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    • Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss 

      Scekic‐Zahirovic, Jelena; Sendscheid, Oliver; El Oussini, Hajer; Jambeau, Mélanie; Sun, Ying; Mersmann, Sina; Wagner, Marina; Dieterlé, Stéphane; Sinniger, Jérome; Dirrig‐Grosch, Sylvie; Drenner, Kevin; Birling, Marie‐Christine; Qiu, Jinsong; Zhou, Yu; Li, Hairi; Fu, Xiang‐Dong; Rouaux, Caroline; Shelkovnikova, Tatyana; Witting, Anke; Ludolph, Albert C; Kiefer, Friedemann; Storkebaum, Erik; Lagier‐Tourenne, Clotilde; Dupuis, Luc (John Wiley and Sons Inc., 2016)
      Abstract FUS is an RNA‐binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS‐containing aggregates are often associated with concomitant loss of nuclear FUS. ...