Now showing items 42286-42305 of 57727

    • Putting up and Putting Down: Tolerance Reconsidered 

      Minow, Martha Louise (1990)
    • Puzzle Imaging: Using Large-Scale Dimensionality Reduction Algorithms for Localization 

      Glaser, Joshua I.; Zamft, Bradley M.; Church, George M.; Kording, Konrad P. (Public Library of Science, 2015)
      Current high-resolution imaging techniques require an intact sample that preserves spatial relationships. We here present a novel approach, “puzzle imaging,” that allows imaging a spatially scrambled sample. This technique ...
    • The Puzzle of Democratic Monopolies: Single Party Dominance and Decline in India 

      Dasgupta, Aditya (2016-05-12)
      How to explain political monopolies in democratic institutional settings? Dominant parties in countries with robust formal democratic institutions are surprisingly frequent, yet poorly understood. Existing theories explain ...
    • The Puzzle of Positive Results — Myocardial Revascularization 

      Jones, David Shumway (New England Journal of Medicine (NEJM/MMS), 2015)
      The coronary-sinus reduction described by Verheye et al. revives an old therapeutic concept. For many decades, physicians have been designing surgical interventions against coronary artery disease and trying them in patients ...
    • The puzzle of the steady-state rotation of a reverse sprinkler 

      Rueckner, Wolfgang H. E. (American Association of Physics Teachers (AAPT), 2015)
      The continuous rotation of the reverse sprinkler has been a puzzle for over two decades. This article presents a series of experiments that demonstrate that a properly designed reverse sprinkler experiences no steady-state ...
    • PVS: A Web Server for Protein Sequence Variability Analysis Tuned to Facilitate Conserved Epitope Discovery 

      Garcia-Boronat, Maria; Diez-Rivero, Carmen M.; Reinherz, Ellis Leonard; Reche, Pedro A. (Oxford University Press, 2008)
      We have developed PVS (Protein Variability Server), a web-based tool that uses several variability metrics to compute the absolute site variability in multiple protein-sequence alignments (MSAs). The variability is then ...
    • PyBio: An Open Source Bioinformatics Library for Python. 

      Ellis, Jon R. (2016-06-25)
      PyBio is an easy-to-install, open-source library for working with bioinformatics data in Python, designed to encourage interactive data exploration and scripting. The Pybio API is designed to be explorable in an IPython ...
    • Pyocyanin-Enhanced Neutrophil Extracellular Trap Formation Requires the NADPH Oxidase 

      Rada, Balázs; Jendrysik, Meghan A.; Pang, Lan; Hayes, Craig P.; Yoo, Dae-goon; Park, Jonathan J.; Moskowitz, Samuel M; Malech, Harry L.; Leto, Thomas L. (Public Library of Science, 2013)
      Beyond intracellular killing, a novel neutrophil-based antimicrobial mechanism has been recently discovered: entrapment and killing by neutrophil extracellular traps (NETs). NETs consist of extruded nuclear DNA webs decorated ...
    • PyPanda: a Python package for gene regulatory network reconstruction 

      van IJzendoorn, David G.P.; Glass, Kimberly; Quackenbush, John; Kuijjer, Marieke L. (Oxford University Press, 2016)
      Summary: PANDA (Passing Attributes between Networks for Data Assimilation) is a gene regulatory network inference method that uses message-passing to integrate multiple sources of ‘omics data. PANDA was originally coded ...
    • Pyramid Capitalism: Cronyism, Regulation, and Firm Productivity in Egypt 

      Diwan, Ishac; Keefer, Philip; Schiffbauer, Marc (Center for International Development at Harvard University, 2015-03)
      Using an original database of 469 politically connected firms under the Mubarak regime in Egypt, we explore the economic effects of cronyism. Previous research has shown that cronyism is lucrative. We address numerous ...
    • Pyrazinamide Resistance Assays and Two-Month Sputum Culture Status in Patients with Multidrug-Resistant Tuberculosis 

      Velásquez, Gustavo E.; Calderon, Roger; Mitnick, Carole; Becerra, Mercedes; Huang, Chuan-Chin; Zhang, Zibiao; Contreras, Carmen; Yataco, Rosa; Galea, Jerome; Lecca, Leonid; Murray, Megan (American Society for Microbiology, 2016)
      Phenotypic drug susceptibility testing is the current "gold standard" for detecting Mycobacterium tuberculosis susceptibility to antituberculous drugs. Pyrazinamide is one antituberculous drug for which the correlation ...
    • Pyrin Modulates the Intracellular Distribution of PSTPIP1 

      Waite, Andrea L.; Schaner, Philip; Richards, Neil; Balci-Peynircioglu, Banu; Masters, Seth L.; Brydges, Susannah D.; Hong, Arthur; Yilmaz, Engin; Kastner, Daniel L.; Gumucio, Deborah L.; May, Robin Charles; Fox, Michelle; Reinherz, Ellis Leonard (Public Library of Science, 2009)
      PSTPIP1 is a cytoskeleton-associated adaptor protein that links PEST-type phosphatases to their substrates. Mutations in PSTPIP1 cause PAPA syndrome (Pyogenic sterile Arthritis, Pyoderma gangrenosum, and Acne), an ...
    • Pyrosequencing Evaluation of Widely Available Bisulfite Conversion Methods: Considerations for Application 

      Izzi, Benedetta; Binder, Alexandra M.; Michels, Karin B. (2014)
      Introduction: Bisulfite treatment of DNA introduces methylation-dependent sequence changes through selective chemical conversion of nonmethylated cytosine to uracil and serves as pretreatment step for the majority of DNA ...
    • Pyrovanadolysis, a Pyrophosphorolysis-like Reaction Mediated by Pyrovanadate, Mn2+, and DNA Polymerase of Bacteriophage T7 

      Akabayov, Barak; Kulczyk, Arkadiusz W.; Akabayov, Sabine R.; Theile, Christopher; McLaughlin, Larry W.; Beauchamp, Benjamin; Oijen, Antoine van; Richardson, Charles C. (American Society for Biochemistry and Molecular Biology, 2011)
      DNA polymerases catalyze the 3'-5'-pyrophosphorolysis of a DNA primer annealed to a DNA template in the presence of pyrophosphate (PPi). In this reversal of the polymerization reaction, deoxynucleotides in DNA are converted ...
    • Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis 

      Anastasiou, Dimitrios; Yu, Yimin; Israelsen, William J.; Jiang, Jian-kang; Boxer, Matthew B.; Hong, Bum Soo; Tempel, Wolfram; Dimov, Svetoslav; Shen, Min; Jha, Abhishek; Yang, Hua; Mattaini, Katherine R.; Metallo, Christian M.; Fiske, Brian P.; Courtney, Kevin D.; Malstrom, Scott; Khan, Tahsin M.; Kung, Charles; Skoumbourdis, Amanda P.; Veith, Henrike; Southall, Noel; Walsh, Martin J.; Brimacombe, Kyle R.; Leister, William; Lunt, Sophia Y.; Johnson, Zachary R.; Yen, Katharine E.; Kunii, Kaiko; Davidson, Shawn M.; Christofk, Heather R.; Austin, Christopher P.; Inglese, James; Harris, Marian H.; Asara, John M.; Stephanopoulos, Gregory; Salituro, Francesco G.; Jin, Shengfang; Dang, Lenny; Auld, Douglas S.; Park, Hee-Won; Cantley, Lewis C.; Thomas, Craig J.; Vander Heiden, Matthew G. (2012)
      Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer. PKM2 interaction ...
    • PZR Coordinates Shp2 Noonan and LEOPARD Syndrome Signaling in Zebrafish and Mice 

      Paardekooper Overman, J.; Yi, J.-S.; Bonetti, M.; Soulsby, M.; Preisinger, C.; Stokes, Marquita Lavelle; Hui, L.; Silva, J. C.; Overvoorde, J.; Giansanti, P.; Heck, A. J. R.; Kontaridis, Maria Irene; den Hertog, J.; Bennett, A. M. (American Society for Microbiology, 2014)
      Noonan syndrome (NS) is an autosomal dominant disorder caused by activating mutations in the PTPN11 gene encoding Shp2, which manifests in congenital heart disease, short stature, and facial dysmorphia. The complexity of ...
    • Q&A: Epistasis 

      Roth, Frederick Phillip; Lipshitz, Howard D; Andrews, Brenda J (BioMed Central, 2009)
    • q-deformed Interacting Particle Systems, RSKs and Random Polymers 

      Matveev, Konstantin (2016-04-28)
      We introduce and study four $q$-randomized Robinson--Schensted--Knuth (RSK) insertion tableau dynamics. Each of them is a discrete time Markov dynamics on two-dimensional interlacing particle arrays (these arrays are in ...
    • QCD on the Connection Machine: Beyond *LISP 

      Brickner, Ralph G.; Baillie, Clive F.; Johnsson, S. Lennart (1991)
      We report on the status of code development for a simulation of Quantum Chromodynamics (QCD) with dynamical Wilson fermions on the Connection Machine model CM-2. Our original code, written in *Lisp, gave performance in the ...
    • QCVis: A Quantum Circuit Visualization and Education Platform for Novices 

      Williams, Milan Marie (2021-06-03)
      QCVis is a quantum circuit visualization and education platform for novices. The rapid growth of the quantum computing field surpasses the educational capacity of existing systems, which makes novices particularly in need ...