Browsing by Keyword "Transgenic Animals"

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    • Evaluation of OPEN Zinc Finger Nucleases for Direct Gene Targeting of the ROSA26 Locus in Mouse Embryos 

      Hermann, Mario; Rector, Kyle; Ruiz, Joseph; Becher, Burkhard; Bürki, Kurt; Khayter, Cyd; Aguzzi, Adriano; Buch, Thorsten; Pelczar, Pawel; Maeder, Morgan L.; Joung, Jae Keith (Public Library of Science, 2012)
      Zinc finger nucleases (ZFNs) enable precise genome modification in a variety of organisms and cell types. Commercial ZFNs were reported to enhance gene targeting directly in mouse zygotes, whereas similar approaches using ...

    • Interleukin-33 Primes Mast Cells for Activation by IgG Immune Complexes 

      Kaieda, Shinjiro; Wang, Jun-Xia; Shnayder, Ruslan; Fishgal, Nadia; Hei, Hillary; Lee, Richard Theodore; Stevens, Richard Leslie; Nigrovic, Peter Andrija (Public Library of Science, 2012)
      Mast cells (MCs) are heterogeneous cells whose phenotype is modulated by signals received from the local microenvironment. Recent studies have identified the mesenchymal-derived cytokine IL-33 as a potent direct activator ...