Now showing items 1-2 of 2

    • Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer 

      Schietinger, Andrea; Arina, Ainhoa; Liu, Rebecca B; Wells, Sam; Huang, Jianhua; Engels, Boris; Bindokas, Vytas; Bartkowiak, Todd; Lee, David; Herrmann, Andreas; Piston, David W; Pittet, Mikael J; Lin, P Charles; Zal, Tomasz; Schreiber, Hans (Landes Bioscience, 2013)
      A fluorescence-based, high-resolution imaging approach was used to visualize longitudinally the cellular events unfolding during T cell-mediated tumor destruction. The dynamic interplay of T cells, cancer cells, cancer ...
    • The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment 

      Sharma, Madhav D.; Shinde, Rahul; McGaha, Tracy L.; Huang, Lei; Holmgaard, Rikke B.; Wolchok, Jedd D.; Mautino, Mario R.; Celis, Esteban; Sharpe, Arlene H.; Francisco, Loise M.; Powell, Jonathan D.; Yagita, Hideo; Mellor, Andrew L.; Blazar, Bruce R.; Munn, David H. (American Association for the Advancement of Science, 2015)
      The tumor microenvironment is profoundly immunosuppressive. We show that multiple tumor types create intratumoral immune suppression driven by a specialized form of regulatory T cell (Treg) activation dependent on the PTEN ...