Publication: The 8q24 Cancer Risk Variant Rs6983267 Shows Long-Range Interaction With MYC in Colorectal Cancer
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Date
2009-06-28
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Springer Science and Business Media LLC
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Pomerantz, Mark, Nasim Ahmadiyeh, Li Jia, Paula Herman, Michael Verzi, Harshavardhan Doddapaneni, Christine A. Beckwith et al. "The 8q24 Cancer Risk Variant Rs6983267 Shows Long-Range Interaction With MYC in Colorectal Cancer." Nature Genetics 41, no. 8 (2009): 882-884. DOI: 10.1038/ng.403
Abstract
An inherited variant on chromosome 8q24, rs6983267, is significantly associated with cancer pathogenesis. We present evidence that this region is a transcriptional enhancer, that the risk region physically interacts with the MYC proto-oncogene, and that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2). These data provide strong support for a biological mechanism underlying this non-protein coding risk variant.
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Genetics
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