Browsing Faculty of Arts and Sciences by Title
Now showing items 729-748 of 24540
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Allometric rules for mammalian cortical layer 5 neuron biophysics
(Springer Science and Business Media LLC, 2021-11-10) -
Allosteric Communication in Myosin V: From Small Conformational Changes to Large Directed Movements
(Public Library of Science, 2008)The rigor to post-rigor transition in myosin, a consequence of ATP binding, plays an essential role in the Lymn–Taylor functional cycle because it results in the dissociation of the actomyosin complex after the powerstroke. ... -
Allosteric Integrase Inhibitors Reveal a Role for Integrase During HIV-1 Maturation
(2015-09-20)Integration of the DNA copy of the HIV-1 genome is an essential step for virus replication and is mediated by a homotetrameric complex of the viral protein integrase (IN) in association with the ends of linear viral DNA ... -
Allowing Spontaneity: Practice, Theory, and Ethical Cultivation in Longchenpa's Great Perfection Philosophy of Action
(2018-05-11)This is a study of the philosophy of practical action in the Great Perfection poetry and spiritual exercises of the fourteenth century Tibetan author, Longchen Rabjampa Drime Ozer (klong chen rab 'byams pa dri med 'od zer ... -
ALLPATHS 2: Small Genomes Assembled Accurately and with High Continuity from Short Paired Reads
(BioMed Central, 2009)We demonstrate that genome sequences approaching finished quality can be generated from short paired reads. Using 36 base (fragment) and 26 base (jumping) reads from five microbial genomes of varied GC composition and sizes ... -
Alma Imaging of Hcn, Cs, and Dust in Arp 220 and Ngc 6240
(American Astronomical Society, 2015)We report ALMA Band 7 (350 GHz) imaging at 0".4-0".6 resolution and Band 9 (696 GHz) at similar to 0".25 resolution of the luminous IR galaxies Arp 220 and NGC 6240. The long wavelength dust continuum is used to estimate ... -
ALMA Observations of the Host Galaxy of GRB 090423 at Z = 8.23: Deep Limits on Obscured Star formation 630 Million Years after the Big Bang.
(IOP Publishing, 2014)We present rest-frame far-infrared (FIR) and optical observations of the host galaxy of GRB 090423 at z = 8.23 from the Atacama Large Millimeter Array (ALMA) and the Spitzer Space Telescope, respectively. The host remains ... -
ALMA Resolves the Nuclear Disks of Arp 220
(American Astronomical Society, 2017)We present 90 mas (37 pc) resolution ALMA imaging of Arp 220 in the CO (1-0) line and continuum at gimel = 2.6 mm. The internal gas distribution and kinematics of both galactic nuclei are well. resolved for the first time. ... -
ALMA reveals a candidate hot and compact disc around the O-type protostar IRAS 16547-4247
(Oxford University Press (OUP), 2015)We present high angular resolution (∼ 0.3′′) submillimeter continuum (0.85 mm) and line observations of the O-type protostar IRAS 16547−4247 carried out with the Atacama Large Millimeter/Submillimeter Array (ALMA). In the ... -
An ALMA Survey of DCN/H13CN and DCO+/H13CO+in Protoplanetary Disks
(American Astronomical Society, 2017-01-31)The deuterium enrichment of molecules is sensitive to their formation environment. Constraining patterns of deuterium chemistry in protoplanetary disks is therefore useful for probing how material is inherited or reprocessed ... -
Almost Optimal Explicit Johnson-Lindenstrauss Families
(Springer Science + Business Media, 2011)The Johnson-Lindenstrauss lemma is a fundamental result in probability with several applications in the design and analysis of algorithms. Constructions of linear embeddings satisfying the Johnson Lindenstrauss property ... -
Almost the Same but Not Quite - the Prosthetic Condition in Latin American Artistic Practices
(2018-09-25)My dissertation studies works of art that simultaneously feature literary and visual components, and that were produced in Latin America after 1980. To approach them, I propose the notion of the prosthetic condition: a way ... -
Alone in the Crowd: The Structure and Spread of Loneliness in a Large Social Network
(American Psychological Association, 2009)The discrepancy between an individual’s loneliness and the number of connections in a social network is well documented, yet little is known about the placement of loneliness within, or the spread of loneliness through, ... -
Alpha-actinin binding kinetics modulate cellular dynamics and force generation
(National Academy of Sciences, 2015) -
Als wär’ es ein Stuck von uns . . . German Politics and Society Traverses Twenty Years of United Germany
(Berghahn Journals, 2010)This essay looks at postunification Germany through the pages of German Politics and Society. The articles published during this period reveal the evolution of intellectuals' understanding of the unified country—concerns ... -
ALS-causative mutations in FUS/TLS confer gain- and loss-of-function by altered association with SMN and U1-snRNP
(2015)The RNA-binding protein FUS/TLS, mutation in which is causative of the fatal motor neuron disease ALS, is demonstrated to directly bind to the U1-snRNP and SMN complexes. ALS-causative mutations in FUS/TLS are shown to ... -
ALS-Implicated Protein TDP-43 Sustains Levels of STMN2, a Mediator of Motor Neuron Growth and Repair
(Springer Nature, 2019-01-14)The discovery that TDP-43 mutations cause familial ALS and that many patients display pathological TDP-43 mislocalization has nominated altered RNA metabolism as a potential disease mechanism. Despite its importance, the ... -
The ALS-Linked Gene TDP-43 Regulates \(IFN\beta\) Expression through a Novel Mechanism of 3' UTR-Mediated Promoter cis-Regulation
(2013-03-20)The TAR DNA-binding protein (TDP-43) is a heterogeneous nuclear ribonucleprotein that is involved in multiple stages of RNA processing. Mutations in the TDP-43 gene and mislocalization of TDP-43 protein have been implicated ... -
Alterations in Energy Metabolism and Neurodegeneration as a Conseqeunce of DNA Damage
(2017-01-18)The correlation between DNA damage and aging has been discussed since Peter Medawar framed the first modern theory of aging in 1952. In support of a causal relationship between DNA damage and aging, most human segmental ...