Browsing Faculty of Arts and Sciences by Issue Date
Now showing items 41-60 of 24465
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B-MYB and FOXM1 drive cell division through cooperative regulation of cell cycle genes.
(2024-03-12)Transcription facilitates cell cycle division and progression as it orchestrates the timely expression of genes crucial for each cell cycle phase. Two waves of gene expression prime the cell for replication: the first wave ... -
Multimodal and Context-Aware Computational Pathology
(2024-03-12)Cancers are defined by hallmark histopathological, genomic, and transcriptomic heterogeneity in the tumor and tissue microenvironment that contributes towards variability in treatment response rates and patient outcomes. ... -
Bioinspired Slippery Solutions for Marine Fouling Prevention
(2024-03-12)Recent decades have seen an uptake in the development of non-toxic fouling prevention treatments, especially for marine applications. This trend is driven by technological innovation as a deeper understanding of material ... -
“The hand that played the drum shall also earn dollars.” The Paradox of Dalit Castelessness
(2024-01-31)This dissertation investigates the complex interplay between caste, class, and market-centric discourses in contemporary India, with a particular focus on the experiences of Dalits in corporate workspaces and educational ... -
Quantum simulation and computation with two-dimensional arrays of neutral atoms
(2024-01-31)Programmable quantum systems provide insights into many-body quantum phenomena and enable new methods for computation and metrology. The frontier challenge for these systems is scaling up in the number of quantum particles ... -
Numerical Methods and Analysis Tools for Material Mechanics Across Scales
(2024-01-30)A material's structures at different lengthscales profoundly impact the material's properties and performance. Therefore, it is necessary to investigate material mechanics across scales to develop useful engineering ... -
Genetic, metabolomic, and lifestyle dynamics in colorectal cancer and chronic disease prevention
(2024-01-30)Abstract Noncommunicable chronic disease is a group of conditions that includes type 2 diabetes, cardiovascular disease, and cancer, and accounts for the majority of total deaths in the United States. Many of these diseases ... -
Structuring Incentives in the Development and Use of Artificial Intelligence
(2024-01-30)The success of machine learning (ML) has, in addition to its direct impacts, significantly reshaped the incentives of the humans developing, using, and being targeted by ML systems. This dissertation explores technical ... -
Space for Democracy?: School Governance in the 21st Century
(2024-01-30)The education of young people is a vital task in a democracy with significant implications for both for young people themselves and for the state. How authority over schooling should be shared and organized is, therefore, ... -
Dynamic expression of pleiotropic developmental genes during Drosophila embryogenesis
(2024-01-29)During embryonic development transcription must be precisely regulated over space and time to differentiate tissues and form organs. Organogenesis is directed by a set of pleiotropic transcription factors that are conserved ... -
A New Aminoglycoside Antibiotic Effective Against NpmA-Expressing Escherichia coli
(2024-01-29)Dissertation Advisor: Professor Andrew G. Myers Matthew Peszko A New Aminoglycoside Antibiotic Effective Against NpmA-Expressing Escherichia coli Abstract Aminoglycoside antibiotics (AGAs) are pseudo-oligosaccharide ... -
Assessing Value and Optimizing Decision-Making in Post-Acute Care Across Diverse Populations
(2024-01-29)My dissertation investigates the enhancement of value in post-acute care (PAC) within the U.S. healthcare system, focusing on the largest source of geographic variation in Medicare costs. It combines individual preferences, ... -
Cooking in Space: Food Systems and Technologies for Long-Duration Space Travel
(2024-01-29)The question of how to feed humans in space has persisted since the beginning of space exploration. Tubes of food paste, dehydrated meals, freeze-dried packets, powdered drink pouches: space food has always needed to be ... -
Opening the Democratic Heart: Interest, Charity, and Well-Being in the Political Thought of Alexis de Tocqueville
(2024-01-29)Alexis de Tocqueville’s concept of intérêt bien entendu, as developed in Democracy in America, is among his most notable concepts. However, it is also among his most ambiguous, with interpretations of its meaning ranging ... -
From Dynasty to Nation: A Historiography of the Dueling Portraits of Nguyễn Huệ and Nguyễn Ánh
(2024-01-29)This dissertation is an exercise in historiographical exegesis to explore the dynamics of the evolving reconstruction of the lives and afterlives of Nguyễn Huệ 阮惠 (1753-1792) and Nguyễn Ánh 阮暎 (1762-1820) who dominated the ... -
Early-Stage Non-Conventional Hardware Accelerator Discovery via Optimization Methods and Compiler Analysis
(2024-01-26)In the post-Moore era, where we witness the diminishing returns of traditional transistor scaling, a pivotal transition in accelerator design methodologies has been necessitated to continually enhance power, performance, ... -
AAV-associated toxicity caused by transgene expression in the retinal pigment epithelium
(2024-01-26)The field of AAV gene therapy has recently experienced multiple clinical successes, and AAV continues to be a relatively safe viral vector. Nevertheless, there is a long history of toxic side effects at higher doses, ... -
Clausal Deficiency
(2024-01-25)This thesis investigates the syntactic and semantic properties of clauses which are considered to be deficient in some manner, which are often called infinitival or nonfinite clauses. This thesis is concerned with three ... -
Toward Tonne-Scale NEXT Detectors: SiPM Energy-Tracking Planes and Metalenses for Light Collection
(2024-01-25)The best method of proving the nature of neutrinos is discovering neutrinoless double beta decay (0νββ), as this decay is only possible if the neutrino is Majorana in nature. Measuring the half-life of 0νββ would also ... -
Investigating human disease mechanisms through population genetics and experimental genetic screens
(2024-01-25)In this dissertation, I develop new computational and/or experimental methods to elucidate human disease mechanisms from two different data modalities: (1) genotypes with matched phenotypes and gene expression profiles ...