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Liu, Sophia

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Liu

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Sophia

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Liu, Sophia
Author's Publications: search.filters.isAuthorOfPublication.e24e6c8d-2141-4679-9fff-a5cf4cc5fdd6

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    Efficient, Continuous Mutagenesis in Human Cells Using a Pseudo-Random DNA Editor
    (Springer Science and Business Media LLC, 2019-12-16) Chen, Haiqi; Liu, Sophia; Padula, Samuel; Lesman, Daniel; Griswold, Kettner; Lin, Allen; Zhao, Tongtong; Marshall, Jamie; Chen, Fei
    Here, we describe TRACE, a method that enables continuous, targeted mutagenesis in human cells using a cytidine deaminase fused to T7 RNA polymerase. TRACE induces high rates of mutagenesis over multiple cell generations in genes under the control of a T7 promoter integrated in the genome. Using TRACE in a MEK1 inhibitor resistance screen, we identified functionally correlated mutations.
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    RNA Timestamps Identify the Age of Single Molecules in RNA Sequencing
    (Springer Science and Business Media LLC, 2020-10-19) Rodriques, Samuel; Chen, Linlin; Liu, Sophia; Zhong, Ellen D.; Scherrer, Joseph R.; Boyden, Edward S.; Chen, Fei