Now showing items 1-5 of 5

    • Effect of substrate stiffness on early human embryonic stem cell differentiation 

      Eroshenko, Nikolai Alexandrovich; Ramachandran, Rukmani; Yadavalli, Vamsi K; Rao, Rajesh Raghavendran (BioMed Central, 2013)
      Background: The pluripotency and self renewing properties of human embryonic stem cells (hESC) make them a valuable tool in the fields of developmental biology, pharmacology and regenerative medicine. Therefore, there ...
    • Engraftment of enteric neural progenitor cells into the injured adult brain 

      Belkind-Gerson, Jaime; Hotta, Ryo; Whalen, Michael; Nayyar, Naema; Nagy, Nandor; Cheng, Lily; Zuckerman, Aaron; Goldstein, Allan M.; Dietrich, Jorg (BioMed Central, 2016)
      Background: A major area of unmet need is the development of strategies to restore neuronal network systems and to recover brain function in patients with neurological disease. The use of cell-based therapies remains an ...
    • Pharmacokinetics of Natural and Engineered Secreted Factors Delivered by Mesenchymal Stromal Cells 

      Elman, Jessica S.; Murray, Ryan M.; Wang, Fangjing; Shen, Keyue; Gao, Shan; Conway, Kevin E.; Yarmush, Martin L.; Tannous, Bakhos A.; Weissleder, Ralph; Parekkadan, Biju (Public Library of Science, 2014)
      Transient cell therapy is an emerging drug class that requires new approaches for pharmacological monitoring during use. Human mesenchymal stem cells (MSCs) are a clinically-tested transient cell therapeutic that naturally ...
    • The Development and Application of a Human Stem Cell-Based Model of Chemotherapy-Induced Neuropathy 

      Snavely, Andrew Richard (2018-09-13)
      Chemotherapy-induced peripheral neuropathy (CIPN) is a devastating side effect of multiple classes of antineoplastic drugs used to treat cancer. These agents cause degeneration of the peripheral axons of sensory, motor and ...
    • Zfp322a Regulates Mouse ES Cell Pluripotency and Enhances Reprogramming Efficiency 

      Ma, Hui; Ng, Hui Min; Teh, Xiuwen; Li, Hu; Lee, Yun Hwa; Chong, Yew Mei; Loh, Yuin Han; Collins, James J.; Feng, Bo; Yang, Henry; Wu, Qiang (Public Library of Science, 2014)
      Embryonic stem (ES) cells derived from the inner cell mass (ICM) of blastocysts are characterised by their ability to self-renew and their potential to differentiate into many different cell types. Recent studies have shown ...