Browsing Faculty of Arts and Sciences by Title
Now showing items 6503-6522 of 24540
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Engineered Materials for Improving Cancer Immunotherapy
(2017-01-11)Immunotherapy, the treatment of disease through targeted activation of the immune system, has recently shown unprecedented clinical success for diverse malignancies. In contrast to traditional cancer treatments, which are ... -
Engineered Myosins Drive Filopodial Transport
(Springer Science and Business Media LLC, 2021-02-01)Engineered, light-inducible artificial myosin motors enable selective and direct manipulation of filopodial extensions and provide refined tools to control intracellular cargo transport in vivo. -
Engineered pegRNAs improve prime editing efficiency
(Springer Science and Business Media LLC, 2021-10-04)Prime editing enables the installation of virtually any combination of point mutations, small insertions or small deletions in the DNA of living cells. A prime editing guide RNA (pegRNA) directs the prime editor protein ... -
Engineered potentials and dynamics of ultracold quantum gases under the microscope
(2014-06-06)In this thesis, I present experiments on making and probing strongly correlated gases of ultracold atoms in an optical lattice with engineered potentials and dynamics. The quantum gas microscope first developed in our lab ... -
Engineered proteins that enable site-specific protein and genome modification
(2021-11-16)Dissertation Advisor: David R. Liu Christopher John Podracky Engineered proteins that enable site-specific protein and genome modification Abstract Protein engineering, whether by rational design or ... -
Engineering a Biomimetic Adventitia to Model Fibrosis in a Tissue-Engineered Blood Vessel
(2023-06-30)Cardiovascular disease (CVD) is the global leading cause of death. CVD is commonly caused by fibrosis, or the stiffening of arterial vessel walls. While arterial fibrosis has several pathophysiologies, the outermost vessel ... -
Engineering a Functionalized Biofilm-Based Material for Modulating Escherichia Coli’s Effects in the Mammalian Gastrointestinal Tract
(2015-06-26)This study investigates the potential use of engineered bacterial biofilms as programmable platforms to control bacterial-epithelial interactions in the mammalian gut. It is clear that commensal microflora play a critical ... -
Engineering a proximity-directed O-GlcNAc transferase to control O-GlcNAc signaling
(2021-11-16)O-GlcNAc is a ubiquitous monosaccharide posttranslational modification analogous to phosphorylation found on thousands of nuclear and cytoplasmic proteins involved in every major cellular process. Dysregulation of O-GlcNAc ... -
Engineering acyl carrier protein to enhance production of shortened fatty acids
(BioMed Central, 2016)Background: The acyl carrier protein (ACP) is an essential and ubiquitous component of microbial synthesis of fatty acids, the natural precursor to biofuels. Natural fatty acids usually contain long chains of 16 or more ... -
Engineering and evolution of precision genome editing agents
(2022-06-06)Genome editing agents have had a transformative effect on the study of biological systems, the engineering of cells and organisms with novel properties, and even the treatment of genetic diseases in the clinic. This ... -
Engineering and Identifying Supercharged Proteins for Macromolecule Delivery Into Mammalian Cells
(Elsevier BV, 2012)Supercharged proteins are a class of engineered or naturally occurring proteins with unusually high net positive or negative theoretical charge. Both supernegatively and superpositively charged proteins exhibit a remarkable ... -
Engineering Bacteria for Bio-Based Chemicals Production and Gut Microbiota Applications
(2018-09-16)Microbes have been used for production of food and beverages for thousands of years. In the last century we have begun to modify them by means of genetic engineering to produce more complex compounds and we have gained ... -
Engineering Cardiac Valve Extracellular Matrix Structure and Function for Modeling Pathogenesis and Regeneration
(2017-01-03)Fibrosis of the semilunar cardiac valves clinically manifests as deterioration in late-stage functional performance. Stenotic insufficiencies, due to either congenital or acquired heart valve disease, are a result of ... -
Engineering cooperativity for the control of biomolecular self-assembly
(2023-06-01)How does the complexity of biology reliably emerge from the interactions of individual molecules? This dissertation takes a deeper look at one of the mechanisms involved in ensuring the robustness of biomolecular self-assembly ... -
Engineering CRISPR-Based DNA Transversion Editing Technologies
(2022-01-11)Adenine base editors (ABE) and cytosine base editors (CBE) can efficiently install A-to-G and C-to-T transition edits, respectively. However, until recently, the field lacked base editors to efficiently install C-to-G ... -
Engineering Directed Excitonic Energy Transfer
(American Institute of Physics, 2010)We provide an intuitive platform for engineering exciton transfer dynamics. We show that careful consideration of the spectral density, which describes the system-bath interaction, leads to opportunities to engineer exciton ... -
Engineering E. coli Nissle 1917 to advance and facilitate its use in biomedical applications
(2021-05-06)The concept of engineered living therapeutics refers to the utilization and reprogramming of living cells for a wide range of medical applications. Currently, most examples focus on engineering microbes for use in the human ... -
Engineering Escherichia Coli Fatty Acid Metabolism for the Production of Biofuel Precursors
(2015-05-07)Medium chain fatty acids (MCFAs, 6-12 carbons) are potential precursors to biofuels with properties similar to gasoline and diesel fuel but are not native products of Escherichia coli fatty acid synthesis. Herein we engineer ... -
Engineering Escherichia coli into a Protein Delivery System for Mammalian Cells
(American Chemical Society, 2015)Many Gram-negative pathogens encode type 3 secretion systems, sophisticated nanomachines that deliver proteins directly into the cytoplasm of mammalian cells. These systems present attractive opportunities for therapeutic ... -
Engineering Genetically-Encoded Mineralization and Magnetism via Directed Evolution
(Nature Publishing Group, 2016)Genetically encoding the synthesis of functional nanomaterials such as magnetic nanoparticles enables sensitive and non-invasive biological sensing and control. Via directed evolution of the natural iron-sequestering ...