Browsing by FAS Department "Health Sciences and Technology"
Now showing items 1-18 of 18
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Cell Wall Endopeptidases in Pseudomonas Aeruginosa
(2020-04-30)The bacterial cell wall is essential for viability, and thus represents an attractive target for antibiotic therapy. Although beta-lactams and certain other antibiotics target enzymes involved in cell wall synthesis, ... -
Characterization of the Sirt6 Knockout in Drosophila Melanogaster
(2020-10-22)Parkinson’s disease (PD) is a movement disorder that is characterized by the loss of dopaminergic neurons in the midbrain. It is known that midbrain dopaminergic neurons demonstrate differential vulnerability to Parkinson’s ... -
CRISPR/Cas9 screen for small molecule inhibitors of clonal hematopoiesis of indeterminate potential
(2020-04-30)Clonal hematopoiesis of indeterminate potential (CHIP) is a novel clinical entity, in which distinct somatic mutations occur at a variant allele fraction of at least 2% in the peripheral blood of healthy individuals. While ... -
Dynamic Expression of Primary Cilia Across Diverse Human Cancers
(2019-06-28)Primary cilia are highly conserved organelles that are best known for their role in signal transduction in development. However, their significance in cancer biology is unclear, with some studies reporting that cilia are ... -
Generation of an Isogenic Cell Line Model to Test Novel Treatment Options for TP53-Mutant AML
(2020-04-30)Acute myeloid leukemia (AML) is a clonal malignancy of cellular elements in the myeloid lineage and is characterized by aberrant proliferation of myeloid blasts in the peripheral blood, bone marrow, or both. Despite ... -
Identifying Novel Modulators of MHC I Expression in Merkel Cell Carcinoma Through Genome-Scale Screens
(2020-04-30)Loss of major histocompatibility complex class I (MHC I) is an important mechanism by which cancer cells evade immune surveillance. Decreased MHC I expression has been reported in 16% to 80% of lesions across different ... -
Impact of a Portable Autonomous Exoskeleton on Human Exertional Metrics During Sloped Walking
(2020-04-30)The Biomechatronics group of the MIT Media Lab has developed an autonomous powered exoskeleton capable of providing a significant metabolic benefit to the user when walking on level ground. To gain a better sense of the ... -
Impact of the Cervicovaginal Microbiome on HIV Susceptibility: An Investigation of Mechanisms and Potential Interventions
(2020-04-30)Sub-Saharan Africa has among the highest HIV infection rates in the world, with an estimated 980,000 new HIV infections in 2017 (Sidebé 2018). Since the majority of HIV transmission occurs through heterosexual sex (UNAIDS, ... -
Learning Representations of Multi-Condition Single-Cell Data
(2020-06-24)The recent ability to measure gene expression, protein levels, and more at single-cell resolution is thought to have great potential for elucidating disease mechanisms. This is in part because of the prospect of comparing ... -
Modeling Chemotherapy-Induced Peripheral Neuropathy in a Human Stem Cell Based Model
(2020-04-30)Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting, debilitating, and common side effect of multiple classes of antineoplastic drugs that are used as first-line therapies for cancer. Yet, the mechanisms ... -
Modulating BLA-vHPC Synapses to Reduce Anxiety-Like Behavior in Mice
(2019-06-28)Although anxiety disorders are some of the most prevalent mental health conditions, current pharmacotherapies are often ineffective or associated with negative side effects because the neural mechanisms underlying anxiety ... -
Mouse Models Expresssing Precursors of Broadly Neutralizing Antibodies Against HIV
(2019-06-28)An effective HIV vaccine would undoubtedly be the best solution for controlling the AIDS pandemic. Unfortunately, none of the numerous HIV-1 vaccine development efforts have succeeded to date. The enormous diversity of ... -
Predictive Value of Ventilatory Efficiency Across Categories of Heart Failure
(2019-06-28)Background: In cardiopulmonary stress testing (CPET), minute ventilation-carbon dioxide production relationship (VE/VCO2 slope) strongly predicts outcomes in heart failure (HF). A VE/VCO2 classification system evaluated ... -
Stem Cell Hierarichies within Tumor Genetic Subclones
(2019-06-28)Intratumoral heterogeneity has been appreciated at the genetic and transcriptional levels, yet it remains unclear how they relate to one another. My thesis project applies a novel qPCR technique to combine single-cell ... -
The Effect of Epithelial-Mesenchymal Transition on Ribosomal Protein Heterogeneity in Circulating Tumor Cells
(2020-04-30)Metastasis is the primary cause of morbidity and mortality in cancer patients. During the metastatic progression, a cancer cell must detach from the primary site and intravasate into a blood vessel, survive in circulation, ... -
The Epigenetic Landscape of Intestinal Tumors and the Role of Polycomb Repressive Complex 2
(2020-04-30)Epigenetic mechanisms regulate gene expression programs, and consequently, cell fate specification. DNA methylation, histone modifications, and chromatin structure remodeling represent epigenetic changes that can interact ... -
The Role of GM-CSF in Myocardial Infarction
(2019-06-28)Myocardial infarction (MI) is characterized by an obstruction of blood flow to the myocardium, leading to deprivation of oxygen and eventually, irreversible tissue death. After tissue death, intense inflammation occurs, ... -
Using Intraoperative Optical Coherence Tomography to Image Pediatric Unilateral Vocal Fold Paralysis
(2020-04-30)Purpose: Unilateral vocal fold paralysis (UVFP) impairs communication and reduces academic performance and social interactions in children. Deciding between temporary, permanent, or potentially destructive surgical ...