Now showing items 8965-8984 of 24465

    • Genetic Variation in the Progesterone Receptor Gene and Ovarian Cancer Risk 

      Terry, Kathryn Lynne; De Vivo, Immaculata; Titus-Ernstoff, L.; Sluss, Patrick M.; Cramer, Daniel William (Oxford University Press (OUP), 2005)
      Evidence suggests a role for progesterone in ovarian cancer development. Progesterone exerts its effect on target cells by interacting with its receptor. Thus, genetic variations that may cause alterations in the biologic ...
    • Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures 

      Lieberman, Tami D.; Flett, Kelly B.; Yelin, Idan; Martin, Thomas R.; McAdam, Alexander J.; Priebe, Gregory P.; Kishony, Roy (2014)
      Advances in sequencing have enabled the identification of mutations acquired by bacterial pathogens during infection1-10. However, it remains unclear whether adaptive mutations fix in the population or lead to pathogen ...
    • Genetic, metabolomic, and lifestyle dynamics in colorectal cancer and chronic disease prevention 

      Bever, Alaina (2024-01-30)
      Abstract Noncommunicable chronic disease is a group of conditions that includes type 2 diabetes, cardiovascular disease, and cancer, and accounts for the majority of total deaths in the United States. Many of these diseases ...
    • Genetically Engineered Transvestites Reveal Novel Mating Genes in Budding Yeast 

      Huberman, Lori Bromer; Murray, Andrew W. (The Genetics Society of America, 2013)
      Haploid budding yeast has two mating types, defined by the alleles of the MAT locus, MATa and MATα. Two haploid cells of opposite mating types mate by signaling to each other using reciprocal pheromones and receptors, ...
    • Genetically Targeted All-Optical Electrophysiology with a Transgenic Cre-Dependent Optopatch Mouse 

      Lou, Shan; Adam, Yoav; Weinstein, Eli Nathan; Williams, E.; Williams, K.; Parot, Vicente Jose; Kavokine, N.; Liberles, Stephen D; Madisen, L.; Zeng, H.; Cohen, Adam Ezra (Society for Neuroscience, 2016)
      Recent advances in optogenetics have enabled simultaneous optical perturbation and optical readout of membrane potential in diverse cell types. Here, we develop and characterize a Cre-dependent transgenic Optopatch2 mouse ...
    • Genetics and Regulation of Bacterial Biofilms 

      Leiman, Sara (2015-03-24)
      Bacterial biofilm formation, the construction of dense, protective, multicellular communities, is a widely conserved behavior. In some bacteria, such as the Gram-positive model organism Bacillus subtilis, the genetics ...
    • Genetics of Antibiotic Synergy in Mycobacterium tuberculosis 

      Tomasi, Francesca Guglielmini (2022-09-09)
      Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb), which has been around for millennia and continues to affect millions of people every year. Successful TB treatment requires ...
    • The Genetics of Life History Traits in the Fungus Neurospora crassa 

      Zimmerman, Kolea (2016-05-13)
      The study of life histories is fundamental to understanding why some organisms live for a very short time while others live for a long time, why some produce thousands of offspring while others produce one, or why some ...
    • Genetics of rheumatoid arthritis contributes to biology and drug discovery 

      Okada, Yukinori; Wu, Di; Trynka, Gosia; Raj, Towfique; Terao, Chikashi; Ikari, Katsunori; Kochi, Yuta; Ohmura, Koichiro; Suzuki, Akari; Yoshida, Shinji; Graham, Robert R.; Manoharan, Arun; Ortmann, Ward; Bhangale, Tushar; Denny, Joshua C.; Carroll, Robert J.; Eyler, Anne E.; Greenberg, Jeffrey D.; Kremer, Joel M.; Pappas, Dimitrios A.; Jiang, Lei; Yin, Jian; Ye, Lingying; Su, Ding-Feng; Yang, Jian; Xie, Gang; Keystone, Ed; Westra, Harm-Jan; Esko, Tõnu; Metspalu, Andres; Zhou, Xuezhong; Gupta, Namrata; Mirel, Daniel; Stahl, Eli A.; Diogo, Dorothée; Cui, Jing; Liao, Katherine; Guo, Michael H.; Myouzen, Keiko; Kawaguchi, Takahisa; Coenen, Marieke J.H.; van Riel, Piet L.C.M.; van de Laar, Mart A.F.J.; Guchelaar, Henk-Jan; Huizinga, Tom W.J.; Dieudé, Philippe; Mariette, Xavier; Bridges, S. Louis; Zhernakova, Alexandra; Toes, Rene E.M.; Tak, Paul P.; Miceli-Richard, Corinne; Bang, So-Young; Lee, Hye-Soon; Martin, Javier; Gonzalez-Gay, Miguel A.; Rodriguez-Rodriguez, Luis; Rantapää-Dahlqvist, Solbritt; Ärlestig, Lisbeth; Choi, Hyon K.; Kamatani, Yoichiro; Galan, Pilar; Lathrop, Mark; Eyre, Steve; Bowes, John; Barton, Anne; de Vries, Niek; Moreland, Larry W.; Criswell, Lindsey A.; Karlson, Elizabeth W.; Taniguchi, Atsuo; Yamada, Ryo; Kubo, Michiaki; Liu, Jun S.; Bae, Sang-Cheol; Worthington, Jane; Padyukov, Leonid; Klareskog, Lars; Gregersen, Peter K.; Raychaudhuri, Soumya; Stranger, Barbara E.; De Jager, Philip L.; Franke, Lude; Visscher, Peter M.; Brown, Matthew A.; Yamanaka, Hisashi; Mimori, Tsuneyo; Takahashi, Atsushi; Xu, Huji; Behrens, Timothy W.; Siminovitch, Katherine A.; Momohara, Shigeki; Matsuda, Fumihiko; Yamamoto, Kazuhiko; Plenge, Robert M. (2013)
      A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated variants with diverse genomic and biological datasets to provide insight into disease pathogenesis and guide drug ...
    • The Genetics of Sexually Selected Male Reproductive Traits in Mice (Mus and Peromyscus Species) 

      Jacobs-Palmer, Emily (2015-05-16)
      Sexual selection is rampant in Nature, and has produced some of the most beautiful and bizarre traits on Earth. Because females are often promiscuous, sexual selection can continue even after mating, as the sperm of multiple ...
    • Genetics, development and evolution of adaptive pigmentation in vertebrates 

      Hoekstra, Hopi E. (Nature Publishing Group, 2006)
      The study of pigmentation has played an important role in the intersection of evolution, genetics, and developmental biology. Pigmentation's utility as a visible phenotypic marker has resulted in over 100 years of intense ...
    • Genetics, Endogenous and Exogenous Exposures, and Human Cancer 

      Liu, Yuxi (2022-06-06)
      Cancer is a complex disease influenced by inherited germline variations and acquired somatic mutations from a variety of endogenous and exogenous exposures. Over the past decades, cancer research has mainly focused on ...
    • GeNets: A unified web platform for network-based analyses of genomic data 

      Li, Taibo; Kim, April; Rosenbluh, Joseph; Horn, Heiko; Greenfeld, Liraz; An, David; Zimmer, Andrew; Liberzon, Arthur; Bistline, Jon; Natoli, Ted; Li, Yang; Tsherniak, Aviad; Narayan, Rajiv; Subramanian, Aravind; Liefeld, Ted; Wong, Bang; Thompson, Dawn; Calvo, Sarah; Carr, Steve; Boehm, Jesse; Jaffe, Jake; Mesirov, Jill; Hacohen, Nir; Regev, Aviv; Lage, Kasper
    • Genitals evolve faster than other traits in Anolis lizards 

      Klaczko, Julia; Ingram, Ty; Losos, Jonathan (Wiley-Blackwell, 2015)
    • Genome Analyses of Single Human Oocytes 

      Hou, Yu; Fan, Wei; Yan, Liying; Li, Rong; Lian, Ying; Huang, Jin; Li, Jinsen; Xu, Liya; Tang, Fuchou; Xie, Xiaoliang Sunney; Qiao, Jie (Elsevier BV, 2013)
      Single-cell genome analyses of human oocytes are important for meiosis research and preimplantation genomic screening. However, the nonuniformity of single-cell whole-genome amplification hindered its use. Here, we demonstrate ...
    • Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii 

      Seim, Inge; Fang, Xiaodong; Xiong, Zhiqiang; Lobanov, Alexey V.; Huang, Zhiyong; Ma, Siming; Feng, Yue; Turanov, Anton A.; Zhu, Yabing; Lenz, Tobias L.; Gerashchenko, Maxim V.; Fan, Dingding; Hee Yim, Sun; Yao, Xiaoming; Jordan, Daniel; Xiong, Yingqi; Ma, Yong; Lyapunov, Andrey N.; Chen, Guanxing; Kulakova, Oksana I.; Sun, Yudong; Lee, Sang-Goo; Bronson, Roderick T.; Moskalev, Alexey A.; Sunyaev, Shamil R.; Zhang, Guojie; Krogh, Anders; Wang, Jun; Gladyshev, Vadim N. (Nature Pub. Group, 2013)
      Bats account for one-fifth of mammalian species, are the only mammals with powered flight, and are among the few animals that echolocate. The insect-eating Brandt’s bat (Myotis brandtii) is the longest-lived bat species ...
    • A Genome Assembly-Integrated Dog 1 Mb BAC Microarray: A Cytogenetic Resource for Canine Cancer Studies and Comparative Genomic Analysis 

      Thomas, R.; Duke, S. E.; Karlsson, Elinor Kathryn; Evans, A.; Ellis, P.; Lindblad-Toh, K.; Langford, C.F.; Breen, M. (Karger, 2008)
      Molecular cytogenetic studies have been instrumental in defining the nature of numerical and structural chromosome changes in human cancers, but their significance remains to be fully understood. The emergence of high ...
    • Genome Engineering Technologies to Change the Genetic Code 

      Lajoie, Marc Joseph (2014-02-25)
      New technologies are making it possible to engineer organisms with fundamentally new and useful properties. In vivo genome engineering technologies capable of manipulating genomes from the nucleotide to the megabase scale ...
    • Genome Engineering Technology and Its Application in Mammalian Cells 

      Cong, Le (2014-06-06)
      The advancement of high-throughput, large-scale biochemical, biophysical, and genetic technologies has enabled the generation of massive amounts of biological data and allowed us to synthesize various types of biomaterial ...