Now showing items 57300-57319 of 57727

    • Witnessing Community Violence in Residential Neighborhoods: A Mental Health Hazard for Urban Women 

      Clark, Cheryl; Ryan, Louise; Kawachi, Ichiro; Canner, Marina J.; Berkman, Lisa; Wright, Rosalind J. (Springer Verlag, 2008)
      We examined the prevalence and psychological correlates of witnessing community violence among women of low socioeconomic status living in urban neighborhoods in the northeastern United States. Three hundred eighty-six ...
    • Witnessing Violence Toward Siblings: An Understudied but Potent Form of Early Adversity 

      Teicher, Martin Hersch; Vitaliano, Gordana Dragan (Public Library of Science, 2011)
      Research on the consequences of witnessing domestic violence has focused on inter-adult violence and most specifically on violence toward mothers. The potential consequences of witnessing violence to siblings have been ...
    • The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl− co-transporters 

      delos Heros, Paola; Alessi, Dario R.; Gourlay, Robert; Campbell, David G.; Deak, Maria; Macartney, Thomas J.; Kahle, Kristopher T.; Zhang, Jinwei (Portland Press Ltd., 2014)
      Precise homoeostasis of the intracellular concentration of Cl− is achieved via the co-ordinated activities of the Cl− influx and efflux. We demonstrate that the WNK (WNK lysine-deficient protein kinase)-activated SPAK ...
    • WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration 

      Zhu, Wen; Begum, Gulnaz; Pointer, Kelli; Clark, Paul A; Yang, Sung-Sen; Lin, Shih-Hua; Kahle, Kristopher T; Kuo, John S; Sun, Dandan (BioMed Central, 2014)
      Background: The bumetanide (BMT)-sensitive Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) maintains cell volume homeostasis by increasing intracellular K+ and Cl- content via regulatory volume increase (RVI). Expression levels ...
    • WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma 

      Zhukova, Nataliya; Ramaswamy, Vijay; Remke, Marc; Martin, Dianna C; Castelo-Branco, Pedro; Zhang, Cindy H; Fraser, Michael; Tse, Ken; Poon, Raymond; Shih, David JH; Baskin, Berivan; Ray, Peter N; Bouffet, Eric; Dirks, Peter; von Bueren, Andre O; Pfaff, Elke; Korshunov, Andrey; Jones, David TW; Northcott, Paul A; Kool, Marcel; Pugh, Trevor J; Pomeroy, Scott L; Cho, Yoon-Jae; Pietsch, Torsten; Gessi, Marco; Rutkowski, Stefan; Bognár, Laszlo; Cho, Byung-Kyu; Eberhart, Charles G; Conter, Cecile Faure; Fouladi, Maryam; French, Pim J; Grajkowska, Wieslawa A; Gupta, Nalin; Hauser, Peter; Jabado, Nada; Vasiljevic, Alexandre; Jung, Shin; Kim, Seung-Ki; Klekner, Almos; Kumabe, Toshihiro; Lach, Boleslaw; Leonard, Jeffrey R; Liau, Linda M; Massimi, Luca; Pollack, Ian F; Ra, Young Shin; Rubin, Joshua B; Van Meir, Erwin G; Wang, Kyu-Chang; Weiss, William A; Zitterbart, Karel; Bristow, Robert G; Alman, Benjamin; Hawkins, Cynthia E; Malkin, David; Clifford, Steven C; Pfister, Stefan M; Taylor, Michael D; Tabori, Uri (BioMed Central, 2014)
      TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related radioresistance ...
    • Wnt Secretion from Epithelial Cells and Subepithelial Myofibroblasts Is Not Required in the Mouse Intestinal Stem Cell Niche In Vivo 

      San Roman, Adrianna K.; Jayewickreme, Chenura D.; Murtaugh, L. Charles; Shivdasani, Ramesh A. (Elsevier, 2014)
      Summary Wnt signaling is a crucial aspect of the intestinal stem cell niche required for crypt cell proliferation and differentiation. Paneth cells or subepithelial myofibroblasts are leading candidate sources of the ...
    • Wnt Signaling in Oral Cancer Initiating Cells 

      Menon, Reshma S. (2017-06-12)
      Oral cavity and pharynx cancer is the eighth most common malignancy amongst men in the United States, and more than five times this number are diagnosed on a global scale annually. Owing to the extremely heterogeneous ...
    • Wnt Signaling Mediates Pathological Vascular Growth in Proliferative Retinopathy Clinical Perspective 

      Chen, Jing; Stahl, Andreas; Krah, Nathan M.; Seaward, Molly R.; Dennison, Roberta; Sapieha, Przemyslaw; Hua, Jing; Hatton, Colman J.; Juan, Aimee M.; Aderman, Christopher; Willett, Keirnan L.; Guerin, Karen I.; Mammoto, Akiko; Campbell, Matthew; Smith, Lois Elaine Hodgson (Ovid Technologies (Wolters Kluwer Health), 2011)
      BACKGROUND: Ischemic proliferative retinopathy, characterized by pathological retinal neovascularization, is a major cause of blindness in working-age adults and children. Defining the molecular pathways distinguishing ...
    • Wnt signaling regulates mitochondrial physiology and insulin sensitivity 

      Yoon, John C.; Ng, Aylwin; Kim, Brian H.; Bianco, Antonio; Xavier, Ramnik J.; Elledge, Stephen J. (Cold Spring Harbor Laboratory Press, 2010)
      Mitochondria serve a critical role in physiology and disease. The genetic basis of mitochondrial regulation in mammalian cells has not yet been detailed. We performed a large-scale RNAi screen to systematically identify ...
    • Wnt signaling specifies and patterns intestinal endoderm 

      Sherwood, Richard I.; Maehr, Rene; Mazzoni, Esteban O.; Melton, Douglas A. (Elsevier BV, 2011)
      Wnt signaling has been implicated in many developmental processes, but its role in early endoderm development is not well understood. Wnt signaling is active in posterior endoderm as early as E7.5. Genetic and chemical ...
    • The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML 

      Wang, Yingzi; Krivtsov, Andrei; Sinha, Amit U.; North, Trista Elizabeth; Goessling, Wolfram; Feng, Zhaohui; Zon, Leonard Ira; Armstrong, Scott (American Association for the Advancement of Science (AAAS), 2010)
      Leukemia stem cells (LSCs) are capable of limitless self-renewal and are responsible for the maintenance of leukemia. Because selective eradication of LSCs could offer substantial therapeutic benefit, there is interest in ...
    • Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance 

      Wickström, Malin; Dyberg, Cecilia; Milosevic, Jelena; Einvik, Christer; Calero, Raul; Sveinbjörnsson, Baldur; Sandén, Emma; Darabi, Anna; Siesjö, Peter; Kool, Marcel; Kogner, Per; Baryawno, Ninib; Johnsen, John Inge (Nature Pub. Group, 2015)
      The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly overexpressed in cancers and is implicated in the development of chemoresistance. The use of drugs inhibiting MGMT has been hindered by their ...
    • Wnt/β-Catenin Signaling Pathway in Skin Carcinogenesis and Therapy 

      Li, Jing; Ji, Ling; Chen, Jieping; Zhang, Wengeng; Ye, Zhijia (Hindawi Publishing Corporation, 2015)
      Cooperating with other signaling pathways, Wnt signaling controls cell proliferation, morphology, motility, and embryonic development destination and maintains the homeostasis of tissues including skin, blood, intestine, ...
    • WNT3 Is a Biomarker Capable of Predicting the Definitive Endoderm Differentiation Potential of hESCs 

      Jiang, Wei; Zhang, Donghui; Bursac, Nenad; Zhang, Yi (Elsevier, 2013)
      Generation of functional cells from human pluripotent stem cells (PSCs) through in vitro differentiation is a promising approach for drug screening and cell therapy. However, the observed large and unavoidable variation ...
    • The Wnt5a-Ror Signaling Pathway in the Morphogenesis of the Embryo 

      Susman, Michael Wen (2015-07-13)
      Embryonic development is orchestrated by relatively few conserved core developmental signaling pathways that are used reiteratively to grow, specify and shape all tissues in the body into their final functional forms. The ...
    • Wnt5a/Jnk and FGF/Mapk pathways regulate the cellular events shaping the vertebrate limb bud 

      Gros, Jerome; Hu, Jimmy Kuang-Hsien; Vinegoni, Claudio; Feruglio, Paolo Fumene; Weissleder, Ralph; Tabin, Clifford J. (Elsevier (Cell Press), 2010)
      Background: The vertebrate limb is a classical model for understanding patterning of three-dimensional structures during embryonic development Although decades of research have elucidated the tissue and molecular interactions ...
    • Wnts Enhance Neurotrophin-Induced Neuronal Differentiation in Adult Bone-Marrow-Derived Mesenchymal Stem Cells via Canonical and Noncanonical Signaling Pathways 

      Tsai, Hung-Li; Deng, Wing-Ping; Lai, Wen-Fu Thomas; Chiu, Wen-Ta; Yang, Charn-Bing; Tsai, Yu-Hui; Hwang, Shiaw-Min; Renshaw, Perry F. (Public Library of Science, 2014)
      Wnts were previously shown to regulate the neurogenesis of neural stem or progenitor cells. Here, we explored the underlying molecular mechanisms through which Wnt signaling regulates neurotrophins (NTs) in the NT-induced ...
    • Wolbachia infections in natural Anopheles populations affect egg laying and negatively correlate with Plasmodium development 

      Shaw, W. Robert; Marcenac, Perrine; Childs, Lauren M.; Buckee, Caroline O.; Baldini, Francesco; Sawadogo, Simon P.; Dabiré, Roch K.; Diabaté, Abdoulaye; Catteruccia, Flaminia (Nature Publishing Group, 2016)
      The maternally inherited alpha-proteobacterium Wolbachia has been proposed as a tool to block transmission of devastating mosquito-borne infectious diseases like dengue and malaria. Here we study the reproductive manipulations ...
    • Wolves in Sheep's Clothing: SDO Asymmetrically Predicts Perceived Ethnic Victimization Among White and Latino Students Across Three Years 

      Thomsen, L; Green, E. G. T.; Ho, Arnold; Levin, S.; van Laar, C.; Sinclair, S.; Sidanius, James (SAGE Publications, 2009)
      Dominant groups have claimed to be the targets of discrimination on several historical occasions during violent intergroup conflict and genocide. The authors argue that perceptions of ethnic victimization among members of ...
    • Woman in the Tower: “Nineteen Old Poems” and the Poetics of Un/concealment 

      Tian, Xiaofei (Maney Publishing, 2009)
      This paper examines a group of anonymous poems thought to date from the second century AD. Ostensibly straightforward and transparent, the poems tantalize the reader with a protean quality, for it is often difficult to ...