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Now showing items 8342-8361 of 56735
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Combination of the Searches for Pair-Produced Vectorlike Partners of the Third-Generation Quarks at s=13 TeV with the ATLAS Detector
(American Physical Society (APS), 2018-11-20)A combination of the searches for pair-produced vectorlike partners of the top and bottom quarks in various decay channels (T → Zt=Wb=Ht, B → Zb=Wt=Hb) is performed using 36.1 fb−1 of pp collision data at s 1⁄4 13 TeV with ... -
Combination of vinblastine and oncolytic herpes simplex virus vector expressing IL-12 therapy increases antitumor and antiangiogenic effects in prostate cancer models
(2013)Oncolytic herpes simplex virus-1 (oHSV)–based vectors selectively replicate in tumor cells causing direct killing, ie., oncolysis, while sparing normal cells. oHSV’sare promising anticancer agents, but their efficacy, when ... -
Combination Proximal Pulmonary Artery Coiling and Distal Embolization Induces Chronic Elevations in Pulmonary Artery Pressure in Swine
(Public Library of Science, 2015)Pulmonary hypertension (PH) is associated with aberrant vascular remodeling and right ventricular (RV) dysfunction that contribute to early mortality. Large animal models that recapitulate human PH are essential for ... -
A combination SMS and transportation reimbursement intervention to improve HIV care following abnormal CD4 test results in rural Uganda: a prospective observational cohort study
(BioMed Central, 2015)Background: Up to 50 % of HIV-infected persons in sub-Saharan Africa are lost from care between HIV diagnosis and antiretroviral therapy (ART) initiation. Structural barriers, including cost of transportation to clinic and ... -
Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of β-thalassemia intermedia
(BlackWell Publishing Ltd, 2015)β-thalassemias result from diminished β-globin synthesis and are associated with ineffective erythropoiesis and secondary iron overload caused by inappropriately low levels of the iron regulatory hormone hepcidin. The ... -
Combination Therapy with Normobaric Oxygen (NBO) Plus Thrombolysis in Experimental Ischemic Stroke
(BioMed Central, 2009)Background: The widespread use of tissue plasminogen activator (tPA), the only FDA-approved acute stroke treatment, remains limited by its narrow therapeutic time window and related risks of brain hemorrhage. Normobaric ... -
Combination Therapy: Histone Deacetylase Inhibitors and Platinum-Based Chemotherapeutics for Cancer
(Elsevier BV, 2013)One of the most promising strategies to increase the efficacy of standard chemotherapy drugs is by combining them with low doses of histone deacetylases inhibitors (HDACis). Regarded as chemosensitizers, the addition of ... -
A combinational therapy of EGFR-CAR NK cells and oncolytic herpes simplex virus 1 for breast cancer brain metastases
(Impact Journals LLC, 2016)Breast cancer brain metastases (BCBMs) are common in patients with metastatic breast cancer and indicate a poor prognosis. These tumors are especially resistant to currently available treatments due to multiple factors. ... -
Combinations of PARP Inhibitors with Temozolomide Drive PARP1 Trapping and Apoptosis in Ewing’s Sarcoma
(Public Library of Science, 2015)Ewing’s sarcoma is a malignant pediatric bone tumor with a poor prognosis for patients with metastatic or recurrent disease. Ewing’s sarcoma cells are acutely hypersensitive to poly (ADP-ribose) polymerase (PARP) inhibition ... -
Combinatorial Agency of Threshold Functions
(Association for Computing Machinery, 2011)In this paper, we study the combinatorial agency problem introduced by Babaioff, Feldman and Nisan and resolve some open questions posed in their original paper. Our results include a characterization of the transition ... -
A Combinatorial Auction for Collaborative Planning
(Institute of Electrical and Electronics Engineers (IEEE), 2000)When rational, utility-maximizing agents encounter an opportunity to collaborate on a group activity they must determine whether to commit to that activity. We refer to this problem as the initial-commitment decision problem ... -
A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells
(Nature Publishing Group, 2014)Development of three dimensional (3D) microenvironments that direct stem cell differentiation into functional cell types remains a major challenge in the field of regenerative medicine. Here, we describe a new platform to ... -
Combinatorial Complexity and Compositional Drift in Protein Interaction Networks
(Public Library of Science, 2012)The assembly of molecular machines and transient signaling complexes does not typically occur under circumstances in which the appropriate proteins are isolated from all others present in the cell. Rather, assembly must ... -
Combinatorial computational method gives new picomolar ligands for a known enzyme
(National Academy of Sciences, 2002)Combinatorial small molecule growth algorithm was used to design inhibitors for human carbonic anhydrase II. Two enantiomeric candidate molecules were predicted to bind with high potency (with R isomer binding stronger ... -
Combinatorial Diversity of Fission Yeast SCF Ubiquitin Ligases by Homo- and Heterooligomeric Assemblies of the F-Box Proteins Pop1p and Pop2p
(BioMed Central, 2002)Background: SCF ubiquitin ligases share the core subunits cullin 1, SKP1, and HRT1/RBX1/ROC1, which associate with different F-box proteins. F-box proteins bind substrates following their phosphorylation upon stimulation ... -
Combinatorial DNA Rearrangement Facilitates the Origin of New Genes in Ciliates
(Oxford University Press, 2015)Programmed genome rearrangements in the unicellular eukaryote Oxytricha trifallax produce a transcriptionally active somatic nucleus from a copy of its germline nucleus during development. This process eliminates noncoding ... -
A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis
(2013)Extracellular matrix interactions play essential roles in normal physiology and many pathological processes. While the importance of ECM interactions in metastasis is well documented, systematic approaches to identify their ... -
Combinatorial Pathway Modulation Toward Ex Vivo Maintenance and Propagation of Hematopoietic Stem Cells
(2016-05-18)Hematopoietic stem cells (HSCs) sustain continuous turnover and maintenance of all blood lineages through organismal lifespan. The extensive regenerative potential of HSCs has been harnessed in transplantation medicine ... -
Combinatorial Recruitment of CREB, C/EBPβ and c-Jun Determines Activation of Promoters upon Keratinocyte Differentiation
(Public Library of Science, 2013)Background: Transcription factors CREB, C/EBPβ and Jun regulate genes involved in keratinocyte proliferation and differentiation. We questioned if specific combinations of CREB, C/EBPβ and c-Jun bound to promoters correlate ... -
A combinatorial strategy for treating KRAS mutant lung cancer
(2016)Therapeutic targeting of KRAS-mutant lung adenocarcinoma represents a major goal of clinical oncology. KRAS itself has proven difficult to inhibit, and the effectiveness of agents that target key KRAS effectors has been ...