Publication: Expanding protein universe and its origin from the biological Big Bang
Loading...
Open/View Files
Date
2002
Published Version
Journal Title
Journal ISSN
Volume Title
Publisher
National Academy of Sciences
The Harvard community has made this article openly available. Please share how this access benefits you.
Citation
Dokholyan, N. V., B. Shakhnovich, and E. I. Shakhnovich. 2002. “Expanding Protein Universe and Its Origin from the Biological Big Bang.” Proceedings of the National Academy of Sciences99 (22): 14132–36. https://doi.org/10.1073/pnas.202497999.
Abstract
The bottom-up approach to understanding the evolution of organisms is by studying molecular evolution. With the large number of protein structures identified in the past decades, we have discovered peculiar patterns that nature imprints on protein structural space in the course of evolution. In particular, we have discovered that the universe of protein structures is organized hierarchically into a scale-free network. By understanding the cause of these patterns, we attempt to glance at the very origin of life.
Description
Other Available Sources
Research Data
Keywords
Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material (LAA), as set forth at Terms of Service