Browsing by FAS Department "Biology"
Now showing items 1-20 of 40
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A Comparative Analysis Between Three Spatio-Temporal Scan Statistics for Outbreak Detection and Antimicrobial Resistance
(2020-04-27)Antimicrobial resistance is a growing problem throughout the world. Government agencies and other global health organizations have created software for tracking emerging microbial threats on a facility, state-wide and ... -
A Deeper Look at the Unsupervised Learning of Disentangled Representations in β-VAE From the Perspective of Core Object Recognition
(2020-04-04)The ability to recognize objects despite there being differences in appearance, known as Core Object Recognition, forms a critical part of human perception. While it is understood that the brain accomplishes Core Object ... -
A Preliminary study in Propolis (Fungi, Ascomycota): Propolis farinosa - common, cosmopolitan and plurivorous
(2019-08-07)Propolis farinosa, a member of Ascomycota, is a commonly encountered microfungus in temperate and boreal forests of North America and Western Europe. Southern Hemisphere collections are reported from Chile, Australia and ... -
An Investigation of the Gut Microbiota, Microglia, and Peripheral Immunity in the Sod1 Animal Model of ALS
(2020-04-24)Amyotrophic lateral sclerosis is a devastating and debilitating disease as patients maintain cognitive abilities while losing motor function before dying, often from respiratory muscle paralysis within three to five years ... -
Cell Broadcast Alerts as Tools for Community Outreach in Ebola Virus Disease Outbreaks in Central and Western Africa
(2020-09-28)Ebola Virus Disease outbreaks have been a deadly and ongoing problem since the initial outbreaks of Zaire ebolavirus and Sudan ebolavirus in 1976. To date, 28 distinct outbreaks have been identified (CDC, 2017), with the ... -
Central Nervous System Immediate Early Gene Expression Patterns in Zebrafish Models of Epilepsy
(2019-05-10)Zebrafish are a powerful model for studying neurodevelopmental disease, and more recently epilepsy. The characteristics of seizures in zebrafish have until now included largely descriptive abnormalities in swim patterns ... -
Characterizing the Programmatic Response to the Small Molecule Inhibitor, Halofuginol, in a TGFB-Induced Fibroblast
(2019-03-27)The use of small molecule tRNA-synthetase inhibitors has garnered attention for their ability to act as therapeutics for a variety of diseases. Halofuginone and its less toxic analog, Halofuginol, are tRNA-synthetase ... -
Combination Immunotherapy for Glioblastoma Multiforme With the Combination of GVAX and PD-1 Blockade, Using Anti-PD1 Antibody
(2018-05-16)Glioblastoma Multiforme (GBM), also known as grade IV astrocytoma, is generally found in the cerebral hemispheres but can be found anywhere else in the brain or the spinal cord. Even after surgery and chemotherapy, GBM has ... -
Community Engagement and CRISPR Gene Editing for Ecological Intervention in a Shared Ecosystem to Combat Lyme Disease on Martha’s Vineyard
(2019-11-25)Evaluative research on community engagement and the use of CRISPR genome editing for ecosystem engineering has been underappreciated and therefore lacking. This thesis fully describes and evaluates the innovative approach ... -
Comparing General Health Status and the Risk of Comorbid Autoimmune Diseases Between Sleep Apnea and Narcolepsy Patients
(2020-09-22)Background — Sleep disorders such as narcolepsy and sleep apnea are known to cause significant health problems if left untreated. The disorders are quite similar in terms of symptoms, but greatly differ in their etiology ... -
Determining the Relationship Between Male Waist Circumference and Male Fertility Markers
(2020-06-02)Rates of obesity and overweight have been increasing in developing nations for decades and at the same time infertility rates have also been climbing. In the United States obesity among men above 20 years of age has more ... -
Developing an in Vivo Based CRISPR-Induced Genetic Screen to Identify Novel Regulators of T-Cell Dysfunction in the Context of Tumors
(2018-06-01)T-cell dysfunction is a central characteristic of the immune system's response to cancer, and one of the primary mechanisms that allows tumors to escape the immune response and thrive. Within the last decade, there has ... -
Development of a Set of Standardized Toehold Switch Riboregulators and Fluorescent Reporter Proteins for Genetic Circuit Prototyping.
(2020-09-28)The goal of this research was the creation and characterization of a new library of Type IIS standardized biological parts that can be used to construct expression devices for reporter proteins with precise and reliable ... -
Development of a Small Molecule Inhibitor of Interleukin-18 for the Prevention of Vein Graft Failure or Other Inflammatory Diseases
(2018-10-02)Overexpression of Interleukin-18 (IL18), a pleiotropic pro-inflammatory cytokine has been implicated in the early pathogenesis of intimal hyperplasia (IH), the leading cause of delayed graft failure. IL18 Binding Protein ... -
Developmental Postnatal Neuroplasticity of the Primate Amygdala: a Quantitative Analysis of Parvalbumin Neurons and Perineuronal Nets
(2018-11-10)Neuroplasticity is implicated in the pathology of many psychiatric disorders, abnormal behaviors, and learning disabilities. Additionally, abnormalities in neuronal densities and regional volumes have been reported in ... -
Differences in Inflammatory Breast Cancer Characteristics and Outcomes Between Caucasian and Hispanic Women in the US
(2018-09-26)Mortality from breast cancer has declined over time in the US, but breast cancer remains the second leading cause of cancer death among women overall and the leading cause of cancer death among Hispanic women. In the US, ... -
Dynamics of Ubiquitin-Conjugate Population in Response to Inhibition of Ubiquitin-Proteasome Pathway
(2018-06-28)The goal of this research was to evaluate the dynamics of ubiquitin-protein conjugate populations in response to treatment with inhibitors of the ubiquitin-proteasome pathway. The 26S proteasome is a large multimolecular ... -
Endoscopic Ultrasound-Guided Gallbladder Drainage With Lumen-Apposing Metal Stents in Comparison to Percutaneous Cholecystostomy for the Non-Surgical Management of Acute Cholecystitis: Systematic Review and Meta-Analysis
(2018-11-04)Gallstone disease is a widespread medical condition that is associated with high morbidity rates, and often requires surgical intervention (Schirmer, Winters and Edlich). The standard treatment of acute cholecystitis, ... -
In-Vitro Inhibition of P38 Abrogates GITR-Induced Proliferation of Murine iTregs
(2020-07-29)Abstract Triggering the co-stimulatory receptor glucocorticoid-induced TNFR-related protein (GITR) on T cells has been identified as a promising cancer immunotherapy, yet the signaling events by which GITR agonism induces ... -
Inferring High Resolution Transcription Elongation Dynamics from Native Elongating Transcript Sequencing (NET-seq)
(2020-01-23)Regulatory phenomena occur in every phase of eukaryotic transcription. Recent improvements in the measurement of nascent RNA measurements have led to insights in elongation dynamics. Native elongating transcript sequencing ...