Now showing items 1-20 of 391

    • 3D Axon Structure Extraction and Analysis in Confocal Fluorescence Microscopy Images 

      Zhang, Yong; Zhou, Xiaobo; Lu, Ju; Lichtman, Jeff; Adjeroh, Donald; Wong, Stephen T. C. (Massachusetts Institute of Technology Press, 2008)
      The morphological properties of axons, such as their branching patterns and oriented structures, are of great interest for biologists in the study of the synaptic connectivity of neurons. In these studies, researchers use ...
    • 3D Multicolor Super-Resolution Imaging Offers Improved Accuracy in Neuron Tracing 

      Lakadamyali, Melike; Babcock, Hazen P.; Bates, Mark; Zhuang, Xiaowei; Lichtman, Jeff (Public Library of Science, 2012)
      The connectivity among neurons holds the key to understanding brain function. Mapping neural connectivity in brain circuits requires imaging techniques with high spatial resolution to facilitate neuron tracing and high ...
    • Adaptation at the output of the chemotaxis signalling pathway 

      Yuan, Junhua; Branch, Richard William; Hosu, Basarab Gabriel; Berg, Howard Curtis (2012)
      In the bacterial chemotaxis network, receptor clusters process input1–3, and flagellar motors generate output4. Receptor and motor complexes are coupled by the diffusible protein CheY-P. Receptor output (the steady-state ...
    • Adaptation Kinetics in Bacterial Chemotaxis 

      Block, Steven M.; Segall, Jeffrey E.; Berg, Howard Curtis (American Society for Microbiology, 1983)
      Cells of Escherichia coli, tethered to glass by a single flagellum, were subjected to constant flow of a medium containing the attractant alpha-methyl-DL-aspartate. The concentration of this chemical was varied with a ...
    • Adaptive Locomotor Behavior in Larval Zebrafish 

      Portugues, Ruben; Engert, Florian (Frontiers Media SA, 2011)
      In this study we report that larval zebrafish display adaptive locomotor output that can be driven by unexpected visual feedback. We develop a new assay that addresses visuomotor integration in restrained larval zebrafish. ...
    • Adaptive Remodelling by FliN in the Bacterial Rotary Motor 

      Branch, Richard; Sayegh, Michael; Shen, Chong; Nathan, Vedavalli S.J.; Berg, Howard Curtis (Elsevier BV, 2014)
      Sensory adaptation in the Escherichia coli chemosensory pathway has been the subject of interest for decades, with investigation focusing on the receptors that process extracellular inputs. Recent studies demonstrate that ...
    • Ageing: Generations of longevity 

      Mango, Susan (Nature Publishing Group, 2011)
      The lifespan of some organisms can be extended by mutations that alter how DNA is packaged in their cells. A study reveals that this effect can last for generations, even in descendants that are genetically normal.
    • Agrin and Synaptic Laminin Are Required to Maintain Adult Neuromuscular Junctions 

      Samuel, Melanie Ann; Valdez, Gregorio; Tapia, Juan; Lichtman, Jeff; Sanes, Joshua R. (Public Library of Science, 2012)
      As synapses form and mature the synaptic partners produce organizing molecules that regulate each other’s differentiation and ensure precise apposition of pre- and post-synaptic specializations. At the skeletal neuromuscular ...
    • All β Cells Contribute Equally to Islet Growth and Maintenance 

      Brennand, Kristen; Huangfu, Danwei; Melton, Douglas (Public Library of Science, 2007)
      In healthy adult mice, the β cell population is not maintained by stem cells but instead by the replication of differentiated β cells. It is not known, however, whether all cells contribute equally to growth and maintenance, ...
    • Amplitude and Decay Rate Analysis of Low Level Exponentially Decaying Radio-Frequency Signals 

      Berg, Howard (American Institute of Physics, 1965)
      A method is described which allows routine measurements of the relative amplitudes and absolute decay rates of low level exponentially decaying radio-frequency signals to be made to within an accuracy of 1%. The signals ...
    • Anaerobic Oxidation of Short-Chain Alkanes in Hydrothermal Sediments: Potential Influences on Sulfur Cycling and Microbial Diversity 

      Adams, Melissa Marie; Hoarfrost, Adrienne L.; Bose, Arpita; Joye, Samantha B.; Girguis, Peter R. (Frontiers Research Foundation, 2013)
      Short-chain alkanes play a substantial role in carbon and sulfur cycling at hydrocarbon-rich environments globally, yet few studies have examined the metabolism of ethane \((C_2)\), propane \((C_3)\), and butane \((C_4)\) ...
    • Analysis of 14 BAC Sequences from the Aedes Aegypti Genome: A Benchmark for Genome Annotation and Assembly 

      Lobo, Neil F; Campbell, Kathy S; Thaner, Daniel; deBruyn, Becky; Koo, Hean; Gelbart, William Martin; Loftus, Brendan J; Severson, David W; Collins, Frank H (BioMed Central, 2007)
      In order to provide a set of manually curated and annotated sequences from the Aedes aegypti genome, mapped BAC clones encompassing 1.57 Mb were sequenced, assembled and manually annotated using computational gene-finding, ...
    • Annotation of the Drosophila Melanogaster Euchromatic Genome: A Systematic Review 

      Misra, Sima; Mungall, Christopher J; Campbell, Kathryn S; Hradecky, Pavel; Huang, Yanmei; Kaminker, Joshua S; Millburn, Gillian H; Prochnik, Simon E; Tupy, Jonathan L; Whitfield, Eleanor J; Bayraktaroglu, Leyla; Bettencourt, Brian R; Celniker, Susan E; de Grey, Aubrey DNJ; Drysdale, Rachel A; Harris, Nomi L; Richter, John; Shu, ShengQiang; Stapleton, Mark; Yamada, Chihiro; Ashburner, Michael; Rubin, Gerald M; Lewis, Suzanna E; Crosby, Madeline; Matthews, Beverley; Smith, Christopher D; Berman, Benjamin P; Russo, Susan; Schroeder, Andrew; Gelbart, William Martin (BioMed Central, 2002)
      The recent completion of the Drosophila melanogaster genomic sequence to high quality, and the availability of a greatly expanded set of Drosophila cDNA sequences, afforded FlyBase the opportunity to significantly improve ...
    • Antifungal Chemical Compounds Identified Using a C. elegans Pathogenicity Assay 

      Breger, Julia; Fuchs, Beth Burgwyn; Aperis, George; Moy, Terence I; Ausubel, Frederick M.; Mylonakis, Eleftherios; Cormack, Brendan P (Public Library of Science, 2007)
      There is an urgent need for the development of new antifungal agents. A facile in vivo model that evaluates libraries of chemical compounds could solve some of the main obstacles in current antifungal discovery. We show ...
    • Antigen Processing and Presentation: TAPping into ABC Transporters 

      Procko, Erik; Gaudet, Rachelle (Elsevier, 2009)
      Adaptive, cell-mediated immunity involves the presentation of antigenic peptides on class I MHC molecules at the cell surface. This requires an ABC transporter associated with antigen processing (TAP) to transport antigenic ...
    • Apollo: A Sequence Annotation Editor 

      Lewis, SE; Searle, SMJ; Iyer, V; Wiel, C; Bayraktaroglu, L; Birney, E; Kaminker, JS; Prochnik, SE; Smith, CD; Tupy, JL; Rubin, GM; Mungall, CJ; Clamp, ME; Harris, N; Gibson, M; Richter, J; Crosby, Madeline; Matthews, Beverley; Misra, S (BioMed Central, 2002)
      The well-established inaccuracy of purely computational methods for annotating genome sequences necessitates an interactive tool to allow biological experts to refine these approximations by viewing and independently ...
    • Asymmetric Mutualism in Two- and Three-Dimensional Range Expansions 

      Lavrentovich, Maxim Olegovich; Nelson, David R. (American Physical Society, 2014)
      Genetic drift at the frontiers of two-dimensional range expansions of microorganisms can frustrate local cooperation between different genetic variants, demixing the population into distinct sectors. In a biological context, ...
    • Asymmetry in Sexual Pheromones Is Not Required for Ascomycete Mating 

      Gonçalves-Sá, Joana; Murray, Andrew W. (Elsevier BV, 2011)
      Highlights Asymmetric modification of pheromones is not required for yeast mating Two yeast strains that express complementary pheromones and receptors mate with each other Two yeast strains that express the ...
    • Asymmetry in the Clockwise and Counter-Clockwise Rotation of the Bacterial Flagellar Motor 

      Yuan, Junhua; Fahrner, Karen Alicia; Turner, Linda; Berg, Howard (National Academy of Sciences, 2010)
      Cells of Escherichia coli are able to swim up gradients of chemical attractants by modulating the direction of rotation of their flagellar motors, which spin alternately clockwise (CW) and counterclockwise (CCW). Rotation ...
    • Atomic Layer Deposition to Fine-Tune the Surface Properties and Diameters of Fabricated Nanopores 

      Chen, Peng; Mitsui, Toshiyuki; Farmer, Damon B.; Golovchenko, Jene; Gordon, Roy; Branton, Daniel (American Chemical Society, 2004)
      Atomic layer deposition of alumina enhanced the molecule sensing characteristics of fabricated nanopores by fine-tuning their surface properties, reducing 1/f noise, neutralizing surface charge to favor capture of DNA and ...