Browsing Faculty of Arts and Sciences by Title

Now showing items 5225-5244 of 24524

    • Discovery of cancer vulnerabilities in gene expression regulation pathway 

      Zhou, Chen (2023-12-11)
      Cancer is one of the leading causes of death and many researchers are working on combating cancer. Despite significant progress in cancer therapeutics, many cancers still lack targeted therapies and new ways to enhance the ...

    • Discovery of Candidate H2O Disk Masers in Active Galactic Nuclei and Estimations of Centripetal Accelerations 

      Greenhill, Lincoln Jared; Kondratko, Paul T.; Moran, James M.; Tilak, Avanti (IOP Publishing, 2009)
      Based on spectroscopic signatures, about one-third of known H2O maser sources in active galactic nuclei (AGNs) are believed to arise in highly inclined accretion disks around central engines. These “disk maser candidates” ...

    • Discovery of Collimated Bipolar Outflows in the Planetary Nebula TH 2-A 

      Danehkar, Ashkbiz (IOP Publishing, 2015)
      We present a comprehensive set of spatially resolved, integral field spectroscopic mapping of the Wolf-Rayet planetary nebula Th 2-A, obtained using the Wide Field Spectrograph on the Australian National University 2.3-m ...

    • Discovery of eight z~ 6 quasars from Pan-STARRS1 

      Bañados, E.; Venemans, B. P.; Morganson, E.; Decarli, R.; Walter, F.; Chambers, K. C.; Rix, H.-W.; Farina, E. P.; Fan, X.; Jiang, L.; McGreer, I.; De Rosa, G.; Simcoe, R.; Weiß, A.; Price, P. A.; Morgan, J. S.; Burgett, W. S.; Greiner, J.; Kaiser, N.; Kudritzki, R.-P.; Magnier, E. A.; Metcalfe, N.; Stubbs, Christopher William; Sweeney, W.; Tonry, J. L.; Wainscoat, R. J.; Waters, C. (IOP Publishing, 2014)
      High-redshift quasars are currently the only probes of the growth of supermassive black holes and potential tracers of structure evolution at early cosmic time. Here we present our candidate selection criteria from the ...

    • Discovery of Giant Gamma-ray Bubbles in the Milky Way 

      Su, Meng (2012-08-09)
      Based on data from the Fermi Gamma-ray Space Telescope, we have discovered two gigantic gamma-ray emitting bubble structures in our Milky Way (known as the Fermi bubbles), extending \(\sim 50\) degrees above and below the ...

    • The Discovery of H2O Maser Emission in Seven AGN and at High Velocities in the Circinus Galaxy 

      Greenhill, Lincoln Jared; Kondratko, P. T.; Lovell, J. E. J.; Kuiper, T. B. H.; Moran, James M.; Jauncey, D. L.; Baines, G. P. (IOP Publishing, 2002)
      We report the discovery of H2O maser emission at 1.35 cm wavelength in seven active galactic nuclei (at distances up to < 80 Mpc) during a survey conducted at the 70-m diameter antenna of the NASA Deep Space Network near ...

    • Discovery of highly selective inhibitors to probe the physiology of the bacterial cell envelope 

      Muscato, Jacob (2022-05-11)
      Traditional high-throughput screening approaches have failed to efficiently discover specific, biologically active inhibitors for use as probes and development into therapeutics. New strategies are therefore required to ...

    • Discovery of Human sORF-Encoded Polypeptides (SEPs) in Cell Lines and Tissue 

      Ma, Jiao; Ward, Carl C.; Jungreis, Irwin; Slavoff, Sarah A.; Schwaid, Adam G.; Neveu, John; Budnik, Bogdan A.; Kellis, Manolis; Saghatelian, Alan (American Chemical Society, 2014)
      The existence of nonannotated protein-coding human short open reading frames (sORFs) has been revealed through the direct detection of their sORF-encoded polypeptide (SEP) products. The discovery of novel SEPs increases ...

    • Discovery of near-ultraviolet counterparts to millisecond pulsars in the globular cluster 47 Tucanae 

      Rivera-Sandoval, L. E.; van den Berg, Maureen C.; Heinke, C. O.; Cohn, H. N.; Lugger, P. M.; Freire, P.; Anderson, J.; Serenelli, A. M.; Althaus, L. G.; Cool, A. M.; Grindlay, Jonathan E.; Edmonds, P. D.; Wijnands, R.; Ivanova, N. (Oxford University Press (OUP), 2015)
      We report the discovery of the likely white dwarf companions to radio millisecond pulsars 47 Tuc Q and 47 Tuc S in the globular cluster 47 Tucanae. These blue stars were found in near-ultraviolet images from the Hubble ...

    • Discovery of Novel Lipid Pathways associated with the Metabolic Syndrome 

      Homan, Edwin (2013-02-19)
      The prevalence of obesity and type 2 diabetes has increased at alarming rates in recent decades. These diseases are prominent components of the metabolic syndrome, which is characterized by marked dyslipidemia. Adipose ...

    • Discovery of Novel Molecular Glues and Targeted Protein Degradation Mechanisms for Cancer Therapeutics 

      Li, Yen-Der (2023-05-03)
      Targeted protein degradation has emerged as a promising therapeutic approach that recruits cellular degradation machineries to induce degradation of target proteins. However, the mechanisms underlying many small molecule ...

    • Discovery of Novel Rhabdoviruses in the Blood of Healthy Individuals from West Africa 

      Stremlau, Matthew H.; Andersen, Kristian G.; Folarin, Onikepe A.; Grove, Jessica N.; Odia, Ikponmwonsa; Ehiane, Philomena E.; Omoniwa, Omowunmi; Omoregie, Omigie; Jiang, Pan-Pan; Yozwiak, Nathan L.; Matranga, Christian B.; Yang, Xiao; Gire, Stephen K.; Winnicki, Sarah; Tariyal, Ridhi; Schaffner, Stephen F.; Okokhere, Peter O.; Okogbenin, Sylvanus; Akpede, George O.; Asogun, Danny A.; Agbonlahor, Dennis E.; Walker, Peter J.; Tesh, Robert B.; Levin, Joshua Z.; Garry, Robert F.; Sabeti, Pardis C.; Happi, Christian T. (Public Library of Science, 2015)
      Next-generation sequencing (NGS) has the potential to transform the discovery of viruses causing unexplained acute febrile illness (UAFI) because it does not depend on culturing the pathogen or a priori knowledge of the ...

    • Discovery of Radio Afterglow from the Most Distant Cosmic Explosion 

      Chandra, Poonam; Frail, Dale A.; Fox, Derek; Kulkarni, Shrinivas; Berger, Edo; Cenko, S. Bradley; Bock, Douglas C.-J.; Harrsion, Fiona; Kasliwal, Mansi (IOP Publishing, 2010)
      We report the discovery of radio afterglow emission from the gamma-ray burst GRB 090423, which exploded at a redshift of 8.3, making it the object with the highest known redshift in the Universe. By combining our radio ...

    • Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma 

      Hideshima, Teru; Qi, Jun; Paranal, Ronald; Tang, Weiping; Greenberg, Edward; West, Nathan; Colling, Meaghan; Estiu, Guillermina; Mazitschek, Ralph; Perry, Jennifer; Ohguchi, Hiroto; Cottini, Francesca; Mimura, Naoya; Güllü Görgün; Tai, Yu-Tzu; Richardson, Paul; Carrasco, Ruben; Wiest, Olaf; Schreiber, Stuart; Anderson, Kenneth; Bradner, James (National Academy of Sciences, 2016)
      Multiple myeloma (MM) has proven clinically susceptible to modulation of pathways of protein homeostasis. Blockade of proteasomal degradation of polyubiquitinated misfolded proteins by the proteasome inhibitor bortezomib ...

    • The Discovery of Slowness in Music 

      Rehding, Alexander (Fordham University Press, 2015)

    • Discovery of Small-Molecule Autophagy Modulators in Mammalian Systems 

      Kuo, Szu-Yu (2016-06-07)
      Autophagy is an evolutionarily conserved catabolic process in eukaryotes, which involves the formation of double-membrane vesicles that enclose cellular components and fuse with lysosomes. Autophagy is critical to the ...

    • Discovery of Small-Molecule Enhancers of Reactive Oxygen Species That are Nontoxic or Cause Genotype-Selective Cell Death 

      Adams, Drew J.; Boskovic, Zarko; Theriault, Jimmy R.; Wang, Alex J.; Stern, Andrew M.; Wagner, Bridget K.; Shamji, Alykhan Farid; Schreiber, Stuart L. (American Chemical Society, 2013)
      Elevation of reactive oxygen species (ROS) levels has been observed in many cancer cells relative to nontransformed cells, and recent reports have suggested that small-molecule enhancers of ROS may selectively kill cancer ...

    • Discovery of Small-Molecule Modulators of the Sonic Hedgehog Pathway 

      Schaefer, Giannina I.; Perez, José R.; Duvall, Jeremy R.; Stanton, Benjamin Z.; Shamji, Alykhan F.; Schreiber, Stuart L. (American Chemical Society, 2013)
      The Hedgehog signaling pathway is involved in the development of multicellular organisms and, when deregulated, can contribute to certain cancers, among other diseases. The molecular characterization of the pathway, which ...

    • Discovery of smoking-related biomarkers for advanced treatment in non-small cell lung cancer (NSCLC) 

      Wang , Xinan (2022-03-17)
      Lung cancer is one of the most diagnosed cancers and the leading cause of cancer death globally. Up to 60% of the non-small cell lung cancer lung (NSCLC) cancer patients are diagnosed with distant metastases with a poor ...

    • Discovery of the Very Red Near-Infrared and Optical Afterglow of the Short-Duration Grb 070724a 

      Berger, Edo; Cenko, S. B.; Fox, D. B.; Cucchiara, A. (IOP Publishing, 2009)
      We report the discovery of the near-infrared and optical afterglow of the short-duration gamma-ray burst GRB 070724A. The afterglow is detected in iJHKs observations starting 2.3 hr after the burst with Ks = 19.59± 0.16 ...