Browsing by Keyword "tumor immunology"
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Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer
(Landes Bioscience, 2013)A fluorescence-based, high-resolution imaging approach was used to visualize longitudinally the cellular events unfolding during T cell-mediated tumor destruction. The dynamic interplay of T cells, cancer cells, cancer ... -
The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment
(American Association for the Advancement of Science, 2015)The tumor microenvironment is profoundly immunosuppressive. We show that multiple tumor types create intratumoral immune suppression driven by a specialized form of regulatory T cell (Treg) activation dependent on the PTEN ...