Browsing Faculty of Arts and Sciences by Title
Now showing items 1847-1866 of 24540
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Biochemical characterization of EGFR exon 20 insertion variants and their inhibitor sensitivities
(2023-04-26)Somatic mutations in the epidermal growth factor receptor (EGFR) are a major cause of non-small cell lung cancer (NSCLC). Among these structurally diverse alterations, exon 20 insertions represent a unique subset that ... -
Biochemical Characterization of the Domain Architecture of Chromatin Assembly Motor Proteins Human CHD1 and CHD2
(2015-01-21)The sites where the basic unit of chromatin, the nucleosome, is assembled greatly affects the dynamic compaction/decompaction of eukaryotic genetic material and how the DNA is accessed, read, and interpreted. The nucleosome, ... -
Biochemical reconstitution and characterization of peptidoglycan synthases and glycosidases
(2021-07-12)The peptidoglycan cell wall is a unique macromolecular structure in bacteria that is essential for their survival and morphogenesis. The peptidoglycan synthesis pathway is an excellent target for antibiotics, and decades ... -
Biochemical Studies of TRP Channel Activation and Modulation
(2016-10-19)TRP channels are the cellular sensors behind many elements of somatosensation, including temperature sensing and the perception of pain. In fact, two channels, TRPV1 and TRPA1, expressed in pain-sensing nociceptor neurons, ... -
A Biochemically Active MCM-like Helicase in Bacillus Cereus
(Oxford University Press, 2009)The mini-chromosome maintenance (MCM) proteins serve as the replicative helicases in archaea and eukaryotes. Interestingly, an MCM homolog was identified, by BLAST analysis, within a phage integrated in the bacterium ... -
The Biochemistry and Physiology of Peptidases
(2013-03-14)Peptidases regulate important physiological processes by controlling levels of bioactive peptides and occasionally through noncatalytic processes. This thesis presents a study of prolyl endopeptidase-like (PREPL), which ... -
A Biocompatible Alkene Hydrogenation Merges Organic Synthesis with Microbial Metabolism
(Wiley-Blackwell, 2014)Organic chemists and metabolic engineers use largely orthogonal technologies to construct essential small molecules like pharmaceuticals and commodity chemicals. While chemists have leveraged the unique capabilities of ... -
The Biodiversity Heritage Library: sharing biodiversity with the world
(Sage, 2009)Ten major natural history museum libraries, botanical libraries, and research institutions in the United Kingdom and the United States joined in 2005 to develop a strategy and operational plan to digitize the published ... -
Bioelectric Signaling Regulates Size in Zebrafish Fins
(Public Library of Science, 2014)The scaling relationship between the size of an appendage or organ and that of the body as a whole is tightly regulated during animal development. If a structure grows at a different rate than the rest of the body, this ... -
Bioelectrical Domain Walls in Homogeneous Tissues
(Springer Science and Business Media LLC, 2020-01-20)Electrical signaling in biology is typically associated with action potentials, transient spikes in membrane voltage that return to baseline. Hodgkin-Huxley and related conductance-based models of electrophysiology belong ... -
A bioelectrical phase transition patterns the first vertebrate heartbeats
(Springer Science and Business Media LLC, 2023-09-27)A regular heartbeat is essential to vertebrate life. In the mature heart this function is driven by an anatomically localized pacemaker. In contrast, pacemaking capability is broadly distributed in the early embryonic ... -
Bioelectronics for Cellular Electrophysiology during Tissue Development
(2023-11-21)Gaining insights from high spatiotemporal resolution electrophysiology studies of developmental biosystems, such as developing brains or organoids, is pivotal. These studies play a fundamental role in understanding the ... -
Bioequivalence: The Regulatory Career of a Pharmaceutical Concept
(Johns Hopkins University Press, 2011)Generic drugs cannot be marketed without regulatory and clinical demonstration of "bioequivalence." The authors argue that the concept of "bioequivalence" is a joint regulatory and scientific creation, not purely a technical ... -
Bioethics: Using Its Historical and Social Context
(Little Brown and Company, 2001) -
Biofilm attachment reduction on bioinspired, dynamic, micro-wrinkling surfaces
(IOP Publishing, 2013-09-27)Most bacteria live in multicellular communities known as biofilms that are adherent to surfaces in our environment, from sea beds to plumbing systems. Biofilms are often associated with clinical infections, nosocomial ... -
Biofilm attachment reduction on bioinspired, dynamic, micro-wrinkling surfaces
(IOP Publishing, 2013)Most bacteria live in multicellular communities known as biofilms that are adherent to surfaces in our environment, from sea beds to plumbing systems. Biofilms are often associated with clinical infections, nosocomial ... -
Biogenic Versus Anthropogenic Sources of CO in the United States
(American Geophysical Union, 2008)Aircraft observations of carbon monoxide (CO) from the ICARTT campaign over the eastern United States in summer 2004 (July 1–August 15), interpreted with a global 3-D model of tropospheric chemistry (GEOS-Chem), show that ... -
Biogeochemical drivers of the fate of riverine mercury discharged to the global and Arctic oceans
(Wiley-Blackwell, 2015)Rivers discharge 28 ± 13 Mmol yr1 of mercury (Hg) to ocean margins, an amount comparable to atmospheric deposition to the global oceans. Most of the Hg discharged by rivers is sequestered by burial of benthic sediment in ... -
Biogeography in a Continental Island: Population Structure of the Relict Endemic Centipede Craterostigmus tasmanianus (Chilopoda, Craterostigmomorpha) in Tasmania Using 16S rRNA and COI
(Oxford University Press (OUP), 2011)We used 16S ribosomal RNA (rRNA) and cytochrome c oxidase subunit I (COI) sequence data to investigate the population structure in the centipede Craterostigmus tasmanianus Pocock, 1902 (Chilopoda: Craterostigmomorpha: ... -
Bioinformatic and Mechanistic Studies of Radical Enzymes in Human and Animal Gut Microbiomes
(2023-06-01)The gut microbiomes of animals and humans consist of the trillions of microorganisms co-existing within and outside the host. These niches represent some of the densest microbial communities on Earth, with the microbes ...