Browsing by Keyword "tumour"

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    • Pml Represses Tumour Progression Through Inhibition of mTOR 

      Bernardi, Rosa; Papa, Antonella; Egia, Ainara; Coltella, Nadia; Teruya-Feldstein, Julie; Signoretti, Sabina; Pandolfi, Pier Paolo (Wiley-VCH Verlag Berlin, 2011)
      The promyelocytic leukaemia gene PML is a pleiotropic tumour suppressor. We have recently demonstrated that PML opposes \(mTOR-HIF1\alpha -VEGF\) signalling in hypoxia. To determine the relevance of PML-mTOR antagonism in ...