Person: Church, Alanna
Email Address
AA Acceptance Date
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
First Name
Name
Search Results
Publication Characterization of a novel fusion gene EML4-NTRK3 in a case of recurrent congenital fibrosarcoma
(Cold Spring Harbor Laboratory Press, 2015) Tannenbaum-Dvir, Sarah; Glade Bender, Julia L.; Church, Alanna; Janeway, Katherine; Harris, Marian; Mansukhani, Mahesh M.; Nagy, Peter L.; Andrews, Stuart J.; Murty, Vundavalli V.; Kadenhe-Chiweshe, Angela; Connolly, Eileen P.; Kung, Andrew L.; Dela Cruz, Filemon S.Abstract We describe the clinical course of a recurrent case of congenital fibrosarcoma diagnosed in a 9-mo-old boy with a history of hemimelia. Following complete surgical resection of the primary tumor, the patient subsequently presented with bulky bilateral pulmonary metastases 6 mo following surgery. Molecular characterization of the tumor revealed the absence of the prototypical ETV6-NTRK3 translocation. However, tumor characterization incorporating cytogenetic, array comparative genomic hybridization, and RNA sequencing analyses, revealed a somatic t(2;15)(2p21;15q25) translocation resulting in the novel fusion of EML4 with NTRK3. Cloning and expression of EML4-NTRK3 in murine fibroblast NIH 3T3 cells revealed a potent tumorigenic phenotype as assessed in vitro and in vivo. These results demonstrate that multiple fusion partners targeting NTRK3 can contribute to the development of congenital fibrosarcoma.
Publication Recurrent EML4–NTRK3 fusions in infantile fibrosarcoma and congenital mesoblastic nephroma suggest a revised testing strategy
(Springer Science and Business Media LLC, 2017-11-03) Church, Alanna; Calicchio, Monica; Nardi, Valentina; Skálová, Alena; Pinto, Andre; Dillon, Deborah; Gomez-Fernandez, Carmen; Manoj, Namitha; Haimes, Josh; Stahl, Joshua; Dela Cruz, Filemon; Tannenbaum-Dvir, Sarah; Glade-Bender, Julia; Kung, Andrew; DuBois, Steven; Kozakewich, Harry; Janeway, Katherine; Perez-Atayde, Antonio; Harris, Marian