Browsing by Keyword "Ion Channels"

Now showing items 1-7 of 7

    • Angiotensin II Induced Cardiac Dysfunction on a Chip 

      Horton, Renita E.; Yadid, Moran; McCain, Megan L.; Sheehy, Sean P.; Pasqualini, Francesco S.; Park, Sung-Jin; Cho, Alexander; Campbell, Patrick; Parker, Kevin Kit (Public Library of Science, 2016)
      In vitro disease models offer the ability to study specific systemic features in isolation to better understand underlying mechanisms that lead to dysfunction. Here, we present a cardiac dysfunction model using angiotensin ...

    • Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice 

      Wu, Xudong; Indzhykulian, Artur A.; Niksch, Paul D.; Webber, Roxanna M.; Garcia-Gonzalez, Miguel; Watnick, Terry; Zhou, Jing; Vollrath, Melissa A.; Corey, David P. (Public Library of Science, 2016)
      Members of the TRP superfamily of ion channels mediate mechanosensation in some organisms, and have been suggested as candidates for the mechanotransduction channel in vertebrate hair cells. Some TRP channels can be ruled ...

    • MICU2, a Paralog of MICU1, Resides within the Mitochondrial Uniporter Complex to Regulate Calcium Handling 

      Plovanich, Molly Elizabeth; Bogorad, Roman L.; Sancak, Yasemin; Kamer, Kimberli Jean; Strittmatter, Laura Anne; Li, Andrew Amos; Girgis, Hany S.; Kuchimanchi, Satya; De Groot, Jack; Speciner, Lauren; Taneja, Nathan; OShea, Jonathan; Koteliansky, Victor; Mootha, Vamsi Krishna (Public Library of Science, 2013)
      Mitochondrial calcium uptake is present in nearly all vertebrate tissues and is believed to be critical in shaping calcium signaling, regulating ATP synthesis and controlling cell death. Calcium uptake occurs through a ...

    • Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling 

      Wen, Ya; Alshikho, Mohamad J.; Herbert, Martha R. (Public Library of Science, 2016)
      We used established databases in standard ways to systematically characterize gene ontologies, pathways and functional linkages in the large set of genes now associated with autism spectrum disorders (ASDs). These conditions ...

    • Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters 

      Munro, Thomas A.; Huang, Xi-Ping; Inglese, Carmela; Perrone, Maria Grazia; Van't Veer, Ashlee; Carroll, F. Ivy; Béguin, Cécile; Carlezon, William A.; Colabufo, Nicola A.; Cohen, Bruce M.; Roth, Bryan L. (Public Library of Science, 2013)
      Background: Nor-BNI, GNTI and JDTic induce selective κ opioid antagonism that is delayed and extremely prolonged, but some other effects are of rapid onset and brief duration. The transient effects of these compounds differ, ...

    • Sperm BerserKers 

      Clapham, David E (eLife Sciences Publications, Ltd, 2013)
      Human sperm cells rely on an unusual type of potassium ion channel.

    • Structural Interaction and Functional Regulation of Polycystin-2 by Filamin 

      Dai, Xiao-Qing; Li, Qiang; Wang, Zuocheng; Cantero, María del Rocío; Tu, Jian-Cheng; Chen, Xing-Zhen; Wang, Qian; Li, Shu; Shen, Ji; Cantiello, Horacio Fabio (Public Library of Science, 2012)
      Filamins are important actin cross-linking proteins implicated in scaffolding, membrane stabilization and signal transduction, through interaction with ion channels, receptors and signaling proteins. Here we report the ...