Browsing by Keyword "GSK-3 inhibitor"

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Identification of a Maleimide-Based Glycogen Synthase Kinase-3 (GSK-3) Inhibitor, BIP-135, That Prolongs the Median Survival Time of Δ7 SMA KO Mouse Model of Spinal Muscular Atrophy

Chen, Po C.; Gaisina, Irina N.; El-Khodor, Bassem F.; Ramboz, Sylvie; Makhortova, Nina R; Rubin, Lee; Kozikowski, Alan P. (American Chemical Society (ACS), 2013)

The discovery of upregulated glycogen synthase kinase-3 (GSK-3) in various pathological conditions has led to the development of a host of chemically diverse small molecule GSK-3 inhibitors, such as BIP-135. GSK-3 inhibition ...