Browsing by Keyword "tumor immunity"

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    • Regulation of T Cell Differentiation and Function by EZH2 

      Karantanos, Theodoros; Chistofides, Anthos; Barhdan, Kankana; Li, Lequn; Boussiotis, Vassiliki A. (Frontiers Media S.A., 2016)
      The enhancer of zeste homolog 2 (EZH2), one of the polycomb-group proteins, is the catalytic subunit of Polycomb-repressive complex 2 (PRC2) and induces the trimethylation of the histone H3 lysine 27 (H3K27me3) promoting ...

    • The Role of Heat Shock Proteins in Antigen Cross Presentation 

      Murshid, Ayesha; Gong, Jianlin; Calderwood, Stuart K. (Frontiers Research Foundation, 2012)
      Heat shock proteins (HSPs) are molecular chaperones that bind tumor antigens and mediate their uptake into antigen presenting cells. HSP–antigen complexes are then directed toward either the MHC class I pathway through ...