Browsing Faculty of Arts and Sciences by Title
Now showing items 8686-8705 of 24540
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Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors
(Proceedings of the National Academy of Sciences, 2009)Regenerative efforts typically focus on the delivery of single factors, but it is likely that multiple factors regulating distinct aspects of the regenerative process (e.g., vascularization and stem cell activation) can ... -
Functional Organization of a Neural Network for Aversive Olfactory Learning in Caenorhabditis elegans
(Elsevier, 2010)Many animals use their olfactory systems to learn to avoid dangers, but how neural circuits encode naive and learned olfactory preferences, and switch between those preferences, is poorly understood. Here, we map an olfactory ... -
Functional organization of the circadian timing system
(2014-02-25)The circadian timing system establishes daily rhythms in behavior and physiology throughout the body, ensuring that functions like activity, sleep and hormone release are appropriately timed. Research suggests that his ... -
Functional Query Languages with Categorical Types
(2014-02-25)We study three category-theoretic types in the context of functional query languages (typed lambda-calculi extended with additional operations for bulk data processing). The types we study are: -
Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1
(The Rockefeller University Press, 2014)The leucine zipper, EF hand–containing transmembrane protein 1 (Letm1) gene encodes a mitochondrial inner membrane protein, whose depletion severely perturbs mitochondrial Ca2+ and K+ homeostasis. Here we expressed, purified, ... -
Functional regulation of an arenavirus polymerase complex
(2021-07-12)Emerging RNA viruses present recurring challenges to human, livestock, and plant healthcare efforts worldwide. With compact genomes copied by an inherently error-prone RNA-dependent RNA polymerase (RdRP), RNA viruses are ... -
Functional Relationship between Merlin and the ERM Proteins
(2012-11-15)The ability to spatially restrict specific activities across the cell cortex functionally defines individual cells and tissues. This is achieved, in part, via the assembly of protein complexes that link the plasma membrane ... -
Functional specializations in Drosophila primary mechanosensory neurons: experimental methods, physiology, and models
(2021-11-16)Primary mechanosensors encode the detailed features of mechanical stimuli, with different neurons extracting different stimulus features. How this occurs is not fully understood. This is due partially to the difficulty of ... -
Functional Studies of Candidate Oncogenes in Non-Small Cell Lung Cancer
(2013-10-17)Cancer is a set of complex genetic diseases driven by diverse genomic alterations. The genomic study of cancer has enabled the discovery of novel, targetable events in almost all cancer types and in turn, has led to the ... -
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
(National Academy of Sciences, 2002)Mammalian polo-like kinase (Pik) acts at various stages in early and late mitosis. Pik is phosphorylated and activated in mitosis, and the proper subcellular localization of Pik is essential for mitotic regulation. We have ... -
Functional tuning and network dynamics of touch-sensitive dorsal horn neurons in normal and disease states
(2023-06-01)Tactile signal integration begins in the spinal cord dorsal horn (DH) where axons of primary sensory neurons that innervate the skin and convey discrete streams of sensory information, including innocuous and noxious touch, ... -
Functional, Developmental and Morphological Integration: The Case of the Head and Forelimb in Bipedal Hominins
(John Wiley & Sons, 2008)Integration, a fundamental property of organisms, occurs via multiple mechanisms and for diverse reasons. Although there has been substantial work on the genetic and epigenetic mechanisms by which developmental integration ... -
Functionality through multistability: from deployable structures to soft robots
(2021-12-14)Inflating a rubber balloon leads to a dramatic shape change: a property that is exploited in the design of deployable structures and soft robots. On the one hand, inflation can be used to transform seemingly flat shapes ... -
Functionalizing Aromatic Compounds with Optical Cycling Centers
(Nature, 2022-07-25) -
Functionally Important Interactions between the Nucleotide-Binding Domains of an Antigenic Peptide Transporter
(American Chemical Society, 2008)The transporter associated with antigen processing (TAP), an ABC transporter, pumps cytosolic peptides into the endoplasmic reticulum, where the peptides are loaded onto class I MHC molecules for presentation to the immune ... -
Functioning Water‐insoluble Ferrocenes for Aqueous Organic Flow Battery via Host-Guest Inclusion
(Wiley, 2020-12-09)Ferrocene (Fc) is one of the very limited organic catholyte options for aqueous organic flow batteries (AOFBs), a potential electrochemical energy storage solution to the intermittency of renewable electricity. Commercially ... -
Fundamental Limits to the Electrochemical Impedance Stability of Dielectric Elastomers in Bioelectronics
(American Chemical Society (ACS), 2019-11-28)Incorporation of elastomers into bioelectronics that reduces the mechanical mismatch between electronics and biological systems could potentially improve the long-term electronics–tissue interface. However, the chronic ... -
The Fundamental Properties of Young Stars
(2016-05-18)Accurate knowledge of the fundamental properties of stars--mass, temperature, and luminosity--is key to our understanding of stellar evolution. In particular, empirical measurements of stellar mass are difficult to make ... -
Fundamental Studies of Alcohol Reactions on Gold and Copper
(2017-09-07)The thesis has focused on revealing the mechanistic insights of the gaseous alcohol coupling/dehydrogenation/oxidation reactions for selectively making value-added products on the solid gold/copper single-crystal surfaces ...