Browsing by Keyword "upregulation"

Now showing items 1-1 of 1

    • Downregulation of cyclin D1 sensitizes cancer cells to MDM2 antagonist Nutlin-3 

      Yang, Peipei; Chen, Weicai; Li, Xuhui; Eilers, Grant; He, Quan; Liu, Lili; Wu, Yeqing; Wu, Yuehong; Yu, Wei; Fletcher, Jonathan A.; Ou, Wen-Bin (Impact Journals LLC, 2016)
      The MDM2-p53 pathway has a prominent oncogenic function in the pathogenesis of various cancers. Nutlin-3, a small-molecule antagonist of MDM2-p53 interaction, inhibits proliferation in cancer cells with wild-type p53. ...