Browsing by Keyword "B cells"
Now showing items 1-3 of 3
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CD39 and Control of Cellular Immune Responses
(Springer Verlag, 2007)CD39 is the cell surface-located prototypic member of the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. Biological actions of CD39 are a consequence (at least in part) of the regulated phosphohydrolytic ... -
Circulating Human Neonatal Naïve B Cells are Deficient in CD73 Impairing Purine Salvage
(Frontiers Media S.A., 2016)Background: Extracellular purines, in particular adenosine (Ado) and adenosine-triphosphate, are critical immunoregulatory molecules. Expression and activity of purine ecto-enzymes on B cells in neonatal and adult blood ... -
Efficacy and safety of epratuzumab in patients with moderate/severe active systemic lupus erythematosus: results from EMBLEM, a phase IIb, randomised, double-blind, placebo-controlled, multicentre study
(BMJ Publishing Group, 2014)Objective: To identify a suitable dosing regimen of the CD22-targeted monoclonal antibody epratuzumab in adults with moderately to severely active systemic lupus erythematosus (SLE). Methods: A phase IIb, multicentre, ...