojocari, Dan; Rahman, Anas Abdel; Pawling, Judy; Zhang, Wei; Sinha, Ankit; Rose, Christopher M.; Isasa, Marta; Zhang, Shuang; Wu, Ronald; Virtanen, Carl; Hitomi, Toshiaki; Habu, Toshiyuki; Sidhu, Sachdev S.; Koizumi, Akio; Wilkins, Sarah E.; Kislinger, Thomas; Gygi, Steven P.; Schofield, Christopher J.; Dennis, James W.; Wouters, Bradly G.; Neel, Benjamin G. (2016)
      Tumours exist in a hypoxic microenvironment and must limit excessive oxygen consumption. Hypoxia-inducible factor controls mitochondrial oxygen consumption, but how/if tumours regulate non-mitochondrial oxygen consumption ...
    • PTP1B triggers integrin-mediated repression of myosin activity and modulates cell contractility 

      González Wusener, Ana E.; González, Ángela; Nakamura, Fumihiko; Arregui, Carlos O. (The Company of Biologists Ltd, 2016)
      ABSTRACT Cell contractility and migration by integrins depends on precise regulation of protein tyrosine kinase and Rho-family GTPase activities in specific spatiotemporal patterns. Here we show that protein tyrosine ...
    • PTPN11-Associated Mutations in the Heart: Has LEOPARD Changed Its RASpots? 

      Lauriol, Jessica; Kontaridis, Maria Irene (Elsevier BV, 2011)
      In this review, we focus on elucidating the cardiac function of germline mutations in the PTPN11 gene, encoding the Src homology-2 (SH2) domain-containing protein tyrosine phosphatase SHP2. PTPN11 mutations cause LEOPARD ...
    • Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice 

      Fraser, Heather I.; Howlett, Sarah; Clark, Jan; Rainbow, Daniel B.; Stanford, Stephanie M.; Wu, Dennis J.; Hsieh, Yi-Wen; Maine, Christian J.; Christensen, Mikkel; Kuchroo, Vijay; Sherman, Linda A.; Podolin, Patricia L.; Todd, John A.; Steward, Charles A.; Peterson, Laurence B.; Bottini, Nunzio; Wicker, Linda S. (AAI, 2015)
      By congenic strain mapping using autoimmune NOD.C57BL/6J congenic mice, we demonstrated previously that the type 1 diabetes (T1D) protection associated with the insulin-dependent diabetes (Idd)10 locus on chromosome 3, ...
    • PTPN22 Silencing in the NOD Model Indicates the Type 1 Diabetes–Associated Allele Is Not a Loss-of-Function Variant 

      Zheng, Peilin; Kissler, Stephan (American Diabetes Association, 2013)
      PTPN22 encodes the lymphoid tyrosine phosphatase (LYP) and is the second strongest non-HLA genetic risk factor for type 1 diabetes. The PTPN22 susceptibility allele generates an LYP variant with an arginine-to-tryptophan ...
    • PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis 

      Chang, Hui-Hsin; Tai, Tzong-Shyuan; Lu, Bing; Iannaccone, Christine; Cernadas, Manuela; Weinblatt, Michael Elliott; Shadick, Nancy Ann; Miaw, Shi-Chuen; Ho, I-Cheng (Public Library of Science, 2012)
      PTPN22 is a tyrosine phosphatase and functions as a damper of TCR signals. A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human PTPN22 cDNA and converting an arginine (R620) to tryptophan (W620) ...
    • PTSD and DNA Methylation in Select Immune Function Gene Promoter Regions: A Repeated Measures Case-Control Study of U.S. Military Service Members 

      Rusiecki, Jennifer A.; Byrne, Celia; Galdzicki, Zygmunt; Srikantan, Vasantha; Chen, Ligong; Poulin, Matthew; Yan, Liying; Baccarelli, Andrea (Frontiers Media S.A., 2013)
      Background: The underlying molecular mechanisms of PTSD are largely unknown. Distinct expression signatures for PTSD have been found, in particular for immune activation transcripts. DNA methylation may be significant in ...
    • PTSD Modifies Performance on a Task of Affective Executive Control among Deployed OEF/OIF Veterans with Mild Traumatic Brain Injury 

      Amick, Melissa M.; Clark, Alexandra; Fortier, Catherine B.; Esterman, Michael; Rasmusson, Ann M.; Kenna, Alexandra; Milberg, William P.; McGlinchey, Regina (Cambridge University Press, 2013)
      Individuals with post-traumatic stress disorder (PTSD) show a cognitive bias for threatening information, reflecting dysregulated executive control for affective stimuli. This study examined whether comorbid mild Traumatic ...
    • PTSD Symptoms: Romantic Relationships with Individuals Who Have Narcissistic and Psychopathic Traits 

      Arabi, Shahida (2022-05-12)
      Research has only begun to explore the mental health implications of being involved in romantic relationships with individuals who have narcissistic and psychopathic traits. Current research indicates that involvement in ...
    • Public Acceptance and Willingness-to-Pay for a Future Dengue Vaccine: A Community-Based Survey in Bandung, Indonesia 

      Hadisoemarto, Panji Fortuna; Castro, Marcia C. (Public Library of Science, 2013)
      Background: All four serotypes of dengue virus are endemic in Indonesia, where the population at risk for infection exceeds 200 million people. Despite continuous control efforts that were initiated more than four decades ...
    • Public access to federally funded research: The Cornyn-Lieberman and CURES bills 

      English, Ray; Suber, Peter (Association of College and Research Libraries, 2006)
    • Public Access to Genome-Wide Data: Five Views on Balancing Research with Privacy and Protection 

      P3G Consortium; Church, George McDonald; Heeney, Catherine; Hawkins, Naomi; de Vries, Jantina; Boddington, Paula; Kaye, Jane; Bobrow, Martin; Weir, Bruce (Public Library of Science, 2009)
      Introductory paragraph: Just over twelve months ago, PLoS Genetics published a paper [1] demonstrating that, given genome-wide genotype data from an individual, it is, in principle, possible to ascertain whether that ...