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Now showing items 56838-56857 of 56882
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Zinc-induced Alzheimer's Aβ1–40 Aggregation Is Mediated by Conformational Factors
(American Society for Biochemistry & Molecular Biology (ASBMB), 1997-10-17)The heterogeneous precipitates of Aβ that accumulate in the brain cortex in Alzheimer's disease possess varying degrees of resistance to resolubilization. We previously found that Aβ1–40 is rapidly precipitated in vitro ... -
Zipf's Law and the Growth of Cities
(American Economic Association, 1999-05) -
ZNF335: A Novel Regulator of Stem Cell Proliferation and Cell Fate in the Cerebral Cortex
(2013-03-18)Though development of the cerebral cortex is of singular importance to human cognition, it remains very poorly understood. Microcephaly, or "small head," is a neurodevelopmental disorder causing significantly reduced ... -
Zodiacal Exoplanets in Time (Zeit) Iii: A Short-Period Planet Orbiting a Pre-Main-Sequence Star in the Upper Scorpius Ob Association
(American Astronomical Society, 2016)We confirm and characterize a close-in (Porb = 5.425 days), super-Neptune sized (5.04+0.34 −0.37 R⊕) planet transiting K2-33 (2MASS J16101473-1919095), a late-type (M3) pre-main sequence (11 Myr-old) star in the Upper ... -
Zoledronic Acid Enhances Lipopolysaccharide-Stimulated Proinflammatory Reactions through Controlled Expression of SOCS1 in Macrophages
(Public Library of Science, 2013)Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious side effect of nitrogen-containing bisphosphonate (NBP) use. Many studies have shown that BRONJ is limited to the jawbone and does not occur in the other ... -
Zollinger-Ellison Syndrome Associated with von Recklinghausen Disease: Case Report and Literature Review
(International Scientific Literature, Inc., 2016)Patient: Female, 28 Final Diagnosis: Gastrinoma Symptoms: Vomiting • diarrhea • epigastric soreness • heartburn • nausea • significant weight loss Medication: — Clinical Procedure: Esophagogastroduodenoscopy • blood tests ... -
Zonisamide, Topiramate, and Levetiracetam: Efficacy and Neuropsychological Effects in Alcohol Use Disorders
(Lippincott Williams & Wilkins, 2015)Abstract The anticonvulsant topiramate not only decreases ethanol consumption in alcohol dependence (AD) but also may produce several adverse events including cognitive impairment. Zonisamide is a structurally related ... -
Zoom or Bust?: An Exploration into Remote Work Productivity and Best Practices
(2022-05-23)COVID-19 pushed millions of workers from the office to Zoom. With remote work becoming the new normal, firms and employees alike continue to wonder about the benefits or drawbacks to remote work on overall productivity. ... -
Zooming in on accretion – I. The structure of halo gas
(Oxford University Press (OUP), 2016)We study the properties of gas in and around 1012 M⊙ haloes at z = 2 using a suite of high-resolution cosmological hydrodynamic ‘zoom’ simulations. We quantify the thermal and dynamical structure of these gaseous reservoirs ... -
Zooming in on the Chemistry of Star and Planet Formation
(2023-05-09)The dust- and gas-rich environments of protoplanetary disks provide the raw materials needed for forming planets. The molecular gas and associated chemistry are directly tied to the resulting exoplanet architectures, ... -
Zooming in on the progenitors of superluminous supernovae with the HST
(IOP Publishing, 2015)We present Hubble Space Telescope (HST) rest-frame ultraviolet imaging of the host galaxies of 16 hydrogen-poor superluminous supernovae (SLSNe), including 11 events from the Pan-STARRS Medium Deep Survey. Taking advantage ... -
Zooming into earthquake ruptures: from kinematics to dynamic
(2022-01-14)Earthquakes, especially the large ones, cause huge hazards and threaten people living nearby. It is important to improve our understanding of the earthquake source process. I do so by combining seismic data, observations, ... -
Zoroastrian Responses to the Problem of Evil: Seven Approaches Discussing Dualism and Monotheism
(2023)“Is Zoroastrianism Dualist or Monotheistic?” is an article in which Boyd and Crosby present two dualist and four monotheist responses to that question. The authors submit these six versions to philosophical scrutiny according ... -
Zoroastrianism in Armenia
(Harvard University, Department of Near Eastern Languages and Civilizations and National Association for Armenian Studies and Research, 1987) -
ZTF-8 Interacts with the 9-1-1 Complex and Is Required for DNA Damage Response and Double-Strand Break Repair in the C. elegans Germline
(Public Library of Science, 2014)Germline mutations in DNA repair genes are linked to tumor progression. Furthermore, failure in either activating a DNA damage checkpoint or repairing programmed meiotic double-strand breaks (DSBs) can impair chromosome ... -
ZZ → l+l−l′+l′− cross-section measurements and search for anomalous triple gauge couplings in 13 TeV pp collisions with the ATLAS detector
(American Physical Society (APS), 2018-02-07)Measurements of ZZ production in the l+l−l′+l′− channel in proton–proton collisions at 13 TeV center-of-mass energy at the Large Hadron Collider are presented. The data corre- spond to 36.1 fb−1 of collisions collected by ... -
α-Actinin-4 Is Essential for Maintaining the Spreading, Motility and Contractility of Fibroblasts
(Public Library of Science, 2010)Background: α-Actinins cross-link actin filaments, with this cross-linking activity regulating the formation of focal adhesions, intracellular tension, and cell migration. Most non-muscle cells such as fibroblasts express ... -
α-Actinin-4 Is Required for Normal Podocyte Adhesion
(American Society for Biochemistry and Molecular Biology, 2007)Mutations in the alpha-actinin-4 gene ACTN4 cause an autosomal dominant human kidney disease. Mice deficient in alpha-actinin-4 develop a recessive phenotype characterized by kidney failure, proteinuria, glomerulosclerosis, ... -
α-Methylacyl-CoA racemase expression and lethal prostate cancer in the Physicians’ Health Study and Health Professionals Follow-up Study
(Wiley, 2012)BACKGROUND a-Methylacyl-CoA racemase (AMACR) is an enzyme that serves as a diagnostic biomarker of prostate cancer in clinical practice. Recent studies suggest that low AMACR expression is associated with biochemical ... -
α-Synuclein Induces Mitochondrial Dysfunction Through Spectrin and the Actin Cytoskeleton
(2018-09-16)Abnormal accumulation of the cytoplasmic protein α-synuclein in vulnerable neurons and glial is a pathological hallmark of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy, collectively termed ...