Browsing by Keyword "T cell exhaustion"

Now showing items 1-3 of 3

Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model

Suarez, Eloah Rabello; Chang, De-Kuan; Sun, Jiusong; Sui, Jianhua; Freeman, Gordon J.; Signoretti, Sabina; Zhu, Quan; Marasco, Wayne A. (Impact Journals LLC, 2016)

Advances in the treatment of metastatic clear cell renal cell carcinoma (ccRCC) have led to improved progression-free survival of many patients; however the therapies are toxic, rarely achieve durable long-term complete ...
The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation

Bardhan, Kankana; Anagnostou, Theodora; Boussiotis, Vassiliki A. (Frontiers Media S.A., 2016)

The immune system maintains a critically organized network to defend against foreign particles, while evading self-reactivity simultaneously. T lymphocytes function as effectors and play an important regulatory role to ...
Understanding anti-leukemia responses to donor lymphocyte infusion

Bachireddy, Pavan; Wu, Catherine J (Landes Bioscience, 2014)

Donor lymphocyte infusion (DLI) is an established and potentially curative immune therapy for relapsed leukemia after hematopoietic stem cell transplant (HSCT). Herein, we describe the utility of DLI as a tractable model ...