Browsing by FAS Department "Bioengineering & Nanotechnology"
Now showing items 1-9 of 9
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A Comprehensive Guide for Cell Type-Specific Transduction in Skin Using Adeno-Associated Virus as Delivery Vector
(2020-10-29)The hair follicle cycles between growth, regression, and rest phases. This cyclic activity is regulated by the activation and quiescence of hair follicle stem cells (HFSCs). Recent studies indicate that the crosstalk ... -
A Nano-Biosensor for Label-Free Detection of Nucleic Acid Using Silicon Nano-Structured Materials
(2020-02-25)The development of biosensors for the detection of biological molecules has been subject to an intensive research. Nucleic acid detection of both deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) has been the most ... -
A Novel Chemotherapeutic Nanoparticle Drug Delivery System: Surface Functionalization of Polymeric Nanoparticles With Protein-Phobic Ionic Liquid to Enhance Drug Bioavailability in Systemic Circulation
(2020-02-11)While nanoparticles provide an innovative solution for targeting various diseases, including cancer and neurodegenerative disorders, rapid clearance of nanoparticles from circulation after intravenous injection is a major ... -
Commensals Modulate Innate Immune Response Through L-Plastin to Bacterial Keratitis
(2019-10-09)L-plastin (LPL) is implicated in regulating innate and adaptive immune responses. Previous work showed that the ocular surface proteomes of Specific Pathogen Free mice had high levels of LPL and neutrophil secreted peptides ... -
Design of a Microfluidic Chip to Investigate the Potential Use of Antigen-Driven Voltage Potential Differentials Detected by Silicon Nanowires Capped With Gold Nanoparticles Further Coated With Antibody-Functionalized Dendrimers for Post-Diagnosis of Viral and Bacterial Symptomatic Epilepsy
(2020-09-28)It is no surprise that the advent of Artificial Intelligence (AI) is pushing waves across the medical field, amongst others. With the ability to process data in a more robust and efficient manner, mistakes, usually due to ... -
Elucidation of CYP Inducibility and Inflammatory Response via Cytokine Release in Non-Alcoholic Fatty Liver Disease
(2020-04-14)Non-alcoholic fatty liver disease (NAFLD) is an emerging global health issue that has recently reached 20% in global prevalence and is projected to be the main cause of liver morbidity in the next decade. The lack of ... -
Enhanced Stem Cell Repair of Nervous Tissue: Feasibility of a PLGA Microsphere SDF-1 Dosing Transdermal Microneedle Patch
(2020-09-29)Here is evaluated a strategy for stem cell repair of nervous tissue with a potential therapeutic application of a transdermal microneedle stromal-derived-factor 1 (SDF-1) chemokine delivery system. The central question of ... -
Intracellular Protein Scaffolds Enable Simultaneous Measurement of Multiple Biological Signals From Spectrally Identical Fluorescent Sensors
(2020-02-25)Biological signals interact in complex ways within cells, and can exhibit great cell-to-cell heterogeneity as a function of cell history and state. Therefore, there is increasing desire to use multiple fluorescent sensors ... -
Targeted PLGA Nanoparticles for the Sustained Release of Hypertensive Drugs
(2019-05-07)The focus of this study was to create a PLGA-PEG copolymer nanoparticle (NP), encapsulating the anti-hypertensive drugs valsartan and captopril. The surface of the NP was modified with an anti-ICAM antibody to allow for ...