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    • The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl− co-transporters 

      delos Heros, Paola; Alessi, Dario R.; Gourlay, Robert; Campbell, David G.; Deak, Maria; Macartney, Thomas J.; Kahle, Kristopher T.; Zhang, Jinwei (Portland Press Ltd., 2014)
      Precise homoeostasis of the intracellular concentration of Cl− is achieved via the co-ordinated activities of the Cl− influx and efflux. We demonstrate that the WNK (WNK lysine-deficient protein kinase)-activated SPAK ...