Now showing items 1-8 of 8

    • Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice 

      Sun, Jiusong; Sukhova, Galina K.; Zhang, Jie; Chen, Han; Sjoberg, Sara; Libby, Peter; Xia, Mingcan; Xiong, Na; Gelb, Bruce D.; Shi, Guo-Ping (Ovid Technologies (Wolters Kluwer Health), 2011)
      Objective: Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression of CatK in human abdominal aortic aneurysm (AAA) lesions. Whether this protease participates directly ...
    • Different Roles of Mast Cells in Obesity and Diabetes: Lessons from Experimental Animals and Humans 

      Shi, Michael A.; Shi, Guo-Ping (Frontiers Research Foundation, 2012)
      Mast cells (MCs) play an important role in allergic hyperresponsiveness and in defending microorganism infections. Recent studies of experimental animals and humans have suggested that MCs participate in obesity and diabetes. ...
    • Discovering cancer immunotherapy targets in vivo 

      Zhou, Penghui; Wucherpfennig, Kai W (Landes Bioscience, 2014)
      A key challenge facing the cancer immunology field is the discovery of the most suitable targets for therapeutic intervention. We recently reported a novel RNA-interference (RNAi)-based approach for systematic discovery ...
    • Impact of MAPK Pathway Activation in BRAFV600 Melanoma on T Cell and Dendritic Cell Function 

      Ott, Patrick A.; Bhardwaj, Nina (Frontiers Media S.A., 2013)
      Constitutive upregulation of the MAPK pathway by a BRAFV600 mutation occurs in about half of melanomas. This leads to increased oncogenic properties such as tumor cell invasion, metastatic potential, and resistance to ...
    • Optimizing the Efficacy of Adoptive T Cell Transfers and CAR-T Therapies 

      Liu, Yutong (2023-05-02)
      Adoptive T cell therapy (ACT), including chimeric antigen receptor (CAR) T cell therapy, is a type of immunotherapy that typically uses a patient’s own T cells to treat tumors. While ACT has demonstrated tremendous success ...
    • T Cell Help Shapes B Cell Tolerance 

      Akama-Garren, Elliot (2023-11-21)
      Maintenance of B cell tolerance allows organisms to defend against pathogens without attacking their own tissues. Loss of B cell tolerance leads to autoimmune disease driven by the accumulation of pathogenic autoantibodies. ...
    • The Fourth Intracellular Src Homology 3 Binding Motif of CD2 is Required for Durable T Cell Activity 

      Corcoran, Erik Martin (2023-04-21)
      Recent research from both the bench and clinic have demonstrated the importance of the CD2/CD58 axis in the effectiveness of T cells in diseases where chronic antigen exposure is common. Despite this understanding, the ...
    • Thymic Mechanisms of T Cell Tolerance 

      Michelson, Daniel Ahn (2023-06-01)
      Peripheral-tissue antigen (PTA) expression by medullary thymic epithelial cells (mTECs) eliminates self-reactive T cells from the immune repertoire, protecting against autoimmunity. The transcription factor (TF) Aire plays ...