Browsing by FAS Department "Master’s Program in Clinical Investigation"
Now showing items 1-20 of 48
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5-α REDUCTASE INHIBITORS in TREATMENT of BENIGN PROSTATIC HYPERPLASIA
(2019-05-30)Benign prostatic hyperplasia (BPH) is one of the most commonly diagnosed chronic diseases in older men associated with a gradual deterioration of lower urinary tract symptoms (LUTS). 5-α reductase inhibitors (5ARIs) are ... -
Amygdalar Activity Measured Using FDG-PET/CT at Head and Neck Cancer Staging Independently Predicts Survival and Cardiovascular Outcomes: A Retrospective Cohort Study
(2019-06-03)Background Chronic stress associates with higher mortality among individuals with cancer; however, the mechanisms underlying this association remain incompletely understood. Quantification of amygdalar metabolic activity ... -
Anti-PD-1 Based Immunotherapy in Melanoma: Application of Machine Learning to Predict Survival and Elucidate Complex Relationships
(2018-05-18)Project 1 Background: We assessed if machine learners outperform Cox-PH models in a high dimensional setting in the context of anti-PD-1 treatment for melanoma brain metastases as accurate prediction of overall survival/OS ... -
Application of Machine Learning and Causal Inference Approaches to Bronchiolitis and Asthma Research
(2020-06-02)OVERVIEW: During the curriculum of Master of Medical Sciences Program at Harvard Medical School, I have been focusing on two inferential goals through respiratory disease research—1) prediction and 2) causal inference—which ... -
Cardiac Rehabilitation for Secondary Prevention of Cardiovascular Diseases
(2020-06-02)Outpatient cardiac rehabilitation programs provide supervised exercise training in conjunction with other secondary prevention interventions. They are designed to speed recovery from acute cardiovascular events such as ... -
Cardiovascular Risk and Guideline-Directed Therapy for Risk Reduction Among Young Adults With Myocardial Infarction
(2018-05-18)Background: Despite significant progress in primary prevention, the rate of MI has not declined in young adults. Objectives: We aimed to evaluate statin eligibility based on the 2013 American College of Cardiology / ... -
Characteristics of Very Young Patients Who Experience a Myocardial Infarction: An Opportunity for Enhanced Prevention
(2019-05-30)Aims: We sought to compare the risk factor profiles and outcomes between very young (age ≤40) and young (40< age ≤50) individuals who experienced a first-time MI at a young age. Methods: We evaluated all patients ≤ 50 years ... -
Characterizing Changes in Oral Microbiota With Cardiometabolic Risk Factors
(2020-06-02)Recent evidence has demonstrated association between dysbiosis of oral and gut microbiota with Cardiometabolic risk factors (CMR). However, the nature of dysbiosis and its implication on cardiometabolic risk phenotypes ... -
Clinical Application of Liquid Biopsies for Disease Monitoring and Understanding Therapeutic Resistance in Metastatic Breast Cancer
(2019-05-30)Purpose Biomarkers for early detection of disease progression in MBC are urgently needed. We explored on-treatment increase in ctDNA fraction as an early prognostic biomarker of subsequent disease progression. Methods Eighty ... -
Clinical Presentations and Intraoperative Pathology Strategy in Cushing’s Disease
(2019-06-06)Abstract 1 Background: To define the symptoms, signs and treatment outcomes in a population of older patients with Cushing’s disease (CD). Methods: We analyzed the clinical presentation and treatment outcomes in 45 CD ... -
Comparative Effectiveness Study of Osteoporosis Medications Using Electronic Medical Records
(2019-05-30)Over the last two decades, various drugs have been approved for the treatment of osteoporosis, including alendronate, risedronate, ibandronate, zoledronic acid, estrogen replacement therapy, selective estrogen receptor ... -
CRISPRing Tuberculosis: Potential Application of a CRISPR-Based Technology in the Rapid Detection of Mycobacterium Tuberculosis
(2020-06-02)Tuberculosis (TB) is a deadly infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis). Currently, it is the leading infectious disease killer in the world ranking above HIV/AIDS. Furthermore, the continued ... -
Cross-Reactivity Between Dietary Proteins and Chemicals Bound to Albumin With Thyroid Axis Target Sites
(2018-05-18)The rate of autoimmune diseases is on the rise worldwide. Autoimmune thyroid disease is the most common autoimmune disease. No known cures have been found for autoimmune diseases; however, environmental factors, including ... -
Direct Endoscopic Necrosectomy With Lumen Apposing Metal Stents for Pancreatic Walled Off Necrosis
(2020-06-02)Direct endoscopic necrosectomy (DEN) with lumen-apposing metal stents (LAMS) is increasingly used in the management of pancreatic walled-off necrosis (WON). Early identification of high-risk patients irresponsive to DEN ... -
Effect of Hepatitis C Virus Infection on Outcomes After Kidney Transplantation
(2020-06-02)Hepatitis C Virus (HCV) infection in a donor, recipient, or both affects deceased-donor kidney transplantation outcomes. Direct-acting antivirals (DAA) may influence those outcomes. The Organ Procurement and Transplantation ... -
Emerging Targeted Therapies in the Treatment of Advanced or Metastatic Esophagogastric Cancer (EGC)
(2020-06-02)Esophagogastric cancer (EGC) is the 2nd leading cause of cancer-related death worldwide and have unmet need to explore new treatment options. In first phase II study Heat Shock Protein (HSP 90) inhibitor Ganetespib show ... -
Frailty and Related Outcomes in Patients Undergoing Transcatheter Valve Therapies
(2019-05-30)As the population ages, understanding the relationship between frailty, a syndrome involving multisystem impairment in functional recovery, and outcomes is increasingly important to accurately predict healthcare utilization ... -
Genetic Determinants of Diabetic Neuropathy
(2019-05-30)Paper 1 Genetic factors have been postulated to be involved in the etiology of diabetic peripheral neuropathy (DPN), but their identity remains mostly unknown. The aim of this study was to conduct a systematic search for ... -
High Risk Pregnancy
(2019-05-30)Paper 1: Predictors of antepartum admission in diabetes Objective: Diabetes is associated with increased healthcare utilization and cost in pregnant women. We sought to investigate the predictors of antepartum hospitalization ... -
Impact and Association of Preoperative Oral Health and Dental Screening Approach on 90-Day Mortality After Cardiac Valve Surgery
(2019-05-30)Abstract paper 1- Background: Preoperative dental screening (PDS) prior to valvular surgery has been adopted widely by cardiac surgery to prevent poor outcomes associated with infections of oral origin. However, there is ...