Browsing Faculty of Arts and Sciences by Author "Ma, Enbo"
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High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
Pattanayak, Vikram; Lin, Steven; Guilinger, John P.; Ma, Enbo; Doudna, Jennifer A.; Liu, David R. (2013)The RNA-programmable Cas9 endonuclease cleaves double-stranded DNA at sites complementary to a 20-base-pair guide RNA. The Cas9 system has been used to modify genomes in multiple cells and organisms, demonstrating its ...