Browsing Faculty of Arts and Sciences by Title
Now showing items 1036-1055 of 24540
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Antibodies in Vaccine Protection against SIV and HIV-1 Infection
(2012-12-12)The properties of human immunodeficiency virus type 1 (HIV-1) and its simian counterpart SIV that enable persistent replication in the face of robust cellular, antibody, and innate immune responses have complicated efforts ... -
Antibody Responses Against HIV-1 Vaccine Candidates
(2018-09-16)The elicitation of protective antibody responses is likely to be important in developing a successful human immunodeficiency virus type 1 (HIV-1) vaccine. As HIV-1 infection in humans is predominantly transmitted via the ... -
The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine
(eLife Sciences Publications, Ltd, 2016)Phenotypic screens allow the identification of small molecules with promising anticancer activity, but the difficulty in characterizing the mechanism of action of these compounds in human cells often undermines their value ... -
Anticipating One's Troubles: The Costs and Benefits of Negative Expectations
(American Psychological Association, 2009)Although negative expectations may have the benefit of softening the blow when a negative event occurs, they also have the cost of making people feel worse while they are waiting for that event to happen. Three studies ... -
Anticipation of Monetary Reward Can Attenuate the Vigilance Decrement
(Public Library of Science, 2016)Motivation and reward can have differential effects on separate aspects of sustained attention. We previously demonstrated that continuous reward/punishment throughout a sustained attention task improves overall performance, ... -
Anticlimax: The Multilingual Novel at the Turn of the 21st Century
(2021-05-13)I propose to see multilingualism as a mode of critique that offers us new reading strategies and new ways to construct and historicize literary archives. It destabilizes political hegemonies, allowing us to rethink concepts ... -
Anticolonial Public: From Slavery to Independence in Southern Ghana, c. 1500-1957
(2020-10-06)This thesis reveals how human geographies of the Atlantic slave trade shaped the rise and fall of the British colonial state in the Gold Coast (present-day southern Ghana). In 1957, the country of Ghana became the first ... -
Anticorrelated Hard/Soft X-Ray Emission from the X-Ray Burster 4U 0614+091
(American Astronomical Society, 1996)We have detected transient X-ray activity from the X-ray burster 4U 0614+091 simultaneously with BATSE on board the Compton Gamma Ray Observatory (20-100 keV) and the all-sky monitor (ASM) on board the Rossi X-Ray Timing ... -
Antidepressants and Advertising: Psychopharmaceuticals in Crisis
(YJBM, 2012)As the efficacy and science of psychopharmaceuticals has become increasingly uncertain, marketing of these drugs to both physicians and consumers continues to a central part of a multi-billion dollar per year industry in ... -
Antidumping: The Third Rail of Trade Policy
(Council on Foreign Relations, 2005)Although few U.S. politicians will admit it, antidumping policy has strayed far from its original purpose of guarding against predatory foreign firms. It is now little more than an excuse for a few powerful industries to ... -
Antiferromagnetic metal phase in an electron-doped rare-earth nickelate
(Springer Science and Business Media LLC, 2023-01-30)Long viewed as passive elements, antiferromagnetic materials have emerged as promising candidates for spintronic devices due to their insensitivity to external fields and potential for high-speed switching. Recent work ... -
Antiferromagnetic noise correlations in optical lattices
(American Physical Society (APS), 2009)We analyze how noise correlations probed by time-of-flight experiments reveal antiferromagnetic (AF) correlations of fermionic atoms in two-dimensional and three-dimensional optical lattices. Combining analytical and quantum ... -
Antiferromagnetism in Metals: From the Cuprate Superconductors to the Heavy Fermion Materials
(IOP Publishing, 2012)The critical theory of the onset of antiferromagnetism in metals, with concomitant Fermi surface reconstruction, has recently been shown to be strongly coupled in two spatial dimensions. The onset of unconventional ... -
Antifungal Chemical Compounds Identified Using a C. elegans Pathogenicity Assay
(Public Library of Science, 2007)There is an urgent need for the development of new antifungal agents. A facile in vivo model that evaluates libraries of chemical compounds could solve some of the main obstacles in current antifungal discovery. We show ... -
Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2
(National Academy of Sciences, 2001) -
Antigen Processing and Presentation: TAPping into ABC Transporters
(Elsevier, 2009)Adaptive, cell-mediated immunity involves the presentation of antigenic peptides on class I MHC molecules at the cell surface. This requires an ABC transporter associated with antigen processing (TAP) to transport antigenic ... -
Antigen-Specific Antibody Glycosylation Is Regulated via Vaccination
(Public Library of Science, 2016)Antibody effector functions, such as antibody-dependent cellular cytotoxicity, complement deposition, and antibody-dependent phagocytosis, play a critical role in immunity against multiple pathogens, particularly in the ... -
Antigen-specific immune modulation using an injectable biomaterial
(2014-06-06)The field of immunology has advanced tremendously over the last 40 years, with seminal findings that have guided the development of powerful new therapies. However, the ability to induce safe and long-lasting antigen-specific ... -
Antigen-specific NK cell memory in rhesus macaques
(2015)Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in murine NK cells. However, it has remained unclear ... -
Antigenic Characterization of the HCMV gH/gL/gO and Pentamer Cell Entry Complexes Reveals Binding Sites for Potently Neutralizing Human Antibodies
(Public Library of Science, 2015)Human Cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant patients and in fetuses following congenital infection. The glycoprotein complexes gH/gL/gO and gH/gL/UL128/UL130/UL131A (Pentamer) are ...