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Quantitative Computed Tomographic Descriptors Associate Tumor Shape Complexity and Intratumor Heterogeneity with Prognosis in Lung Adenocarcinoma
(Public Library of Science, 2015)Two CT features were developed to quantitatively describe lung adenocarcinomas by scoring tumor shape complexity (feature 1: convexity) and intratumor density variation (feature 2: entropy ratio) in routinely obtained ... -
Quantitative contrast-enhanced CT attenuation evaluation of osseous metastases following chemotherapy
(Springer Nature, 2017)Purpose: Osseous metastases often undergo an osteoblastic response following chemotherapy also known as the “flare” phenomenon. The purpose of our study was to demonstrate the quantitative CT changes in density of osseous ... -
Quantitative deep sequencing reveals dynamic HIV-1 escape and large population shifts during CCR5 antagonist therapy in vivo
(Public Library of Science, 2009)High-throughput sequencing platforms provide an approach for detecting rare HIV-1 variants and documenting more fully quasispecies diversity. We applied this technology to the V3 loop-coding region of env in samples collected ... -
Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step
(eLife Sciences Publications, Ltd, 2014)Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for ... -
Quantitative effect of target translation on small RNA efficacy reveals a novel mode of interaction
(Oxford University Press, 2014)Small regulatory RNAs (sRNAs) in bacteria regulate many important cellular activities under normal conditions and in response to stress. Many sRNAs bind to the mRNA targets at or near the 5′ untranslated region (UTR) ... -
A Quantitative Electrophysiological Biomarker of Duplication 15q11.2-q13.1 Syndrome
(Public Library of Science, 2016)Background: Duplications of 15q11.2-q13.1 (Dup15q syndrome) are highly penetrant for autism spectrum disorder (ASD). A distinct electrophysiological (EEG) pattern characterized by excessive activity in the beta band has ... -
The Quantitative Empirics of Redistricting Litigation: Knowledge, Threats to Knowledge, and the Need for Less Districting
(Yale Law School, 2011)The experience of the past 50 years has taught us important lessons about the advancement in, but also the ultimate limits of, the quantitative empirics of redistricting. I provide a bird's eye view of the state of ... -
Quantitative Evaluation of Cobalt Disilicide/Si Interfacial Roughness
(The Electrochemical Society, 2017)The formation of smooth, conformal cobalt disilicide (CoSi2) without facets or voids is critical for microelectronic device reliability owing to the ultra-shallow contact areas. Here we demonstrate the formation of smooth ... -
Quantitative Evaluation of Performance in Interventional Neuroradiology: An Integrated Curriculum Featuring Theoretical and Practical Challenges
(Public Library of Science, 2016)Purpose We sought to develop a standardized curriculum capable of assessing key competencies in Interventional Neuroradiology by the use of models and simulators in an objective, quantitative, and efficient way. In this ... -
Quantitative examination of a novel clustering method using magnetic resonance diffusion tensor tractography
(Elsevier BV, 2009)MR diffusion tensor imaging (DTI) can measure and visualize organization of white matter fibre tracts in vivo. DTI is a relatively new imaging technique, and new tools developed for quantifying fibre tracts require evaluation. ... -
Quantitative Imaging Analysis of Non-Small Cell Lung Cancer
(2016-05-17)Quantitative imaging is a rapidly growing area of interest within the field of bioinformatics and biomarker discovery. Due to the routine nature of medical imaging, there is an abundance of high-quality imaging linked to ... -
Quantitative Investigation of the Effect of the Extra-Cerebral Vasculature in Diffuse Optical Imaging: A Simulation Study
(Optical Society of America, 2011)Diffuse optical imaging (DOI) is a non invasive technique allowing the recovery of hemodynamic changes in the brain. Due to the diffusive nature of photon propagation in turbid media and the fact that cerebral tissues are ... -
Quantitative Methods and Ethics
(Oxford University Press, 2013)The purpose of this chapter is to provide a context for thinking about the role of ethics in quantitative methodology.We begin by reviewing the sweep of events that led to the creation and expansion of legal and professional ... -
The Quantitative Methods Boot Camp: Teaching Quantitative Thinking and Computing Skills to Graduate Students in the Life Sciences
(Public Library of Science, 2015)The past decade has seen a rapid increase in the ability of biologists to collect large amounts of data. It is therefore vital that research biologists acquire the necessary skills during their training to visualize, ... -
Quantitative Methods for Analyzing Structure in Genomes, Self-Assembly, and Random Matrices
(2016-05-20)This dissertation presents my graduate work analyzing biological structure. My research spans three different areas, which I discuss in turn. First I present my work studying how the genome folds. The three-dimensional ... -
Quantitative Methods for Molecular Diagnostic and Therapeutic Imaging
(Ivyspring International Publisher, 2013)This theme issue provides an overview on the basic quantitative methods, an in-depth discussion on the cutting-edge quantitative analysis approaches as well as their applications for both static and dynamic molecular ... -
Quantitative Methods for Stratified Medicine
(2015-05-15)Stratified medicine has tremendous potential to deliver more effective therapeutic intervention to improve public health. For practical implementation, reliable prediction models and clinically meaningful categorization ... -
Quantitative Molecular Assessment of Chimerism across Tissues in Marmosets and Tamarins
(BioMed Central, 2012)Background: Marmosets are playing an increasingly large and important role in biomedical research. They share genetic, anatomical, and physiological similarities with humans and other primate model species, but their smaller ... -
Quantitative Morphological Signatures Define Local Signaling Networks Regulating Cell Morphology
(American Association for the Advancement of Science, 2007)Although classical genetic and biochemical approaches have identified hundreds of proteins that function in the dynamic remodeling of cell shape in response to upstream signals, there is currently little systems-level ... -
A quantitative MR measure of the fornix in schizophrenia
(Elsevier BV, 2001)Some cognitive disturbances accompanying schizophrenia may be due to abnormalities in the thalamus and components of the limbic system. The fornix is an important white-matter relay pathway connecting these structures and ...