Now showing items 1-19 of 19

    • Anesthetic Sevoflurane Causes Rho-Dependent Filopodial Shortening in Mouse Neurons 

      Zimering, Jeffrey H.; Dong, Yuanlin; Fang, Fang; Huang, Lining; Zhang, Yiying; Xie, Zhongcong (Public Library of Science, 2016)
      Early postnatal anesthesia causes long-lasting learning and memory impairment in rodents, however, evidence for a specific neurotoxic effect on early synaptogenesis has not been demonstrated. Drebrin A is an actin binding ...
    • Automated Screening of Microtubule Growth Dynamics Identifies MARK2 as a Regulator of Leading Edge Microtubules Downstream of Rac1 in Migrating Cells 

      Nishimura, Yukako; Applegate, Kathryn; Davidson, Michael W.; Danuser, Gaudenz; Waterman, Clare M. (Public Library of Science, 2012)
      Polarized microtubule (MT) growth in the leading edge is critical to directed cell migration, and is mediated by Rac1 GTPase. To find downstream targets of Rac1 that affect MT assembly dynamics, we performed an RNAi screen ...
    • Calcium, TRPC channels, and regulation of the actin cytoskeleton in podocytes: towards a future of targeted therapies 

      Wieder, Nicolas; Greka, Anna (Springer Berlin Heidelberg, 2015)
      With more than 6,000 new pediatric patients with treatment-resistant nephrotic syndrome in the US each year alone, the unmet need for novel, podocyte-specific therapies is substantial. Recently, the established therapeutic ...
    • Cell Elasticity Determines Macrophage Function 

      Patel, Naimish R.; Bole, Medhavi; Chen, Cheng; Hardin, Charles Corey; Kho, Alvin Thong-Juak; Mih, Justin; Deng, Linhong; Butler, James Preston; Tschumperlin, Daniel J.; Fredberg, Jeffrey J.; Krishnan, Ramaswamy; Koziel, Henryk (Public Library of Science, 2012)
      Macrophages serve to maintain organ homeostasis in response to challenges from injury, inflammation, malignancy, particulate exposure, or infection. Until now, receptor ligation has been understood as being the central ...
    • Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing 

      Feng, Di; Steinke, Julia M.; Krishnan, Ramaswamy; Birrane, Gabriel; Pollak, Martin R. (Public Library of Science, 2016)
      Genetic testing in the clinic and research lab is becoming more routinely used to identify rare genetic variants. However, attributing these rare variants as the cause of disease in an individual patient remains challenging. ...
    • Gas2l3, a Novel Constriction Site-Associated Protein Whose Regulation Is Mediated by the \(APC/C^{Cdh1}\) Complex 

      Pe’er, Tal; Lahmi, Roxane; Sharaby, Yaara; Chorni, Evelin; Noach, Meirav; Vecsler, Manuela; Zlotorynski, Eitan; Steen, Hanno; Steen, Judith A.; Tzur, Amit (Public Library of Science, 2013)
      Growth arrest-specific 2-like protein 3 (Gas2l3) was recently identified as an Actin/Tubulin cross-linker protein that regulates cytokinesis. Using cell-free systems from both frog eggs and human cells, we show that the ...
    • Growth cone-specific functions of XMAP215 in restricting microtubule dynamics and promoting axonal outgrowth 

      Lowery, Laura Anne; Stout, Alina; Faris, Anna E; Ding, Liya; Baird, Michelle A; Davidson, Michael W; Danuser, Gaudenz; Van Vactor, David (BioMed Central, 2013)
      Background: Microtubule (MT) regulators play essential roles in multiple aspects of neural development. In vitro reconstitution assays have established that the XMAP215/Dis1/TOG family of MT regulators function as MT ...
    • Inter- and Intracellular Effects of Traumatic Axonal Injury 

      Dabiri, Borna Esfahani (2014-06-06)
      Mild Traumatic Brain Injuries (mTBIs) are non-penetrating brain injuries that do not result in gross pathological lesions, yet they may cause a spectrum of cognitive and behavioral deficits. mTBI has been placed in the ...
    • JunB Mediates Basal- and TGFβ1-Induced Smooth Muscle Cell Contractility 

      Ramachandran, Aruna; Gangopadhyay, Samudra Saurabh; Krishnan, Ramaswamy; Ranpura, Sandeep A.; Rajendran, Kavitha; Ram-Mohan, Sumati; Mulone, Michelle; Gong, Edward M.; Adam, Rosalyn Mare (Public Library of Science, 2013)
      Smooth muscle contraction is a dynamic process driven by acto-myosin interactions that are controlled by multiple regulatory proteins. Our studies have shown that members of the AP-1 transcription factor family control ...
    • Lamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development 

      Razafsky, David; Ward, Candace; Potter, Chloe; Zhu, Wanqiu; Xue, Yunlu; Kefalov, Vladimir J.; Fong, Loren G.; Young, Stephen G.; Hodzic, Didier (The American Society for Cell Biology, 2016)
      Lamin B1 and lamin B2 are essential building blocks of the nuclear lamina, a filamentous meshwork lining the nucleoplasmic side of the inner nuclear membrane. Deficiencies in lamin B1 and lamin B2 impair neurodevelopment, ...
    • Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function 

      McCain, Megan L.; Parker, Kevin Kit (Springer Nature, 2011)
      Mechanotransduction refers to the conversion of mechanical forces into biochemical or electrical signals that initiate structural and functional remodeling in cells and tissues. The heart is a kinetic organ whose form ...
    • Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion 

      Saslowsky, David E.; Thiagarajah, Jay R.; McCormick, Beth A.; Lee, Jean C.; Lencer, Wayne I. (The American Society for Cell Biology, 2016)
      The apical brush border membrane (BBM) of intestinal epithelial cells forms a highly structured and dynamic environmental interface that serves to regulate cellular physiology and block invasion by intestinal microbes and ...
    • Molecular requirements for morphogenesis in Plasmodium falciparum, the human malaria parasite 

      Clements, Rebecca Lynn (2021-03-05)
      Malaria, which is caused by Plasmodium parasites, remains a major cause of illness and death worldwide. P. falciparum, the parasite responsible for severe malaria, alters its shape dramatically during development to adapt ...
    • Mutation of Growth Arrest Specific 8 Reveals a Role in Motile Cilia Function and Human Disease 

      Lewis, Wesley R.; Malarkey, Erik B.; Tritschler, Douglas; Bower, Raqual; Pasek, Raymond C.; Porath, Jonathan D.; Birket, Susan E.; Saunier, Sophie; Antignac, Corinne; Knowles, Michael R.; Leigh, Margaret W.; Zariwala, Maimoona A.; Challa, Anil K.; Kesterson, Robert A.; Rowe, Steven M.; Drummond, Iain A.; Parant, John M.; Hildebrandt, Friedhelm; Porter, Mary E.; Yoder, Bradley K.; Berbari, Nicolas F. (Public Library of Science, 2016)
      Ciliopathies are genetic disorders arising from dysfunction of microtubule-based cellular appendages called cilia. Different cilia types possess distinct stereotypic microtubule doublet arrangements with non-motile or ...
    • A Possible Role for Integrin Signaling in Diffuse Axonal Injury 

      Hemphill, Matthew Allen; Dabiri, Borna Esfahani; Gabriele, Sylvain; Kerscher, Lucas; Franck, Christian; Goss, Josue; Alford, Patrick W.; Parker, Kevin Kit (Public Library of Science (PLoS), 2011)
      Over the past decade, investigators have attempted to establish the pathophysiological mechanisms by which non-penetrating injuries damage the brain. Several studies have implicated either membrane poration or ion channel ...
    • Regulation of microtubule-based transport by MAP4 

      Semenova, Irina; Ikeda, Kazuho; Resaul, Karim; Kraikivski, Pavel; Aguiar, Mike; Gygi, Steven; Zaliapin, Ilya; Cowan, Ann; Rodionov, Vladimir (The American Society for Cell Biology, 2014)
      Microtubule (MT)-based transport of organelles driven by the opposing MT motors kinesins and dynein is tightly regulated in cells, but the underlying molecular mechanisms remain largely unknown. Here we tested the regulation ...
    • Self-Organization of Muscle Cell Structure and Function 

      Grosberg, Anna; Kuo, Po-Ling; Guo, Chin-Lin; Geisse, Nicholas A.; Bray, Mark-Anthony; Adams, William J.; Sheehy, Sean Paul; Parker, Kevin Kit (Public Library of Science (PLoS), 2011)
      The organization of muscle is the product of functional adaptation over several length scales spanning from the sarcomere to the muscle bundle. One possible strategy for solving this multiscale coupling problem is to ...
    • The Role and Regulation of FtsZ Filaments in Bacterial Cytokinesis 

      Squyres, Georgia Rae (2020-10-14)
      Like all cells, bacteria must divide in order to proliferate. This process must be carefully controlled in space and time to ensure that these cells maintain the appropriate size, shape, and DNA content, and respond ...
    • Vascular Disrupting Agent Drug Classes Differ in Effects on the Cytoskeleton 

      Kim, Sujeong; Peshkin, Lenoid; Mitchison, Timothy J. (Public Library of Science, 2012)
      Vascular disrupting agents (VDAs), anti-cancer drugs that target established tumor blood vessels, fall into two main classes: microtubule targeting drugs, exemplified by combretastatin A4 (CA4), and flavonoids, exemplified ...