Browsing by FAS Department "Biology"
Now showing items 1-17 of 17
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Central Nervous System Immediate Early Gene Expression Patterns in Zebrafish Models of Epilepsy
(2019-05-10)Zebrafish are a powerful model for studying neurodevelopmental disease, and more recently epilepsy. The characteristics of seizures in zebrafish have until now included largely descriptive abnormalities in swim patterns ... -
Characterizing the Programmatic Response to the Small Molecule Inhibitor, Halofuginol, in a TGFB-Induced Fibroblast
(2019-03-27)The use of small molecule tRNA-synthetase inhibitors has garnered attention for their ability to act as therapeutics for a variety of diseases. Halofuginone and its less toxic analog, Halofuginol, are tRNA-synthetase ... -
Combination Immunotherapy for Glioblastoma Multiforme With the Combination of GVAX and PD-1 Blockade, Using Anti-PD1 Antibody
(2018-05-16)Glioblastoma Multiforme (GBM), also known as grade IV astrocytoma, is generally found in the cerebral hemispheres but can be found anywhere else in the brain or the spinal cord. Even after surgery and chemotherapy, GBM has ... -
Developing an in Vivo Based CRISPR-Induced Genetic Screen to Identify Novel Regulators of T-Cell Dysfunction in the Context of Tumors
(2018-06-01)T-cell dysfunction is a central characteristic of the immune system's response to cancer, and one of the primary mechanisms that allows tumors to escape the immune response and thrive. Within the last decade, there has ... -
Development of a Small Molecule Inhibitor of Interleukin-18 for the Prevention of Vein Graft Failure or Other Inflammatory Diseases
(2018-10-02)Overexpression of Interleukin-18 (IL18), a pleiotropic pro-inflammatory cytokine has been implicated in the early pathogenesis of intimal hyperplasia (IH), the leading cause of delayed graft failure. IL18 Binding Protein ... -
Developmental Postnatal Neuroplasticity of the Primate Amygdala: a Quantitative Analysis of Parvalbumin Neurons and Perineuronal Nets
(2018-11-10)Neuroplasticity is implicated in the pathology of many psychiatric disorders, abnormal behaviors, and learning disabilities. Additionally, abnormalities in neuronal densities and regional volumes have been reported in ... -
Differences in Inflammatory Breast Cancer Characteristics and Outcomes Between Caucasian and Hispanic Women in the US
(2018-09-26)Mortality from breast cancer has declined over time in the US, but breast cancer remains the second leading cause of cancer death among women overall and the leading cause of cancer death among Hispanic women. In the US, ... -
Dynamics of Ubiquitin-Conjugate Population in Response to Inhibition of Ubiquitin-Proteasome Pathway
(2018-06-28)The goal of this research was to evaluate the dynamics of ubiquitin-protein conjugate populations in response to treatment with inhibitors of the ubiquitin-proteasome pathway. The 26S proteasome is a large multimolecular ... -
Endoscopic Ultrasound-Guided Gallbladder Drainage With Lumen-Apposing Metal Stents in Comparison to Percutaneous Cholecystostomy for the Non-Surgical Management of Acute Cholecystitis: Systematic Review and Meta-Analysis
(2018-11-04)Gallstone disease is a widespread medical condition that is associated with high morbidity rates, and often requires surgical intervention (Schirmer, Winters and Edlich). The standard treatment of acute cholecystitis, ... -
Knockout of the MISO Gene in the Plasmodium Falciparum Vector Anopheles Gambiae Using the CRISPR-Cas9 System
(2018-04-16)In the course of this thesis I have sought to engineer a line of Anopheles gambiae mosquitoes, the primary vector of the African malaria parasite Plasmodium falciparum, with the Mating Induced Stimulator of Oogenesis (MISO) ... -
Population and Projection-Specific Segregation of Fear and Reward in the Hippocampus
(2019-03-28)The ventral hippocampus (vHPC) has the capacity to encode spatial and emotional information. Here, we utilize activity-dependent tagging strategies and provide evidence that the vCA1 recruits two segregated populations of ... -
Pseudomonas Aeruginosa Inducing Nociception Increases Susceptibility to Bacterial Keratitis
(2019-02-07)Understanding nociceptive signaling during Pseudomonas keratitis and its impact on the immune response can prove to be useful for this very painful infection. While the cornea is one of the mostly densely innervated organs ... -
Sovereign Immunity, Intellectual Property, and the Life Sciences: Investigation and Analysis of the Preserving Access to Cost Effective Drugs Act
(2018-11-27)Between 2011 and 2013, significant changes and case law decisions were made regarding United States Patent Law. These changes have added fuel to the criticism and discourse specifically within life sciences patenting. ... -
The Effect of Increased Feeding in Proportion to Density on Sex Ratios in Zebrafish (Danio Rerio)
(2018-12-19)The laboratory zebrafish (Danio rerio) is a biomedical model organism that can be commonly raised at different rearing densities across and within multiple facilities. Previous studies have shown how these rearing differences ... -
The Importance of Health Literacy Programs at the High School Level
(2019-02-25)The purpose of this research was to investigate the effectiveness of a unique health literacy program titled MEDscience and to gain an understanding of the current state of health education and student health literacy in ... -
The Predictive Power of Past Failure: Using Clinically Available Data to Improve Treatment Algorithms
(2018-11-13)Pediatric rheumatology is a small but rapidly evolving specialty within the field of immunology that has been revolutionized by development of a new class of drugs called biologics. Treatment with these specialized agents ... -
Tracking Juvenile Kemp's Ridley Sea Turtles With Stable Isotopes
(2018-11-04)Every fall, juvenile sea turtles become trapped in Cape Cod Bay and strand as the cooling waters lowers their metabolism into a hypothermic state called cold-stunning. Kemp's ridleys are the most endangered sea turtle ...