Browsing by Title
Now showing items 8391-8410 of 56883
-
Combined associations of body weight and lifestyle factors with all cause and cause specific mortality in men and women: prospective cohort study
(BMJ Publishing Group, 2016)OBJECTIVE To evaluate the combined associations of diet, physical activity, moderate alcohol consumption, and smoking with body weight on risk of all cause and cause specific mortality. DESIGN Longitudinal study with up ... -
Combined BRAFV600E- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer
(Impact Journals LLC, 2014)Anaplastic (ATC) and refractory papillary thyroid cancer (PTC) lack effective treatments. Inhibition of either oncogenic BRAF or SRC has marked anti-tumor effects in mouse models of thyroid cancer, however, neither drug ... -
Combined Effect of Histone Acetylation and Acetyl Mark Readers on Radiation Sensitivity
(2016-05-17)We are interested in studying potential drugs that have the ability to make tumors more sensitive to radiation. There has been much interest in examining the effect of modulation to chromatin structure on the DNA damage ... -
A Combined Finite Element-Multiple Criteria Optimization Approach for Materials Selection of Gas Turbine Components
(ASME International, 2012)The design of critical components for aerospace applications involves a number of conflicting functional requirements: reducing fuel consumption, cost, and weight, while enhancing performance, operability and robustness. ... -
A combined fMRI and DTI examination of functional language lateralization and arcuate fasciculus structure: Effects of degree versus direction of hand preference
(Elsevier BV, 2010)The present study examined the relationship between hand preference degree and direction, functional language lateralization in Broca’s and Wernicke’s areas, and structural measures of the arcuate fasciculus. Results ... -
Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study
(BioMed Central, 2014)Background: Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The ... -
Combined impact of lifestyle factors on mortality: prospective cohort study in US women
(BMJ Publishing Group Ltd., 2008)Objective: To evaluate the impact of combinations of lifestyle factors on mortality in middle aged women. Design: Prospective cohort study. Setting: Nurses’ health study, United States. Participants: 77 782 women aged 34 ... -
The Combined Influence of Multiple Sex and Growth Hormones on Risk of Postmenopausal Breast Cancer: A Nested Case-control Study
(BioMed Central, 2011)Introduction: Sex and growth hormones are positively associated with postmenopausal breast cancer risk. However, few studies have evaluated the influence of multiple hormones simultaneously. Methods: We considered the roles ... -
Combined Influence of Soil Moisture and Atmospheric Evaporative Demand Is Important for Accurately Predicting US Maize Yields
(Springer Science and Business Media LLC, 2020-02-18)Understanding the response of agriculture to heat and moisture stress is essential to adapt food systems under climate change. Although evidence of crop yield loss with extreme temperature is abundant, disentangling the ... -
Combined inhibition of MEK and Plk1 has synergistic anti-tumor activity in NRAS mutant melanoma
(2015)About one third of cancers harbor activating mutations in rat sarcoma viral oncogene homolog (RAS) oncogenes. In melanoma, aberrant neuroblastoma-RAS (NRAS) signaling fuels tumor progression in about 20% of patients. Current ... -
Combined Lacrimal Passage Probing and Tobramycin/Dexamethasone Ophthalmic Ointment Infiltration: A Minimally Invasive Surgical Procedure for Incomplete Nasolacrimal Duct Obstruction
(Wolters Kluwer Health, 2015)Abstract The optimal treatment strategy for an incomplete nasolacrimal duct obstruction (INDO) is still being debated. The aim of this study is to evaluate the treatment results of combined lacrimal passage probing and ... -
Combined Lymphedema and Capillary Malformation of the Lower Extremity
(Wolters Kluwer Health, 2016)Background: Primary lymphedema and capillary malformation are independent vascular malformations that can cause overgrowth of the lower extremity. We report a series of patients who had both types of malformations affecting ... -
Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer
(American Association for Cancer Research, 2015)Purpose: Improved therapeutic approaches are needed for the treatment of pancreatic ductal adenocarcinoma (PDAC). As dual MEK and PI3K inhibition is presently being used in clinical trials for patients with PDAC, we sought ... -
Combined Micro-Fourier Transform Infrared (FTIR) Spectroscopy and Micro-Raman Spectroscopy of Proterozoic Acritarchs: A New Approach to Palaeobiology
(Elsevier, 2005)Micro-scale analytical techniques permit correlation of chemistry with morphology of individual Proterozoic acritarchs (organic-walled microfossils), and thus provide new approaches for elucidating their biological affinities. ... -
Combined obliquity and precession pacing of the late Pleistocene glacial cycles
(Nature Publishing Group, 2011)Milankovitch1 proposed that Earth resides in an interglacial state when its spin axis both tilts to a high obliquity and precesses to align the Northern Hemisphere summer with Earth’s nearest approach to the Sun. This ... -
Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma: safety run-in and biomarker cohorts of COMBI-i
(Springer Science and Business Media LLC, 2020-10)Checkpoint inhibitors and targeted therapies lead to long-term survival in metastatic melanoma, but many patients still experience progression, and novel treatment strategies are needed.1,2 We report efficacy, safety, and ... -
Combined PET/MR: The Real Work Has Just Started. Summary Report of the Third International Workshop on PET/MR Imaging; February 17–21, 2014, Tübingen, Germany
(Springer US, 2015)This paper summarises the proceedings and discussions at the third annual workshop held in Tübingen, Germany, dedicated to the advancement of the technical, scientific and clinical applications of combined PET/MRI systems ... -
A combined reference panel from the 1000 Genomes and UK10K projects improved rare variant imputation in European and Chinese samples
(Nature Publishing Group, 2016)Imputation using the 1000 Genomes haplotype reference panel has been widely adapted to estimate genotypes in genome wide association studies. To evaluate imputation quality with a relatively larger reference panel and a ... -
Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation
(American Diabetes Association, 2011)OBJECTIVE Recent advances in human islet transplantation are hampered by significant graft loss shortly after transplantation and inability to follow islet fate directly. Both issues were addressed by utilizing a dual-purpose ... -
Combined structural, biochemical and cellular evidence demonstrates that both FGDF motifs in alphavirus nsP3 are required for efficient replication
(The Royal Society, 2016)Recent findings have highlighted the role of the Old World alphavirus non-structural protein 3 (nsP3) as a host defence modulator that functions by disrupting stress granules, subcellular phase-dense RNA/protein structures ...