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Now showing items 42531-42550 of 58455

    • PS1-10afx at z = 1.388: Pan-STARRS1 Discovery of a New Type of Superluminous Supernova 

      Chornock, Ryan T.; Berger, Edo; Rest, A.; Milisavljevic, Danny; Lunnan, Ragnhild; Foley, R. J.; Soderberg, Alicia M.; Smartt, S. J.; Burgasser, A. J.; Challis, Peter M.; Chomiuk, L.; Czekala, Ian Philip; Drout, Maria Rebecca; Fong, Wen-fai; Huber, M. E.; Kirshner, Robert P.; Leibler, C.; McLeod, Brian A.; Marion, G. H.; Narayan, Gautham Siddharth; Riess, A. G.; Roth, K. C.; Sanders, Nathan Edward; Scolnic, D.; Smith, K.; Stubbs, Christopher William; Tonry, J. L.; Valenti, S.; Burgett, W. S.; Chambers, K. C.; Hodapp, K. W.; Kaiser, N.; Kudritzki, R.-P.; Magnier, E. A.; Price, P. A. (American Astronomical Society, 2013)
      We present the Pan-STARRS1 discovery of PS1-10afx, a unique hydrogen-deficient superluminous supernova (SLSN) at redshift z = 1.388. The light curve peaked at z P1 = 21.7 mag, making PS1-10afx comparable to the most luminous ...

    • Ps1-10bzj: A Fast, Hydrogen-Poor Superluminous Supernova in a Metal Poor Host Galaxy 

      Lunnan, R; Chornock, R; Berger, Edo; Milisavljevic, Danny; Drout, Maria Rebecca; Sanders, Nathan Edward; Challis, P. M.; Czekala, I.; Foley, R. J.; Fong, W.; Huber, M. E.; Kirshner, R. P.; Leibler, C.; Marion, G. H.; McCrum, M.; Narayan, G.; Rest, A.; Roth, K. C.; Scolnic, D.; Smartt, S. J.; Smith, K.; Soderberg, Alicia M.; Stubbs, Christopher William; Tonry, J. L.; Burgett, W. S.; Chambers, K. C.; Kudritzki, R.-P.; Magnier, E. A.; Price, P. A. (IOP Publishing, 2013)
      We present observations and analysis of PS1-10bzj, a superluminous supernova (SLSN) discovered in the Pan-STARRS Medium Deep Survey at a redshift z = 0.650. Spectroscopically, PS1-10bzj is similar to the hydrogen-poor SLSNe ...

    • Ps1-10jh Continues to Follow the Fallback Accretion Rate of a Tidally Disrupted Star 

      Gezari, S.; Chornock, R.; Lawrence, A.; Rest, A.; Jones, D. O.; Berger, Edo; Challis, P. M.; Narayan, G. (IOP Publishing, 2015)
      We present late-time observations of the tidal disruption event candidate PS1-10jh. UV and optical imaging with HST/WFC3 localize the transient to be coincident with the host galaxy nucleus to an accuracy of 0.023 arcsec, ...

    • Ps1-12sk Is a Peculiar Supernova From a He-Rich Progenitor System in a Brightest Cluster Galaxy Environment 

      Sanders, Nathan Edward; Soderberg, Alicia M.; Foley, R. J.; Chornock, R; Milisavljevic, Danny; Margutti, R; Drout, Maria Rebecca; Moe, M; Berger, Edo; Brown, W. R.; Lunnan, R.; Smartt, S. J.; Fraser, M.; Kotak, R.; Magill, L.; Smith, K. W.; Wright, D.; Huang, K.; Urata, Y.; Mulchaey, J. S.; Rest, A.; Sand, D. J.; Chomiuk, L.; Friedman, A. S.; Kirshner, R. P.; Marion, G. H.; Tonry, J. L.; Burgett, W. S.; Chambers, K. C.; Hodapp, K. W.; Kudritzki, R. P.; Price, P. A. (IOP Publishing, 2013)
      We report on our discovery and observations of the Pan-STARRS1 supernova (SN) PS1-12sk, a transient with properties that indicate atypical star formation in its host galaxy cluster or pose a challenge to popular progenitor ...

    • PS1-14bj: A Hydrogen-poor Superluminous Supernova with a Long Rise and Slow Decay. 

      Lunnan, R.; Chornock, R.; Berger, Edo; Milisavljevic, Danny; Jones, D. O.; Rest, A.; Fong, W.; Fransson, C.; Margutti, R.; Drout, M. R.; Blanchard, Peter Kelly; Challis, P.; Cowperthwaite, Philip Steven; Foley, R. J.; Kirshner, Robert P.; Morrell, N.; Riess, A. G.; Roth, K. C.; Scolnic, D.; Smartt, S. J.; Smith, K. W.; Villar, Victoria Ashley; Chambers, K. C.; Draper, P. W.; Huber, M. E.; Kaiser, N.; Kudritzki, R.-P.; Magnier, E. A.; Metcalfe, N.; Waters, C. (American Astronomical Society, 2016)
      We present photometry and spectroscopy of PS1-14bj, a hydrogen-poor superluminous supernova (SLSN) at redshift z = 0.5215 discovered in the last months of the Pan-STARRS1 Medium Deep Survey. PS1-14bj stands out by its ...

    • PS341 inhibits hepatocellular and colorectal cancer cells through the FOXO3/CTNNB1 signaling pathway 

      Yang, Zhao; Liu, Shengwu; Zhu, Mingao; Zhang, Hong; Wang, Ji; Xu, Qian; Lin, Kaisu; Zhou, Xiumin; Tao, Min; Li, Chong; Zhu, Hong (Nature Publishing Group, 2016)
      Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) are among the most common cancers across the world. Particularly, a large number of patients with CRC also have liver metastasis. Currently, there are just a few ...

    • The PSEN1, p.E318G Variant Increases the Risk of Alzheimer's Disease in APOE-ε4 Carriers 

      Benitez, Bruno A.; Karch, Celeste M.; Cai, Yefei; Jin, Sheng Chih; Cooper, Breanna; Carrell, David; Bertelsen, Sarah; Chibnik, Lori; Schneider, Julie A.; Bennett, David A.; Fagan, Anne M.; Holtzman, David; Morris, John C.; Goate, Alison M.; Cruchaga, Carlos (Public Library of Science, 2013)
      The primary constituents of plaques (Aβ42/Aβ40) and neurofibrillary tangles (tau and phosphorylated forms of tau [ptau]) are the current leading diagnostic and prognostic cerebrospinal fluid (CSF) biomarkers for AD. In ...

    • A pseudo-Homer gets exposed by Homer 

      Nagy, Gregory (Harvard University, Center for Hellenic Studies, 2015-06-24)

    • Pseudo-set framing 

      Barasz, Kate; John, Leslie; Keenan, Elizabeth Ann; Norton, Michael (American Psychological Association (APA), 2017-10)
      Pseudo-set framing—arbitrarily grouping items or tasks together as part of an apparent “set”—motivates people to reach perceived completion points. Pseudo-set framing changes gambling choices (Study 1), effort (Studies 2 ...

    • Pseudoephenamine: A Practical Chiral Auixiliary for Asymmetric Synthesis 

      Morales Santos, Marvin Rocael (2013-02-25)
      Pseudoephedrine has been used as a chiral auxiliary in diastereoselective alkylation reactions, providing easy access to enantiomerically enriched carboxylic acids, alcohols, ketones, and aldehydes. Because pseudoephedrine ...

    • Pseudoephenamine: A Practical Chiral Auxiliary for Asymmetric Synthesis 

      Morales, Marvin R.; Mellem, Kevin T; Myers, Andrew G. (Wiley-VCH Verlag Berlin, 2012)
      Pseudoephenamine is shown to be a versatile chiral auxiliary for asymmetric synthesis. It is free from regulatory restrictions and exhibits remarkable stereocontrol in alkylation reactions, especially those that form ...

    • Pseudogenes in Human Cancer 

      Poliseno, Laura; Marranci, Andrea; Pandolfi, Pier Paolo (Frontiers Media S.A., 2015)
      Recent advances in the analysis of RNA sequencing data have shown that pseudogenes are highly specific markers of cell identity and can be used as diagnostic and prognostic markers. Furthermore, genetically engineered mouse ...

    • Pseudologia Fantastica in the Emergency Department: A Case Report and Review of the Literature 

      Thom, Robyn Pauline; Teslyar, Polina; Friedman, Rohn (Hindawi Publishing Corporation, 2017)
      Psychiatrists commonly encounter deception in the emergency department. This article presents the case of a patient who presents to the emergency department with an unusual and elaborate web of deceptions along multiple ...

    • Pseudomembranous Collagenous Colitis: A Case of Not-so-Microscopic Colitis 

      Grunwald, Douglas; Mehta, Manisha; Sheth, Sunil G. (American College of Gastroenterology, 2016)
      We present a 72-year-old male who developed progressive, watery diarrhea despite anti-motility agents. On colonoscopy, the mucosa was inflamed and covered with an exudate. Stool studies for Clostridium difficile and ...

    • Pseudomonas Aeruginosa Inducing Nociception Increases Susceptibility to Bacterial Keratitis 

      Lin, Tiffany (2019-02-07)
      Understanding nociceptive signaling during Pseudomonas keratitis and its impact on the immune response can prove to be useful for this very painful infection. While the cornea is one of the mostly densely innervated organs ...

    • Pseudomonas aeruginosa Infection of Zebrafish Involves both Host and Pathogen Determinants 

      Clatworthy, Anne; Lee, Jenny See-Wai; Leibman, Mark; Kostun, Zachary; Davidson, Alan; Hung, Deborah (American Society for Microbiology, 2009)
      Zebrafish (Danio rerio) have a number of strengths as a host model for infection, including genetic tractability, a vertebrate immune system similar to that of mammals, ease and scale of laboratory handling, which allows ...

    • Pseudomonas aeruginosa keratitis misdiagnosed as fungal keratitis by in vivo confocal microscopy: a case report 

      Hong, Jiaxu; Le, Qihua; Deng, Sophie X; Cao, Wenjun; Xu, Jianjiang (BioMed Central, 2014)
      Background: To report a case of non-typical Pseudomonas aeruginosa keratitis that was misdiagnosed as fungal keratitis by in vivo confocal microscopy. Case presentation: A 37-year-old Chinese woman presented with a 2-week ...

    • Pseudomonas aeruginosa Pore-Forming Exolysin and Type IV Pili Cooperate To Induce Host Cell Lysis 

      Basso, Pauline; Ragno, Michel; Elsen, Sylvie; Reboud, Emeline; Golovkine, Guillaume; Bouillot, Stephanie; Huber, Philippe; Lory, Stephen; Faudry, Eric; Attrée, Ina (American Society for Microbiology, 2017)
      ABSTRACT Clinical strains of Pseudomonas aeruginosa lacking the type III secretion system genes employ a toxin, exolysin (ExlA), for host cell membrane disruption. Here, we demonstrated that ExlA export requires a predicted ...

    • Pseudomonas aeruginosa RhlR is required to neutralize the cellular immune response in a Drosophila melanogaster oral infection model 

      Limmer, Stefanie; Haller, Samantha; Drenkard, Eliana; Lee, Janice; Yu, Shen; Kocks, Christine; Ausubel, Frederick M.; Ferrandon, Dominique (National Academy of Sciences, 2011)
      An in-depth mechanistic understanding of microbial infection necessitates a molecular dissection of host-pathogen relationships. Both Drosophila melanogaster and Pseudomonas aeruginosa have been intensively studied. Here, ...

    • Pseudomonas syringae manipulates systemic plant defenses against pathogens and herbivores 

      Cui, Jianping; Bahrami, Adam K.; Pringle, Elizabeth G.; Hernandez-Guzman, Gustavo; Bender, Carol L.; Pierce, Naomi E.; Ausubel, Frederick M. (National Academy of Sciences, 2005)
      Many pathogens are virulent because they specifically interfere with host defense responses and therefore can proliferate. Here, we report that virulent strains of the bacterial phytopathogen Pseudomonas syringae induce ...