Browsing by Keyword "ERK, extracellular signal-regulated kinase"
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How to unleash mitochondrial apoptotic blockades to kill cancers?
(Elsevier, 2017)Apoptosis, especially the intrinsic mitochondrial cell death pathway, is regulated by the BCL-2 family of proteins. Defects in apoptotic machinery are one of the main mechanisms that cells employ to evade cell death and ... -
Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis★
(Elsevier, 2013)Insulin receptor substrates (Irs1, 2, 3 and Irs4) mediate the actions of insulin/IGF1 signaling. They have similar structure, but distinctly regulate development, growth, and metabolic homeostasis. Irs2 contributes to ...