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Now showing items 8340-8359 of 56883
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Coluccio Salutati e Leonardo Bruni
(Treccani, 2013-01-11) -
The Columbian Exchange: A History of Disease, Food, and Ideas
(American Economic Association, 2010)This paper provides an overview of the long-term impacts of the Columbian Exchange -- that is, the exchange of diseases, ideas, food crops, technologies, populations, and cultures between the New World and the Old World ... -
Columbus in chains: Tennyson and the conquests of monologue
(Harvard Library, 1994) -
Columnar Cell Lesions and Subsequent Breast Cancer Risk: A Nested Case-Control Study
(BioMed Central, 2010)Introduction: Histologic and genetic evidence suggests that at least some columnar cell lesions (CCL) of the breast represent precursor lesions in the low-grade breast neoplasia pathway. However, the risk of subsequent ... -
Columnar-lined esophagus in Chinese patients with proximal gastric carcinomas
(Wiley-Blackwell, 2012)Objective: To investigate the clinicopathological features of columnar-lined esophagus (CLE) in Chinese patients. Methods: Among 182 consecutive resections of proximal gastric cancer with residual esophageal tissue, 114 ... -
Combating Child Obesity in America
(2006)This paper examines the child obesity epidemic that is gripping our nation, and explores various causes and treatments that may help to defeat child obesity. First there is a description of the obesity epidemic, its causal ... -
Combating Depression: A History and Analysis of FDA Regulation of Selective Serotonin Reuptake Inhibitors
(2004)This paper explores historical and current regulation by the Food and Drug Administration (FDA) of the most widely-used class of antidepressant drugs, selective serotonin reuptake inhibitors (SSRIs). To begin, I discuss ... -
Combating Infertility: Machine Learning for Clinical Decision Support
(2022-06-03)One in eight couples is affected by infertility in the United States. In vitro fertilization (IVF) is the most popular treatment option. Unfortunately, the process is time-consuming (1-2 months), costly (\$12,000-15,000), ... -
Combating Non-Communicable Diseases Worldwide: What Role for Drug Research & Development?
(2018-04-27)The share of non-communicable diseases (NCDs) is rising disproportionately fast in low-income and middle-income countries (LMIC) compared to high-income countries (HIC). At the same time, drug Research & Development (R&D) ... -
Combating Social Loafing Performance Reductions in Virtual Groups With Increased Cohesion, Reduced Deindividuation, and Heightened Evaluation Potential Through Self-Disclosure.
(2015-11-10)Over 100 years of research have shown that social loafing is a real and material psychological phenomenon that reduces performance among humans in groups. It is known that increasing evaluation potential, decreasing ... -
Combating transnational crime: The role of learning and norm diffusion in the current rule of law wave
(Cambridge University Press, 2018-01-24) -
"Combating" Trafficking in Persons: An Examination of the Role of the United States in Qatar's Exploitative Guestworker Program
(2022-09-30)Contemporary scholarship contends that guestworker programs are structurally exploitative enabling labor trafficking of vulnerable migrant communities. Such programs are common throughout the globe, though none are as ... -
Combative Pasts: Politics and Remembering in the Post-Communist Space
(2014-02-25)More than two decades after the Polish Roundtable Agreement inaugurated the collapse of the Soviet Bloc, political conversations in the post-communist space remain remarkably attuned to symbolic and ethical questions. ... -
Combatting Substandard and Falsified Medicines: A View from Rwanda
(Public Library of Science, 2013)Agnes Binagwaho and colleagues describe Rwanda's experience of pharmacovigilance for malaria and tuberculosis, and call for a global treaty and leadership by the World Health Organization to address the global manufacture ... -
Combination Antibiotic-Focused Machine Learning Models for Integration into Experimental Workflows
(2022-06-02)Antibiotic resistance is a growing crisis with far-reaching impacts on public and global health [1][2]. With antibiotic resistance impeding the efficacy of antibiotics and the discovery of new antibiotics slowing [2], ... -
Combination immunotherapy: Where do we go from here?
(BioMed Central, 2015)The remarkable clinical success of cancer immunotherapies targeting the checkpoint receptors CTLA-4 and PD-1 has generated considerable excitement and emboldened efforts to build on this important foundation. Research ... -
Combination inhibition of PI3K and mTORC1 yields durable remissions in orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases
(2016)Brain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthotopic patient-derived xenografts (PDXs) of HER2-expressing breast cancer brain metastases ... -
Combination Low-Dose Tissue-Type Plasminogen Activator Plus Annexin A2 for Improving Thrombolytic Stroke Therapy
(Frontiers Media S.A., 2015)Risk of hemorrhagic transformation, incomplete reperfusion, neurotoxicity, and a short treatment time window comprises major challenges for tissue plasminogen activator (tPA) thrombolytic stroke therapy. Improving tPA ... -
Combination of a Novel HDAC 6 Inhibitor ACY-241 with Anti-PD-L1 Antibody Enhances Anti-Tumor Immunity and Cytotoxicity in Multiple Myeloma
(American Society of Hematology, 2016-12-02)Introduction Histone deacetylases (HDACs) are attractive therapeutic targets, and selective HDAC inhibitors (HDACi), alone or in combination with other anti-cancer agents are useful treatment strategies in multiple myeloma ... -
Combination of a Selective HSP90α/β Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells
(Public Library of Science, 2015)Heat shock protein (HSP)90 inhibitors have shown significant anti-tumor activities in preclinical settings in both solid and hematological tumors. We previously reported that the novel, orally available HSP90α/β inhibitor ...