Browsing Faculty of Arts and Sciences by Title
Now showing items 5195-5214 of 24540
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Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo
(American Chemical Society (ACS), 2015)The in efficient delivery of proteins into mammalian cells remains a major barrier to realizing the therapeutic potential of many proteins. We and others have previously shown that superpositively charged proteins are ... -
Discovery and Characterization of an Antimicrobial Toxin of the Gut Symbiont Bacteroides fragilis
(2018-08-17)The gut microbiota represents one of most densely populated ecosystems on earth. The trillions of bacteria that populate the gastrointestinal tract carry out essential tasks for the host, such as harvesting energy from ... -
The Discovery and Characterization of Endosomal Escape Enhancing Compounds to Improve Protein Delivery Efficacy
(2015-07-23)The inefficient delivery of proteins into mammalian cells remains a major barrier to realizing the therapeutic potential of many proteins. We and others have previously shown that superpositively charged proteins are ... -
The Discovery and Characterization of NAD-Linked RNA
(2012-09-13)Over the past few decades, RNA has emerged as much more than just an intermediary in biology’s central dogma. RNA is now known to play a variety of catalytic, regulatory and defensive roles in living systems as demonstrated ... -
Discovery and Characterization of Novel Bioactive Peptides and a Natural ERRalpha Ligand
(2013-10-17)Metabolites and peptides have a central role in biology that is often overlooked. Despite the importance of metabolites in key protein-metabolite interactions (PMIs), the extent and identity of these interactions is not ... -
Discovery and Characterization of Novel smORF-Encoded Polypeptides (SEPs)
(2016-01-04)Peptides and small proteins have essential physiological roles including metabolism (insulin), sleep (orexin), and stress (corticotropin-releasing hormone). Recent exploration of the human genome and proteome has revealed ... -
Discovery and Characterization of the Cylindrocyclophane Biosynthetic Pathway
(2016-05-17)Nature constructs structurally diverse, bioactive molecules using enzymes. Many enzymes catalyze synthetically challenging reactions under mild, physiological conditions. Consequently, they have long been a source of ... -
Discovery and characterization of the ligands of NK-cell receptors implicated in human diseases
(2016-08-31)Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that act as first-line defenders against intracellular pathogens. Their functions are dictated by germline-encoded activating and inhibitory ... -
The Discovery and Characterization of the lncRNA Firre
(2015-05-08)RNAs, including long noncoding RNAs (lncRNA), are known to be abundant and important structural components of the nuclear infrastructure. Yet, the identities, functional roles, and localization dynamics of lncRNAs that ... -
Discovery and Development of Novel Deubiquitinase Inhibitors via Parallel High-Throughput Screening
(2022-11-23)Ubiquitination is a critical post-translational modification in cell biology which results in a myriad of functional outcomes including proteasomal degradation of substrate proteins. The regulation of protein homeostasis ... -
Discovery and Functional Interpretation of Genetic Risk in Autoimmune Diseases
(2015-05-08)Autoimmune diseases are chronic and debilitating conditions arising from abnormal immune responses directed against normal body tissues; they collectively affect the lives of 5-10% of the world population. These diseases ... -
Discovery and In Vivo Characterization of Long Noncoding RNAs
(2016-05-17)The noncoding genome, or the portion of the genome that does not encode for proteins, encompasses >95% of the human genome. It has been found that the majority of disease-associated genetic variants identified by genome-wide ... -
Discovery and molecular basis of subtype-selective cyclophilin inhibitors
(Springer Science and Business Media LLC, 2022-09-26)<jats:title>Abstract</jats:title><jats:p>Although cyclophilins are attractive targets for probing biology and therapeutic intervention, no subtype-selective cyclophilin inhibitors have been described. We discovered novel ... -
Discovery of a dynamically unstable actin homolog, Salactin, through advances in Haloarchaeal imaging
(2023-05-15)Archaea are fascinating extremophilic microorganisms that hold great potential for discoveries in cellular biology. Despite progress made in understanding the archaeal domain through metagenomic, biochemical, and structural ... -
Discovery of a Jetlike Structure at the High-Redshift QSO CXOMP J084128.3+131107
(IOP Publishing, 2004)The Chandra Multiwavelength Project has discovered a jetlike structure associated with a newly recognized QSO at redshift z = 1.866. The system was 9farcm4 off-axis during an observation of 3C 207. Although significantly ... -
Discovery of a mRNA Mitochondrial Localization Element in Saccharomyces Cerevisiae by Nonhomologous Random Recombination and In Vivo Selection
(Oxford University Press, 2007)In budding yeast, over 100 nuclear-encoded mRNAs are localized to the mitochondria. The determinants of mRNA localization to the mitochondria are not well understood, and protein factors involved in this process have not ... -
Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation
(John Wiley and Sons Inc., 2015)A scalable and cost‐effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This ... -
Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor
(American Chemical Society, 2013)The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion. Here we report the discovery ... -
Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma
(American Chemical Society, 2014)BTK is a member of the TEC family of non-receptor tyrosine kinases whose deregulation has been implicated in a variety of B-cell-related diseases. We have used structure-based drug design in conjunction with kinome profiling ... -
Discovery of a Second Transient Low-mass X-ray Binary in the Globular Cluster Ngc 6440
(American Astronomical Society, 2010)We have discovered a new transient low-mass X-ray binary, NGC 6440 X-2, with Chandra/ACIS, RXTE/PCA, and Swift/XRT observations of the globular cluster NGC 6440. The discovery outburst (2009 July 28-31) peaked at L-X similar ...