Browsing Faculty of Arts and Sciences by Title
Now showing items 5773-5792 of 24506
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The E3 ligase adapter cereblon targets the C-terminal cyclic imide degron
(Springer Science and Business Media LLC, 2022-10-19)The E3 ligase substrate adaptor cereblon (CRBN) is a target of thalidomide and lenalidomide,1 which are therapeutic agents used in the treatment of hematopoietic malignancies2-4 and as ligands for targeted protein ... -
E3 ligase Hei10: a multifaceted structure-based signaling molecule with roles within and beyond meiosis
(Cold Spring Harbor Laboratory Press, 2014)Human enhancer of invasion-10 (Hei10) mediates meiotic recombination and also plays roles in cell proliferation. Here we explore Hei10's roles throughout the sexual cycle of the fungus Sordaria with respect to localization ... -
The Earliest Phases in the Reception of the Homeric Hymns
(Oxford University Press, 2011) -
Early (and Later) LHC Search Strategies for Broad Dimuon Resonances
(Springer Verlag, 2011)Resonance searches generally focus on narrow states that would produce a sharp peak rising over background. Early LHC running will, however, be sensitive primarily to broad resonances. In this paper we demonstrate that ... -
Early and Middle Pleistocene Faunal and Hominins Dispersals through Southwestern Asia
(Elsevier, 2010)This review summarizes the paleoecology of the Early and Middle Pleistocene of southwestern Asia, based on both flora and fauna, retrieved from a series of ‘windows’ provided by the excavated sites. The incomplete ... -
Early Animal Evolution: Emerging Views from Comparative Biology and Geology
(American Association for the Advancement of Science, 1999)The Cambrian appearance of fossils representing diverse phyla has long inspired hypotheses about possible genetic or environmental catalysts of early animal evolution. Only recently, however, have data begun to emerge that ... -
Early Cantos I-XLI
(Cambridge University Press, 1999)Here begins the great unwieldy poem, all light and mud, to which Ezra Pound devoted much of his life. It was the work of a poet too ambitious, too afraid of being cramped, to work according to a plan. Instead of a plan, ... -
An Early Case of Color Symbolism: Ochre Use by Modern Humans in Qafzeh Cave
(University of Chicago Press, 2003)Prehistoric archaeology provides the temporal depth necessary for understanding the evolution of the unique human ability to construct and use complex symbol systems. The longstanding focus on language, a symbol system ... -
Early Cell Fate Determination in Zebrafish
(2013-02-08)ESC/iPSC-derive somatic cells may be ideal for treating disorders caused by cellular deficiency or dysfunction. To form a lineage-specific cell population, ESCs/iPSCs undergo a multi-step process that recapitulates embryonic ... -
Early childhood development in Rwanda: a policy analysis of the human rights legal framework
(BioMed Central, 2016)Background: Early childhood development (ECD) is a critical period that continues to impact human health and productivity throughout the lifetime. Failing to provide policies and programs that support optimal developmental ... -
Early Christian Deathscapes in Fourth-Century Antioch
(2022-06-06)How do religious collectives form? What is sensually attractive about religious practices, objects, and spaces? What feelings are dangerous or desirable, to whom, and to what ends? And how are those feelings formed? “Early ... -
Early Christian Generic Hybridity: The Martyrdom of Pionius and Tragedy
(2020-11-23)Early Christian martyr literature was composed in an ancient Mediterranean world in which a variety of literary and performance genres abounded across porous group boundaries. Noting this cultural vibrancy, a number of ... -
Early Cosmological H ii /He iii Regions and Their Impact on Second‐Generation Star Formation
(American Astronomical Society, 2007)We present the results of three- dimensional radiation hydrodynamics simulations of the formation and evolution of early H II/ He III regions around the first stars. Cooling and recollapse of the gas in the relic H II ... -
Early Developmental Exposure to dsRNA Is Critical for Initiating Efficient Nuclear RNAi in C. elegans
(Elsevier BV, 2017)RNAi has enabled researchers to study the function of many genes. However, it is not understood why some RNAi experiments succeed while others do not. Here, we show in C. elegans that pharyngeal muscle is resistant to RNAi ... -
The Early Evolution of Eukaryotes: A Geological Perspective
(American Association for the Advancement of Science, 1992)Molecular phylogenies of eukaryotic organisms imply patterns of biological and environmental history that can be tested against the geological record. As predicted by sequence comparisons, Precambrian rocks show evidence ... -
Early Formation and Late Merging of the Giant Galaxies
(American Astronomical Society, 2004)The most luminous galaxies in the present universe are found at the centers of the most massive dark matter halos: rich galaxy clusters. In the LambdaCDM cosmology, such massive halo cores are present at redshift z = 6 ... -
Early germ line development in the hemipteran insect Oncopeltus fasciatus
(2022-09-12)The cell lineage that forms eggs and sperm is referred to as the germ line, and the integrity of this cell lineage is critical for the successful reproduction and the survival of a species. The earliest progenitors of the ... -
Early Holocene Openlands in Southern New England
(Ecological Society of America, 2006)The pre-historical vegetation structure in temperate forest regions is much debated among European and North American ecologists and conservationists. Frans Vera’s recent hypothesis that large mammals created mosaics of ... -
Early Life Nutrition Modulates Muscle Stem Cell Number: Implications for Muscle Mass and Repair
(Mary Ann Liebert, 2011)Suboptimal nutrition during prenatal and early postnatal development is associated with increased risk for type 2 diabetes during adult life. A hallmark of such diabetes risk is altered body composition, including reduced ... -
Early Lineage Priming by Trisomy of Erg Leads to Myeloproliferation in a Down Syndrome Model
(Public Library of Science, 2015)Down syndrome (DS), with trisomy of chromosome 21 (HSA21), is the commonest human aneuploidy. Pre-leukemic myeloproliferative changes in DS foetal livers precede the acquisition of GATA1 mutations, transient myeloproliferative ...